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Tier C · 观察 / 贸易Finerenone · 2030 年到期全部品种 →
拜耳
原研
2021
首批上市
2030
到期年（公开口径）
$0.94B ▲
峰值销售
化学药
类型
靶点：MR
商品名：Kerendia、可申达、Firialta、KERENDIA
适应症（已批准）：收缩性心力衰竭、舒张期心力衰竭、心脏衰竭、慢性肾功能不全、糖尿病肾病、二型糖尿病、心肌梗塞、心脏性猝死
各地区研发/上市状态
美国
批准上市
2021-07-09
欧盟
批准上市
2022-02-16
中国
批准上市
2022-06-28
日本
批准上市
2022-03-28
合成路线与中间体35 routes
原研路线 × 1优化路线（非专利）× 34工艺路线 × 0
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
原研Route 1步骤 7 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| FINE-001 | 959934-76-0在售 | tert-butyl (E)-3-(4-cyano-2-methoxyphenyl)acrylate |
| FINE-002 | 21962-45-8在售 | 4-formyl-3-methoxybenzonitrile |
| FINE-003 | 65193-87-5在售 | 2-cyanoethyl 3-oxobutanoate |
| FINE-004 | 1050477-39-8在售 | 2-cyanoethyl (Z)-2-(4-cyano-2-methoxybenzylidene)-3-oxobutanoate |
| FINE-005 | 95306-64-2在售 | 4-amino-5-methylpyridin-2(1H)-one |
| FINE-006 | 1050477-43-4在售 | 2-cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate |
| FINE-007 | 1050477-44-5在售 | 2-cyanoethyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| FINE-008 | 1050477-45-6在售 | 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid |
| FINE-009 | 1050477-27-4在售 | 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide |
优化Route 2步骤 5 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)90859-10-a | 18368-64-4在售 | 2-Chloro-5-methylpyridine |
| (II)90859-10-a | 20173-49-3在售 | 2-Chloro-5-methyl-1-oxidopyridin-1-ium |
| (III)90859-10-a | 60323-96-8在售 | 2-Chloro-5-methyl-4-nitro-1-oxidopyridin-1-ium |
| (IV)90859-10-a | 79055-62-2在售 | 2-Chloro-5-methylpyridin-4-amine |
| (V)90859-10-a | 95306-64-2在售 | 4-Amino-5-methylpyridin-2(1H)-one |
| (VI)90859-10-a | 1663-67-8在售 | 1,3-Dichloro-1,3-propanedione |
| (VII)90859-10-a | 107-12-0在售 | Ethyl cyanide |
| (VIII)90859-10-a | 95306-65-3在售 | 6-Chloro-5-methylpyridine-2,4-diol hydrogen chloride (1/1) |
| (IX)90859-10-a | 41935-71-1在售 | 2,4-Dihydroxy-5-methylpyridine |
| (X)90859-10-a | 1260663-96-4在售 | 2-Methoxy-5-methylpyridin-4-amine |
优化Route 3步骤 7 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)638294-1-a | 5394-63-8在售 | 2,2-Dimethyl-6-methyl-1,3-dioxin-4-one |
| (II)638294-1-a | 109-78-4在售 | 1-Cyano-2-hydroxyethane |
| (III)638294-1-a | 65193-87-5在售 | 2-Cyanoethyl 3-oxobutanoate |
| (IV)638294-1-a,(IV)638294-1-b,(IV)638294-1-c,(IV)638294-1-d,(IV)638294-1-e | 21962-45-8在售 | 2-Methoxy-4-cyanobenzaldehyde |
| (V)638294-1-a | 1870824-80-8在售 | 2-Cyanoethyl (2Z)-2-[(4-cyano-2-methoxyphenyl)methylene]-3-oxobutanoate |
| (VI)638294-1-a,(VI)638294-1-e | 95306-64-2在售 | 4-Amino-5-methylpyridin-2(1H)-one |
| (VII)638294-1-a | 1050477-43-4在售 | 2-Cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate |
| (VIIIa)638294-1-a | 122-51-0在售 | (Diethoxymethoxy)ethane |
| (VIIIb)638294-1-a,(VIIIb)638294-1-e | 78-39-7在售 | 1,1,1-Triethoxyethane |
| (IX)638294-1-a | 1050477-44-5在售 | 2-Cyanoethyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (X)638294-1-a,(X)638294-1-e | 1050477-45-6在售 | 4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid |
| (XI)638294-1-a | 1050477-27-4在售 | (±)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide |
