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CAS 91400-03-2
(Z)-2-ethyl-N-hydroxybutanimidoyl chloride
登记编号：PERA-015
应用背景（按来源药适应症）
流感病毒感染帕拉米韦甲型流感病毒感染帕拉米韦乙型流感病毒感染帕拉米韦鼻塞帕拉米韦发热帕拉米韦咳嗽帕拉米韦
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 帕拉米韦Peramivir Hydrate | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
methyl (1S,4R)-4-((tert-butoxycarbonyl)amino)cyclopent-2-ene-1-carboxylate→methyl (3aR,4R,6S,6aS)-4-((tert-butoxycarbonyl)amino)-3-(pentan-3-yl)-3a,5,6,6a-tetrahydro-4H-cyclopenta[d]isoxazole-6-carboxylate→2-azabicyclo[2.2.1]hept-5-en-3-one→methyl (1S,4R)-4-aminocyclopent-2-ene-1-carboxylate (2R,3R)-2,3-dihydroxysuccinate→(Z)-2-ethyl-N-hydroxybutanimidoyl chloride→(3aR,4R,6S,6aS)-4-((tert-butoxycarbonyl)amino)-3-(pentan-3-yl)-3a,5,6,6a-tetrahydro-4H-cyclopenta[d]isoxazole-6-carboxylic acid→methyl (1S,2S,3S,4R)-3-((S)-1-aminoethyl)-4-((tert-butoxycarbonyl)amino)-2-hydroxycyclopentane-1-carboxylate
methyl (1S,4R)-4-aminocyclopent-2-ene-1-carboxylate (2R,3R)-2,3-dihydroxysuccinate→(Z)-2-ethyl-N-hydroxybutanimidoyl chloride→methyl (1S,2S,3R,4R)-3-((S)-1-acetamido-2-ethylbutyl)-4-((Z)-2,3-bis(tert-butoxycarbonyl)guanidino)-2-hydroxycyclopentane-1-carboxylate→(1S,2S,3R,4R)-3-((S)-1-acetamido-2-ethylbutyl)-4-((Z)-2,3-bis(tert-butoxycarbonyl)guanidino)-2-hydroxycyclopentane-1-carboxylic acid→(3R,3'R)-di-tert-butyl 3,3'-((((pyrimidine-4,6-dicarbonyl)bis(azanediyl))bis(2-(5-aminopentanamido)-4-(trifluoromethyl)-6,1-phenylene))bis(oxy))bis(pyrrolidine-1-carboxylate)→methyl (1S,4R)-4-((Z)-2,3-bis(tert-butoxycarbonyl)guanidino)cyclopent-2-ene-1-carboxylate→methyl (3aR,4R,6S,6aS)-4-((Z)-2,3-bis(tert-butoxycarbonyl)guanidino)-3-(pentan-3-yl)-3a,5,6,6a-tetrahydro-4H-cyclopenta[d]isoxazole-6-carboxylate
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