帕拉米韦

Q: 帕拉米韦的适应症有哪些？

已批准的适应症包括：流感病毒感染。

Tier C · 观察 / 贸易

Peramivir Hydrate

Biocryst Pharmaceuticals Inc

原研

2010

首批上市

到期年（公开口径）

$0.03B ▲

峰值销售

化学药

类型

靶点：NA

商品名：Rapiacta、Peramiflu、Enpiflu Premix、力纬、Alpivab、Rapivab

适应症（已批准）：流感病毒感染

各地区研发/上市状态

美国

批准上市

2014-12-19

欧盟

撤市

中国

批准上市

2013-04-05

日本

批准上市

2010-01-13

合成路线与中间体5 routes

原研路线 × 2优化路线（非专利）× 3工艺路线 × 0

路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。

原研Route 1步骤 7 · 总收率 1.22 g

编号	CAS 号	中间体名称
PERA-001	79200-56-9	(1R,4S)-2-azabicyclo[2.2.1]hept-5-en-3-one
PERA-002	138923-03-2	methyl (1S,4R)-4-aminocyclopent-2-ene-1-carboxylate
PERA-003	168683-02-1 在售	methyl (1S,4R)-4-((tert-butoxycarbonyl)amino)cyclopent-2-ene-1-carboxylate
PERA-004	7796-76-1	3-(nitromethyl)pentane
PERA-005	229613-93-8 在售	methyl (3aR,4R,6S,6aS)-4-((tert-butoxycarbonyl)amino)-3-(pentan-3-yl)-3a,5,6,6a-tetrahydro-4H-cyclopenta[d]isoxazole-6-carboxylate
PERA-006	316173-29-2	methyl (1S,2S,3S,4R)-3-((S)-1-amino-2-ethylbutyl)-4-((tert-butoxycarbonyl)amino)-2-hydroxycyclopentane-1-carboxylate
PERA-007	229614-05-5	methyl (1S,2S,3R,4R)-3-((S)-1-acetamido-2-ethylbutyl)-4-((tert-butoxycarbonyl)amino)-2-hydroxycyclopentane-1-carboxylate
PERA-008	229615-05-8	methyl (1S,2S,3R,4R)-3-((S)-1-acetamido-2-ethylbutyl)-4-amino-2-hydroxycyclopentane-1-carboxylate
PERA-009	4023-02-3	1H-pyrazole-1-carboximidamide hydrochloride

原研Route 5步骤 5 · 总收率 500 mg

编号	CAS 号	中间体名称
PERA-014	419563-22-7	methyl (1S,4R)-4-aminocyclopent-2-ene-1-carboxylate (2R,3R)-2,3-dihydroxysuccinate
PERA-015	91400-03-2	(Z)-2-ethyl-N-hydroxybutanimidoyl chloride
PERA-019	-	methyl (1S,2S,3R,4R)-3-((S)-1-acetamido-2-ethylbutyl)-4-((Z)-2,3-bis(tert-butoxycarbonyl)guanidino)-2-hydroxycyclopentane-1-carboxylate
PERA-020	-	(1S,2S,3R,4R)-3-((S)-1-acetamido-2-ethylbutyl)-4-((Z)-2,3-bis(tert-butoxycarbonyl)guanidino)-2-hydroxycyclopentane-1-carboxylic acid
PERA-021	152120-54-2	(3R,3'R)-di-tert-butyl 3,3'-((((pyrimidine-4,6-dicarbonyl)bis(azanediyl))bis(2-(5-aminopentanamido)-4-(trifluoromethyl)-6,1-phenylene))bis(oxy))bis(pyrrolidine-1-carboxylate)
PERA-022	-	methyl (1S,4R)-4-((Z)-2,3-bis(tert-butoxycarbonyl)guanidino)cyclopent-2-ene-1-carboxylate
PERA-023	-	methyl (3aR,4R,6S,6aS)-4-((Z)-2,3-bis(tert-butoxycarbonyl)guanidino)-3-(pentan-3-yl)-3a,5,6,6a-tetrahydro-4H-cyclopenta[d]isoxazole-6-carboxylate