| (XII)638294-1-a | 2084136-51-4在售 | 4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,6-naphthyridine-3-carboxamide |
优化Route 4步骤 4 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (IV)638294-1-a,(IV)638294-1-b,(IV)638294-1-c,(IV)638294-1-d,(IV)638294-1-e | 21962-45-8在售 | 2-Methoxy-4-cyanobenzaldehyde |
| (XIII)638294-1-b | 121-33-5在售 | 4-Formyl-2-methoxyphenol |
| (XIV)638294-1-b | 4421-08-3在售 | 4-Cyano-2-methoxyphenol |
| (XV)638294-1-b | 652997-57-4在售 | 4-Cyano-2-methoxyphenyl trifluoromethanesulfonate |
| (XVI)638294-1-b | 1663-39-4在售 | 1,1-Dimethylethyl 2-propenoate |
| (XVII)638294-1-b | - | tert-Butyl (2Z)-3-(4-cyano-2-methoxyphenyl)acrylate |
| (XVIII)638294-1-b | 72135-36-5在售 | 4-Bromo-2-methoxybenzoic acid |
| (XIX)638294-1-b | 139102-34-4在售 | 2-Methoxy-4-bromobenzoic acid methyl ester |
| (XX)638294-1-b | 43192-33-2在售 | 4-Bromo-2-methoxybenzaldehyde |
优化Route 5步骤 6 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (IV)638294-1-a,(IV)638294-1-b,(IV)638294-1-c,(IV)638294-1-d,(IV)638294-1-e | 21962-45-8在售 | 2-Methoxy-4-cyanobenzaldehyde |
| (XXIV)638294-1-c,(XXIV)638294-1-d | 3556-60-3在售 | 3-Methoxy-4-methylbenzonitrile |
| (XXV)638294-1-c | 914106-35-7在售 | 4-(Dibromomethyl)-3-methoxybenzonitrile |
| (XXVI)638294-1-c | 104436-60-4在售 | 4-(Bromomethyl)-3-methoxybenzonitrile |
| (XXVII)638294-1-c | - | 1-[(4-Cyano-2-methoxyphenyl)methyl]-1,3,5,7-tetraazatricyclo[3.3.1.1(3,7)]decan-1-ium bromide |
| (XXI)638294-1-c | 7151-68-0在售 | 3-Methoxy-4-methylbenzoic acid |
| (XXII)638294-1-c | 87808-44-4在售 | 3-Methoxy-4-methylbenzoyl chloride |
| (XXIII)638294-1-c | 1017082-75-5在售 | 3-Methoxy-4-methylbenzamide |
优化Route 6步骤 4 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (IV)638294-1-a,(IV)638294-1-b,(IV)638294-1-c,(IV)638294-1-d,(IV)638294-1-e | 21962-45-8在售 | 2-Methoxy-4-cyanobenzaldehyde |
| (XXIV)638294-1-c,(XXIV)638294-1-d | 3556-60-3在售 | 3-Methoxy-4-methylbenzonitrile |
| (XXVIII)638294-1-d | 99-06-9在售 | 3-Carboxyphenol |
| (XXIX)638294-1-d | 618-49-5在售 | 3-Hydroxybenzamide |
| (XXX)638294-1-d | 873-62-1在售 | 3-Cyanophenol |
| (XXXI)638294-1-d | 50-00-0在售 | Formaldehyde |
| (XXXII)638294-1-d | 84102-89-6在售 | 4-Cyano-2-hydroxybenzaldehyde |
| (XXXIII)638294-1-d | 77-78-1在售 | Dimethoxysulfone |
| (XXXIV)638294-1-d | 74-88-4在售 | Iodomethane |
| (XXXV)638294-1-d | 170572-49-3在售 | 2-Fluoro-4-cyanotoluene |
| (XXXVI)638294-1-d | 67-56-1在售 | Hydroxymethane |
| (XXXVII)638294-1-d | 176961-57-2在售 | 4-Bromo-3-methoxybenzamide |
| (XXXVIII)638294-1-d,(XXXVIII)638294-1-e | 120315-65-3在售 | 2-Methoxy-4-cyanobromobenzene |
优化Route 7步骤 4 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (IV)638294-1-a,(IV)638294-1-b,(IV)638294-1-c,(IV)638294-1-d,(IV)638294-1-e | 21962-45-8在售 | 2-Methoxy-4-cyanobenzaldehyde |
| (VI)638294-1-a,(VI)638294-1-e | 95306-64-2在售 | 4-Amino-5-methylpyridin-2(1H)-one |
| (VIIIb)638294-1-a,(VIIIb)638294-1-e | 78-39-7在售 | 1,1,1-Triethoxyethane |
| (X)638294-1-a,(X)638294-1-e | 1050477-45-6在售 | 4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid |
| (XL)638294-1-e | 3092281-06-3在售 | 2,8-Dimethyl-5-oxo-5,6-dihydro-1,6-naphthyridine-3-carbonitrile |
