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丙酸交沙霉素
Tier C · 观察 / 贸易Josamycin Propionate
奥瑞德光电股份有限公司
原研
1995
首批上市
-
到期年（公开口径）
无销量数据
峰值销售
化学药
类型
靶点：50S ribosomal subunit
适应症（已批准）：细菌感染、炎性疾病
各地区研发/上市状态
美国
-
欧盟
-
中国
批准上市
1995-01-01
日本
-
合成路线与中间体3 routes
原研路线 × 0优化路线（非专利）× 3工艺路线 × 0
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
优化Route 1步骤 13 · 总收率 /
Josamycin-001582-52-5Josamycin-002—Josamycin-003—Josamycin-004—Josamycin-005—Josamycin-006—Josamycin-0072605-67-6Josamycin-008—Josamycin-00976859-44-4Josamycin-010—Josamycin-01176859-46-6Josamycin-012—Josamycin-01376859-47-7Josamycin-014—Josamycin-01576859-48-8API · 丙酸交沙霉素
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Josamycin-001 | 582-52-5 | (3aR,5S,6S,6aR)-5-[(4R)-2,2-Dimethyl-1,3-dioxolan-4-yl]-2,2-dimethyltetrahydro-2H-furo[2,3-d][1,3]dioxol-6-ol |
| Josamycin-002 | - | (3aS,5S,6R,6aS)-5-[(4S)-2,2-Dimethyl-1,3-dioxolan-4-yl]-6-methoxy-2,2-dimethyltetrahydrofuro[2,3-d][1,3]dioxole |
| Josamycin-003 | - | 1,2-O-Isopropylidene-3-O-methyl-alpha-L-glucofuranose |
| Josamycin-004 | - | 6-O-Benzoyl-1,2-O-isopropylidene-3-O-methyl-alpha-L-glucofuranose |
| Josamycin-005 | - | 6-O-Benzoyl-1,2-O-isopropylidene-3-O-methyl-5-O-[(4-methylphenyl)sulfonyl]-alpha-L-glucofuranose |
| Josamycin-006 | - | 5-Deoxy-1,2-O-isopropylidene-3-O-methyl-alpha-L-xylo-hexofuranose |
| Josamycin-007 | 2605-67-6 | (Carbomethoxymethylene)triphenylphosphorane |
| Josamycin-008 | - | Methyl (2E)-2,3,7-trideoxy-5-O-methyl-D-xylo-oct-2-enonate |
| Josamycin-009 | 76859-44-4 | Methyl (2E)-2,3,7-trideoxy-4,6-O-isopropylidene-8-O-(methoxymethyl)-5-O-methyl-D-xylo-oct-2-enonate |
| Josamycin-010 | - | Methyl (4xi)-2,3,7-trideoxy-4,6-O-isopropylidene-8-O-(methoxymethyl)-5-O-methyl-3-[(methylsulfanyl)(methylsulfinyl)methyl]-D-lyxo-octonate |
| Josamycin-011 | 76859-46-6 | (4R,5S)-5-[(1S,2R)-2,4-Dihydroxy-1-methoxybutyl]-4-[(ethylsulfanyl)(methylsulfanyl)methyl]dihydrofuran-2(3H)-one |
| Josamycin-012 | - | 2,3,7-Trideoxy-3-[(ethylsulfanyl)(methylsulfanyl)methyl]-5-O-methyl-D-ido-octofuranose |
| Josamycin-013 | 76859-47-7 | Methyl 2,3,7-trideoxy-3-[(ethylsulfanyl)(methylsulfanyl)methyl]-5-O-methyl-D-ido-octofuranoside |
| Josamycin-014 | - | Methyl 6,8-di-O-benzyl-2,3,7-trideoxy-3-[(ethylsulfanyl)(methylsulfanyl)methyl]-5-O-methyl-D-ido-octofuranoside |
| Josamycin-015 | 76859-48-8 | Methyl 6,8-di-O-benzyl-2,3,7-trideoxy-3-formyl-5-O-methyl-D-ido-octofuranoside |
优化Route 2步骤 8 · 总收率 /
Josamycin-01576859-48-8Josamycin-01626487-92-3Josamycin-0174091-39-8Josamycin-018—Josamycin-019—Josamycin-020—Josamycin-021—Josamycin-022—Josamycin-023—Josamycin-024—Josamycin-025—API · 丙酸交沙霉素
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Josamycin-015 | 76859-48-8 | Methyl 6,8-di-O-benzyl-2,3,7-trideoxy-3-formyl-5-O-methyl-D-ido-octofuranoside |