优化Route 2步骤 7 · 总收率 0.91 g

编号	CAS 号	中间体名称
PERA-001	79200-56-9	(1R,4S)-2-azabicyclo[2.2.1]hept-5-en-3-one
PERA-002	138923-03-2	methyl (1S,4R)-4-aminocyclopent-2-ene-1-carboxylate
PERA-003	168683-02-1 在售	methyl (1S,4R)-4-((tert-butoxycarbonyl)amino)cyclopent-2-ene-1-carboxylate
PERA-005	229613-93-8 在售	methyl (3aR,4R,6S,6aS)-4-((tert-butoxycarbonyl)amino)-3-(pentan-3-yl)-3a,5,6,6a-tetrahydro-4H-cyclopenta[d]isoxazole-6-carboxylate
PERA-006	316173-29-2	methyl (1S,2S,3S,4R)-3-((S)-1-amino-2-ethylbutyl)-4-((tert-butoxycarbonyl)amino)-2-hydroxycyclopentane-1-carboxylate
PERA-007	229614-05-5	methyl (1S,2S,3R,4R)-3-((S)-1-acetamido-2-ethylbutyl)-4-((tert-butoxycarbonyl)amino)-2-hydroxycyclopentane-1-carboxylate
PERA-010	5399-18-8	(E)-2-ethylbutanal oxime
PERA-011	229614-17-9	methyl (1S,2S,3R,4R)-3-((S)-1-acetamido-2-ethylbutyl)-4-amino-2-hydroxycyclopentane-1-carboxylate hydrochloride
PERA-012	29671-92-9	carbamimidic chloride hydrochloride

优化Route 3步骤 6 · 总收率 49.8 g

编号	CAS 号	中间体名称
PERA-003	168683-02-1 在售	methyl (1S,4R)-4-((tert-butoxycarbonyl)amino)cyclopent-2-ene-1-carboxylate
PERA-005	229613-93-8 在售	methyl (3aR,4R,6S,6aS)-4-((tert-butoxycarbonyl)amino)-3-(pentan-3-yl)-3a,5,6,6a-tetrahydro-4H-cyclopenta[d]isoxazole-6-carboxylate
PERA-013	49805-30-3	2-azabicyclo[2.2.1]hept-5-en-3-one
PERA-014	419563-22-7	methyl (1S,4R)-4-aminocyclopent-2-ene-1-carboxylate (2R,3R)-2,3-dihydroxysuccinate
PERA-015	91400-03-2	(Z)-2-ethyl-N-hydroxybutanimidoyl chloride
PERA-016	316173-27-0	(3aR,4R,6S,6aS)-4-((tert-butoxycarbonyl)amino)-3-(pentan-3-yl)-3a,5,6,6a-tetrahydro-4H-cyclopenta[d]isoxazole-6-carboxylic acid
PERA-017	-	methyl (1S,2S,3S,4R)-3-((S)-1-aminoethyl)-4-((tert-butoxycarbonyl)amino)-2-hydroxycyclopentane-1-carboxylate

优化Route 4步骤 7 · 总收率 /

编号	CAS 号	中间体名称
PERA-001	79200-56-9	(1R,4S)-2-azabicyclo[2.2.1]hept-5-en-3-one
PERA-003	168683-02-1 在售	methyl (1S,4R)-4-((tert-butoxycarbonyl)amino)cyclopent-2-ene-1-carboxylate
PERA-004	7796-76-1	3-(nitromethyl)pentane
PERA-005	229613-93-8 在售	methyl (3aR,4R,6S,6aS)-4-((tert-butoxycarbonyl)amino)-3-(pentan-3-yl)-3a,5,6,6a-tetrahydro-4H-cyclopenta[d]isoxazole-6-carboxylate
PERA-007	229614-05-5	methyl (1S,2S,3R,4R)-3-((S)-1-acetamido-2-ethylbutyl)-4-((tert-butoxycarbonyl)amino)-2-hydroxycyclopentane-1-carboxylate
PERA-008	229615-05-8	methyl (1S,2S,3R,4R)-3-((S)-1-acetamido-2-ethylbutyl)-4-amino-2-hydroxycyclopentane-1-carboxylate
PERA-018	107819-90-9	tert-butyl N-[[(2-methylpropan-2-yl)oxycarbonylamino]-methylsulfanylmethylidene]carbamate
PERA-019	-	methyl (1S,2S,3R,4R)-3-((S)-1-acetamido-2-ethylbutyl)-4-((Z)-2,3-bis(tert-butoxycarbonyl)guanidino)-2-hydroxycyclopentane-1-carboxylate
PERA-020	-	(1S,2S,3R,4R)-3-((S)-1-acetamido-2-ethylbutyl)-4-((Z)-2,3-bis(tert-butoxycarbonyl)guanidino)-2-hydroxycyclopentane-1-carboxylic acid

常见问题（FAQ）

帕拉米韦的适应症有哪些？

已批准的适应症包括：流感病毒感染。

帕拉米韦的专利什么时候到期？

帕拉米韦的专利到期年暂无公开口径，本页会在数据管道核实后更新。

帕拉米韦有几条合成路线？

本站收录 5 条合成路线，最短路线 5 步、总收率 500 mg。每条路线的中间体均带登记编号与 CAS 号。

帕拉米韦的关键中间体在哪里可以采购？

帕拉米韦的多条路线中间体已挂接 CAS 档案，其中 2 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。

如何获取帕拉米韦中间体的报价？

在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。

数据来源：多源数据交叉核实（仅结构化字段） · 2026-09-24