| (XLI)638294-1-e | - | 4-(4-Cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carbonitrile |
| (XLII)638294-1-e | 2469-99-0在售 | 1-Cyano-2-propanone |
| (XLIII)638294-1-e | - | 4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carbonitrile |
| (XXXIX)638294-1-e | 22163-77-5在售 | 2-Methylidene-3-oxobutanenitrile |
| (XXXVIII)638294-1-d,(XXXVIII)638294-1-e | 120315-65-3在售 | 2-Methoxy-4-cyanobromobenzene |
优化Route 8步骤 7 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)638294-2-a | 1666-28-0在售 | 4-Bromo-2-hydroxybenzoic acid |
| (II)638294-2-a | 139102-34-4在售 | 2-Methoxy-4-bromobenzoic acid methyl ester |
| (III)638294-2-a | 43192-33-2在售 | 4-Bromo-2-methoxybenzaldehyde |
| (IV)638294-2-a | 21962-45-8在售 | 2-Methoxy-4-cyanobenzaldehyde |
| (V)638294-2-a | 5977-14-0在售 | 3-Oxobutanamide |
| (VI)638294-2-a | 2087452-79-5在售 | (2E)-2-[(4-Cyano-2-methoxyphenyl)methylidene]-3-oxobutanamide |
| (VII)638294-2-a | 2087452-80-8在售 | (2Z)-2-[(4-Cyano-2-methoxyphenyl)methylidene]-3-oxobutanamide |
| (VIII)638294-2-a | 95306-64-2在售 | 4-Amino-5-methylpyridin-2(1H)-one |
| (IX)638294-2-a | 2087452-81-9在售 | 4-(4-Cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxamide |
| (X)638294-2-a | 78-39-7在售 | 1,1,1-Triethoxyethane |
| (XI)638294-2-a | 1050477-27-4在售 | (±)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide |
| (XII)638294-2-a | 41935-71-1在售 | 2,4-Dihydroxy-5-methylpyridine |
| (XIII)638294-2-a | 100-46-9在售 | 1-Phenylmethylamine |
| (XIV)638294-2-a | 61190-99-6在售 | 4-(Benzylamino)-5-methylpyridin-2(1H)-one |
优化Route 9步骤 7 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)638294-3-a,(I)638294-3-b | 95306-64-2在售 | 4-Amino-5-methylpyridin-2(1H)-one |
| (II)638294-3-a | 75-03-6在售 | 1-Iodoethane |
| (III)638294-3-a | 1545905-35-8在售 | 2-Ethoxy-5-methylpyridin-4-amine |
| (IV)638294-3-a | 2569527-38-2在售 | N-(2-Ethoxy-5-methylpyridin-4-yl)-2,2-dimethylpropanamide |
| (V)638294-3-a | 21962-45-8在售 | 2-Methoxy-4-cyanobenzaldehyde |
| (VI)638294-3-a | 2569527-39-3在售 | N-[3-[(4-Cyano-2-methoxyphenyl)(hydroxy)methyl]-2-ethoxy-5-methylpyridin-4-yl]-2,2-dimethylpropanamide |
| (VII)638294-3-a | 2569527-40-6在售 | 4-[(4-Amino-2-ethoxy-5-methylpyridin-3-yl)(hydroxy)methyl]-3-methoxybenzonitrile |
| (VIII)638294-3-a | 5977-14-0在售 | 3-Oxobutanamide |
| (IX)638294-3-a,(IX)638294-3-b | 1050477-27-4在售 | (±)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide |
| (X)638294-3-a | 2084136-51-4在售 | 4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,6-naphthyridine-3-carboxamide |
| (A)638294-3-a | - | (aS)-10,16-Di(anthracen-9-yl)-13-hydroxy-12,14-dioxa-13lambda5-phosphapentacyclo[13.8.0.02,11.03,8.018,23]tricosa-1(15),2(11),3,5,7,9,16,18,20,22-decaene 13-oxide |
优化Route 10步骤 4 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)638294-3-a,(I)638294-3-b | 95306-64-2在售 | 4-Amino-5-methylpyridin-2(1H)-one |
| (IX)638294-3-a,(IX)638294-3-b | 1050477-27-4在售 | (±)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide |
| (XI)638294-3-b | 43192-33-2在售 | 4-Bromo-2-methoxybenzaldehyde |
| (XII)638294-3-b | 2469-99-0在售 | 1-Cyano-2-propanone |