| Josamycin-016 | 26487-92-3 | 3-(Triphenylphosphoranylidene)butan-2-one |
| Josamycin-017 | 4091-39-8 | 1-Acetyl-1-chloroethane |
| Josamycin-018 | - | Methyl 6,8-di-O-benzyl-2,3,7-trideoxy-5-O-methyl-3-[(1Z)-2-methyl-3-oxobut-1-en-1-yl]-D-ido-octofuranoside |
| Josamycin-019 | - | Methyl 2,3,7-trideoxy-5-O-methyl-3-(2-methyl-3-oxobutyl)-D-ido-octofuranoside |
| Josamycin-020 | - | Methyl 2,3,7-trideoxy-5-O-methyl-3-(2-methyl-3-oxobutyl)-D-ido-octofuranosiduronic acid |
| Josamycin-021 | - | Dimethyl 2,3,7-trideoxy-5-O-methyl-3-[(2R)-2-methyl-3-oxobutyl]-D-ido-octofuranosiduronate |
| Josamycin-022 | - | (2E)-5-Hydroxyhex-2-enal |
| Josamycin-023 | - | Dimethyl 2,3,7-trideoxy-3-[(2R,4E,6E,9R)-9-hydroxy-2-methyl-3-oxodeca-4,6-dien-1-yl]-5-O-methyl-D-ido-octofuranosiduronate |
| Josamycin-024 | - | Methyl 2,3,7-trideoxy-3-[(2R,4E,6E,9R)-3,9-dihydroxy-2-methyldeca-4,6-dien-1-yl]-5-O-methyl-D-ido-octofuranosiduronic acid |
| Josamycin-025 | - | Methyl S-phenyl 2,3,7-trideoxy-3-[(2R,4E,6E,9R)-3,9-dihydroxy-2-methyldeca-4,6-dien-1-yl]-5-O-methyl-8-thio-D-ido-octofuranosiduronate |
优化Route 3步骤 5 · 总收率 /
Josamycin-025—Josamycin-02676859-54-6Josamycin-027—Josamycin-028—Josamycin-029—Josamycin-030—API · 丙酸交沙霉素
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Josamycin-025 | - | Methyl S-phenyl 2,3,7-trideoxy-3-[(2R,4E,6E,9R)-3,9-dihydroxy-2-methyldeca-4,6-dien-1-yl]-5-O-methyl-8-thio-D-ido-octofuranosiduronate |
| Josamycin-026 | 76859-54-6 | (3aR,5R,7E,9E,12R,16R,17S,17aS)-6,16-Dihydroxy-2,17-dimethoxy-5,12-dimethyl-2,3,3a,4,5,6,11,12,15,16,17,17a-dodecahydro-14H-furo[2,3-f]oxacyclohexadecin-14-one |
| Josamycin-027 | - | (3aR,5R,7E,9E,12R,16R,17S,17aS)-16-Hydroxy-2,17-dimethoxy-5,12-dimethyl-3,3a,11,12,15,16,17,17a-octahydro-4H-furo[2,3-f]oxacyclohexadecine-6,14(2H,5H)-dione |
| Josamycin-028 | - | (3aR,5R,7E,9E,12R,16R,17S,17aS)-2,17-Dimethoxy-5,12-dimethyl-6,14-dioxo-2,3,3a,5,6,11,12,14,15,16,17,17a-dodecahydro-4H-furo[2,3-f]oxacyclohexadecin-16-yl acetate |
| Josamycin-029 | - | (3aR,5R,7E,9E,12R,16R,17S,17aS)-2-Hydroxy-17-methoxy-5,12-dimethyl-6,14-dioxo-2,3,3a,5,6,11,12,14,15,16,17,17a-dodecahydro-4H-furo[2,3-f]oxacyclohexadecin-16-yl acetate |
| Josamycin-030 | - | (4R,5R,6S,7R,9R,11E,13E,16R)-7-(1,3-Dioxolan-2-ylmethyl)-6-hydroxy-5-methoxy-9,16-dimethyl-2,10-dioxooxacyclohexadeca-11,13-dien-4-yl acetate |
常见问题（FAQ）
丙酸交沙霉素的适应症有哪些？
已批准的适应症包括：细菌感染、炎性疾病。
丙酸交沙霉素的专利什么时候到期？
丙酸交沙霉素的专利到期年暂无公开口径，本页会在数据管道核实后更新。
丙酸交沙霉素有几条合成路线？
本站收录 3 条合成路线，最短路线 5 步、总收率 /。每条路线的中间体均带登记编号与 CAS 号。
丙酸交沙霉素的关键中间体在哪里可以采购？
丙酸交沙霉素路线中的中间体均已建立 CAS 档案，可直接按 CAS 发起询价，需求会进入供应网络撮合池。
如何获取丙酸交沙霉素中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-10-04