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CAS 75885-58-4
(+)-(1S)-2,2-Dimethylcyclopropanecarboxamide2,2-Dimethylcyclopropane-1(S)-carboxamide
登记编号：Cilastatin Sodium-006
应用背景（按来源药适应症）
传染性疾病西司他丁钠
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 西司他丁钠Cilastatin Sodium | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
Ethyl 1,3-dithiane-2-carboxylate→Pentamethylene dibromide→ethyl 2-(5-bromopentyl)-1,3-dithiane-2-carboxylate→Ethyl 7-bromo-2-oxoheptanoate→7-bromo-2-oxoheptanoic acid→(+)-(1S)-2,2-Dimethylcyclopropanecarboxamide→(2Z)-7-Bromo-2-([[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino)hept-2-enoic acid→Plant-derived natural amino-acid L-cysteine
Ethyl 7-chloro-2-oxoheptanoate→(+)-(1S)-2,2-Dimethylcyclopropanecarboxamide→7-Chloro-2-[(1S)-2,2-dimethylcyclopropylcarboxamido]-2-heptenoic acid ethyl ester→7-Chloro-2-[(1S)-2,2-dimethylcyclopropylcarboxamido]-2(Z)-heptenoic acid sodium salt→(R)-Cysteine hydrochloride monohydrate
1-Bromo-5-chloropentane→Ethyl 2-ethoxy-2-oxoacetate→7-Chloro-2-oxoheptanoic acid ethyl ester→Ethyl 7-bromo-2-oxoheptanoate→Butyl 7-chloro-2-oxoheptanoate→2,2-Dimethylcyclopropane-1(S)-carboxamide→7-Chloro-2-[(1S)-2,2-dimethylcyclopropylcarboxamido]-2-heptenoic acid ethyl ester→Ethyl (2Z)-7-bromo-2-([[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino)hept-2-enoate→Butyl (2Z)-7-chloro-2-[[(1S)-2,2-dimethylcyclopropane-1-carbonyl]amino]hept-2-enoate→(2Z)-7-Chloro-2-([[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino)hept-2-enoic acid→(2Z)-7-Bromo-2-([[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino)hept-2-enoic acid→L-Cysteine→(2Z)-7-[[(2R)-2-Amino-2-carboxyethyl]sulfanyl]-2-([[(1S)-2,2-dimethylcyclopropyl]carbonyl]amino)hept-2-enoic acid
Ethyl 7-chloro-2-oxoheptanoate→(+)-(1S)-2,2-Dimethylcyclopropanecarboxamide→7-Chloro-2-[(1S)-2,2-dimethylcyclopropylcarboxamido]-2-heptenoic acid ethyl ester→2-[(1S)-2,2-Dimethylcyclopropylcarboxamido]-7-iodo-2-heptenoic acid ethyl ester→L-Cysteine methyl ester hydrochloride→7-[2(R)-Amino-3-methoxy-3-oxopropylsulfanyl]-2-(2,2-dimethylcyclopropylcarboxamido)-2-heptenoic acid ethyl ester
本站可供应的对应中间体
目录暂未收录该靶点的在售中间体 —— 可直接发起询价，需求会进入撮合池。
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。