| (XIII)638294-3-b | - | 4-(4-Bromo-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carbonitrile |
| (XIV)638294-3-b | 122-51-0在售 | (Diethoxymethoxy)ethane |
| (XV)638294-3-b | - | 4-(4-Bromo-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carbonitrile |
| (XVI)638294-3-b | - | 4-(4-Bromo-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide |
优化Route 11步骤 5 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)638294-4-a | 95306-64-2在售 | 4-Amino-5-methylpyridin-2(1H)-one |
| (II)638294-4-a | 21962-45-8在售 | 2-Methoxy-4-cyanobenzaldehyde |
| (III)638294-4-a | 105-53-3在售 | Carbethoxyacetic ester |
| (IV)638294-4-a | 2764833-06-7在售 | Ethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate |
| (V)638294-4-a | 122-51-0在售 | (Diethoxymethoxy)ethane |
| (VI)638294-4-a | 2764833-07-8在售 | Ethyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (VII)638294-4-a | 2764833-08-9在售 | 4-(5-Ethoxy-3-formyl-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-4-yl)-3-methoxybenzonitrile |
| (VIII)638294-4-a | 2764833-09-0在售 | Ethyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (A)638294-4-a | 2135478-70-3在售 | (5aR,10bS)-2-(2,6-Dimethoxyphenyl)-6,10b-dihydro-4H,5aH-indeno[2,1-b][1,2,4]triazolo[4,3-d][1,4]oxazin-2-ium tetrafluoridoborate(1-) |
优化Route 12步骤 5 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)638294-5-a | 5394-63-8在售 | 2,2-Dimethyl-6-methyl-1,3-dioxin-4-one |
| (IIa)638294-5-a | 61312-32-1在售 | (4-Methylphenyl)methyl 3-oxobutanoate |
| (IIb)638294-5-a | 5396-89-4在售 | 3-Oxobutyric acid benzyl ester |
| (IIc)638294-5-a | 1694-31-1在售 | 1,1-Dimethylethyl 3-oxobutanoate |
| (IId)638294-5-a | 2974322-13-7在售 | Bicyclo[2.2.1]hept-5-en-2-yl 3-oxobutanoate |
| (IIe)638294-5-a | 174654-67-2在售 | 2-(4-Nitrophenyl)ethyl 3-oxobutanoate |
| (III)638294-5-a | 21962-45-8在售 | 2-Methoxy-4-cyanobenzaldehyde |
| (IVa)638294-5-a | - | (4-Methylphenyl)methyl 2-[(4-cyano-2-methoxyphenyl)methylidene]-3-oxobutanoate |
| (IVb)638294-5-a | - | 2-[(4-Cyano-2-methoxyphenyl)methylene]-3-oxobutanoic acid phenylmethyl ester |
| (IVc)638294-5-a | - | tert-Butyl 2-[(4-cyano-2-methoxyphenyl)methylidene]-3-oxobutanoate |
| (IVd)638294-5-a | - | Bicyclo[2.2.1]hept-5-en-2-yl 2-[(4-cyano-2-methoxyphenyl)methylidene]-3-oxobutanoate |
| (IVe)638294-5-a | - | 2-(4-Nitrophenyl)ethyl 2-[(4-cyano-2-methoxyphenyl)methylidene]-3-oxobutanoate |
| (V)638294-5-a | 95306-64-2在售 | 4-Amino-5-methylpyridin-2(1H)-one |
| (VIa)638294-5-a | - | (4-Methylphenyl)methyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate |
| (VIb)638294-5-a | 2389020-00-0在售 | Benzyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate |
| (VIc)638294-5-a | - | tert-Butyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate |
| (VId)638294-5-a | - | Bicyclo[2.2.1]hept-5-en-2-yl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate |
| (VIe)638294-5-a | - | 2-(4-Nitrophenyl)ethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate |
| (VIIa)638294-5-a | 122-51-0在售 | (Diethoxymethoxy)ethane |
| (VIIb)638294-5-a | 78-39-7在售 | 1,1,1-Triethoxyethane |
