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CAS 73874-95-0
1,1-Dimethylethyl piperidin-4-ylcarbamate
登记编号：(IV)1055986-1-a,(IV)1055986-1-c、(VIII)1157260-1-a、(VI)1157260-2-a
应用背景（按来源药适应症）
肢端肥大症Paltusotine肠道肿瘤Paltusotine恶性类癌综合征Paltusotine腹泻Paltusotine肝癌Paltusotine回肠肿瘤Paltusotine非小细胞肺癌宗艾替尼肺癌宗艾替尼食道腺癌宗艾替尼食管胃结合部肿瘤宗艾替尼胃癌宗艾替尼转移性乳腺癌宗艾替尼
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| Paltusotine | Tier C · 观察 / 贸易 | - |
| 宗艾替尼Zongertinib | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
6-Bromoquinolin-4-ol→6-Bromo-3-chloroquinolin-4-ol→4,6-Dibromo-3-chloroquinoline→1,1-Dimethylethyl piperidin-4-ylcarbamate→N-Boc-1-(6-bromo-3-chloroquinolin-4-yl)piperidin-4-amine→6-Bromo-4-chloroquinoline→N-Boc-1-(6-bromoquinolin-4-yl)piperidin-4-amine→2-Hydroxy-3-cyano-potassium phenyltrifluoro borate→(3-Cyano-2-hydroxyphenyl)boronic acid→N-Boc-3-[4-(4-aminopiperidin-1-yl)-3-chloroquinolin-6-yl]-2-hydroxybenzonitrile→(3,5-Difluorophenyl)Boranediol→N-Boc-1-(6-(3-cyano-2-hydroxyphenyl)-3-(3,5-difluorophenyl)quinolin-4-yl)piperidin-4-amine→3-[4-(4-Aminopiperidin-1-yl)-3-(3,5-difluorophenyl)quinolin-6-yl]-2-hydroxybenzonitrile dihydrogen chloride→3-[4-(4-Aminopiperidin-1-yl)-3-(3,5-difluorophenyl)quinolin-6-yl]-2-hydroxybenzonitrile→2-Bromo-6-cyanophenol→3-Bromo-2-(methoxymethoxy)benzonitrile
1,1-Dimethylethyl piperidin-4-ylcarbamate→N-Boc-1-(6-bromo-3-chloroquinolin-4-yl)piperidin-4-amine→(3,5-Difluorophenyl)Boranediol→3-[4-(4-Aminopiperidin-1-yl)-3-(3,5-difluorophenyl)quinolin-6-yl]-2-hydroxybenzonitrile→6-Bromo-3,4-dichloroquinoline→2-[(2-Methoxyethoxy)methoxy]-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile→N-Boc-1-(3-chloro-6-[3-cyano-2-(2-methoxy-ethoxymethoxy)-phenyl]-quinolin-4-yl)-piperidin-4-amine→tert-Butyl [1-[3-chloro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinolin-4-yl]piperidin-4-yl]carbamate→3-Bromo-2-[(2-methoxyethoxy)methoxy]benzonitrile→tert-Butyl [1-[6-[3-cyano-2-[(2-methoxyethoxy)methoxy]phenyl]-3-(3,5-difluorophenyl)quinolin-4-yl]piperidin-4-yl]carbamate
1-Fluoro-2-methyl-4-nitrobenzene→1-Methyl-1H-1,3-benzimidazol-5-ol→1-Methyl-5-(2-methyl-4-nitrophenoxy)-1H-1,3-benzimidazole→3-Methyl-4-((1-methyl-1H-benzimidazol-5-yl)oxy)benzenamine→4-Chloro-6-(methylthio)pyrimido[5,4-d]pyrimidine→8-Chloro-2-(methylsulfanyl)pyrimido[5,4-d]pyrimidine hydrogen chloride→N-[3-Methyl-4-[(1-methyl-1H-1,3-benzimidazol-5-yl)oxy]phenyl]-6-(methylsulfanyl)pyrimido[5,4-d]pyrimidin-4-amine→6-(Methanesulfinyl)-N-[3-methyl-4-[(1-methyl-1H-1,3-benzimidazol-5-yl)oxy]phenyl]pyrimido[5,4-d]pyrimidin-4-amine→1,1-Dimethylethyl piperidin-4-ylcarbamate→tert-Butyl [1-(8-[3-methyl-4-[(1-methyl-1H-1,3-benzimidazol-5-yl)oxy]anilino]pyrimido[5,4-d]pyrimidin-2-yl)piperidin-4-yl]carbamate→6-(4-Aminopiperidin-1-yl)-N-[3-methyl-4-[(1-methyl-1H-1,3-benzimidazol-5-yl)oxy]phenyl]pyrimido[5,4-d]pyrimidin-4-amine→2-Propenoyl chloride
6-(Methylsulfanyl)-[1,3]diazino[5,4-d]pyrimidin-4-ol→4-Chloro-6-(methylthio)pyrimido[5,4-d]pyrimidine→3-Methyl-4-((1-methyl-1H-benzimidazol-5-yl)oxy)benzenamine→N-[3-Methyl-4-[(1-methyl-1H-1,3-benzimidazol-5-yl)oxy]phenyl]-6-(methylsulfanyl)pyrimido[5,4-d]pyrimidin-4-amine→N-[3-Methyl-4-[(1-methyl-1H-1,3-benzimidazol-5-yl)oxy]phenyl]-6-(methylsulfanyl)pyrimido[5,4-d]pyrimidin-4-amine hydrogen chloride→6-(Methanesulfonyl)-N-[3-methyl-4-[(1-methyl-1H-1,3-benzimidazol-5-yl)oxy]phenyl]pyrimido[5,4-d]pyrimidin-4-amine→1,1-Dimethylethyl piperidin-4-ylcarbamate→tert-Butyl [1-(8-[3-methyl-4-[(1-methyl-1H-1,3-benzimidazol-5-yl)oxy]anilino]pyrimido[5,4-d]pyrimidin-2-yl)piperidin-4-yl]carbamate→6-(4-Aminopiperidin-1-yl)-N-[3-methyl-4-[(1-methyl-1H-1,3-benzimidazol-5-yl)oxy]phenyl]pyrimido[5,4-d]pyrimidin-4-amine hydrogen chloride (1/3)→(Chloromethyl)acetyl chloride→3-Chloro-N-[1-(8-[3-methyl-4-[(1-methyl-1H-1,3-benzimidazol-5-yl)oxy]anilino]pyrimido[5,4-d]pyrimidin-2-yl)piperidin-4-yl]propanamide
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