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CAS 2172870-89-0
3-[4-(4-Aminopiperidin-1-yl)-3-(3,5-difluorophenyl)quinolin-6-yl]-2-hydroxybenzonitrile
登记编号：(XIV)1055986-1-a,(XIV)1055986-1-c
应用背景（按来源药适应症）
肢端肥大症Paltusotine肠道肿瘤Paltusotine恶性类癌综合征Paltusotine腹泻Paltusotine肝癌Paltusotine回肠肿瘤Paltusotine
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| Paltusotine | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
6-Bromoquinolin-4-ol→6-Bromo-3-chloroquinolin-4-ol→4,6-Dibromo-3-chloroquinoline→1,1-Dimethylethyl piperidin-4-ylcarbamate→N-Boc-1-(6-bromo-3-chloroquinolin-4-yl)piperidin-4-amine→6-Bromo-4-chloroquinoline→N-Boc-1-(6-bromoquinolin-4-yl)piperidin-4-amine→2-Hydroxy-3-cyano-potassium phenyltrifluoro borate→(3-Cyano-2-hydroxyphenyl)boronic acid→N-Boc-3-[4-(4-aminopiperidin-1-yl)-3-chloroquinolin-6-yl]-2-hydroxybenzonitrile→(3,5-Difluorophenyl)Boranediol→N-Boc-1-(6-(3-cyano-2-hydroxyphenyl)-3-(3,5-difluorophenyl)quinolin-4-yl)piperidin-4-amine→3-[4-(4-Aminopiperidin-1-yl)-3-(3,5-difluorophenyl)quinolin-6-yl]-2-hydroxybenzonitrile dihydrogen chloride→3-[4-(4-Aminopiperidin-1-yl)-3-(3,5-difluorophenyl)quinolin-6-yl]-2-hydroxybenzonitrile→2-Bromo-6-cyanophenol→3-Bromo-2-(methoxymethoxy)benzonitrile
1,1-Dimethylethyl piperidin-4-ylcarbamate→N-Boc-1-(6-bromo-3-chloroquinolin-4-yl)piperidin-4-amine→(3,5-Difluorophenyl)Boranediol→3-[4-(4-Aminopiperidin-1-yl)-3-(3,5-difluorophenyl)quinolin-6-yl]-2-hydroxybenzonitrile→6-Bromo-3,4-dichloroquinoline→2-[(2-Methoxyethoxy)methoxy]-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile→N-Boc-1-(3-chloro-6-[3-cyano-2-(2-methoxy-ethoxymethoxy)-phenyl]-quinolin-4-yl)-piperidin-4-amine→tert-Butyl [1-[3-chloro-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)quinolin-4-yl]piperidin-4-yl]carbamate→3-Bromo-2-[(2-methoxyethoxy)methoxy]benzonitrile→tert-Butyl [1-[6-[3-cyano-2-[(2-methoxyethoxy)methoxy]phenyl]-3-(3,5-difluorophenyl)quinolin-4-yl]piperidin-4-yl]carbamate
本站可供应的对应中间体
目录暂未收录该靶点的在售中间体 —— 可直接发起询价，需求会进入撮合池。
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。