| (VIIIa)638294-5-a | - | (4-Methylphenyl)methyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (VIIIb)638294-5-a,(VIIIb)638294-5-b | - | Benzyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (VIIIc)638294-5-a | - | tert-Butyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (VIIId)638294-5-a,(VIIId)638294-5-b | - | 2-(4-Nitrophenyl)ethyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (IXa)638294-5-a | - | (4-Methylphenyl)methyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (IXb)638294-5-a | - | Benzyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (IXc)638294-5-a | - | tert-Butyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (IXd)638294-5-a | - | Bicyclo[2.2.1]hept-5-en-2-yl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (IXe)638294-5-a | - | 2-(4-Nitrophenyl)ethyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (X)638294-5-a,(X)638294-5-b | 2640506-74-5在售 | (4S)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid |
| (XIa)638294-5-a | - | Benzyl (4S)-4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate |
| (XIb)638294-5-a | - | Bicyclo[2.2.1]hept-5-en-2-yl (4S)-4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate |
优化Route 13步骤 3 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (VIIIb)638294-5-a,(VIIIb)638294-5-b | - | Benzyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (VIIId)638294-5-a,(VIIId)638294-5-b | - | 2-(4-Nitrophenyl)ethyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (X)638294-5-a,(X)638294-5-b | 2640506-74-5在售 | (4S)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid |
| (XII)638294-5-b | 1050477-45-6在售 | 4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid |
| (XIII)638294-5-b | 1050477-27-4在售 | (±)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide |
优化Route 14步骤 7 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)638294-6-a | 43192-33-2在售 | 4-Bromo-2-methoxybenzaldehyde |
| (II)638294-6-a | 65193-87-5在售 | 2-Cyanoethyl 3-oxobutanoate |
| (III)638294-6-a | - | 2-Cyanoethyl (2Z)-2-[(4-bromo-2-methoxyphenyl)methylidene]-3-oxobutanoate |
| (IV)638294-6-a | 95306-64-2在售 | 4-Amino-5-methylpyridin-2(1H)-one |
| (V)638294-6-a | - | 2-Cyanoethyl 4-(4-bromo-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate |
| (VI)638294-6-a | - | 2-Cyanoethyl (4S)-4-(4-bromo-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate |
| (VII)638294-6-a | 122-51-0在售 | (Diethoxymethoxy)ethane |
| (VIII)638294-6-a | - | 2-Cyanoethyl (4S)-4-(4-bromo-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (IX)638294-6-a | - | (4S)-4-(4-Bromo-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid |
| (X)638294-6-a | - | (4S)-4-(4-Bromo-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide |
优化Route 15步骤 6 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)638294-7-a | 5977-14-0在售 | 3-Oxobutanamide |
| (II)638294-7-a | - | N-Boc-acetoacetamide |
| (III)638294-7-a | 21962-45-8在售 | 2-Methoxy-4-cyanobenzaldehyde |
| (IV)638294-7-a | - | N-Boc-2-[(4-cyano-2-methoxyphenyl)methylidene]-3-oxobutanamide |
| (V)638294-7-a | 95306-64-2在售 | 4-Amino-5-methylpyridin-2(1H)-one |
| (VI)638294-7-a | - | tert-Butyl [4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carbonyl]carbamate |
| (VII)638294-7-a | 110-71-4在售 | 1,2-Dimethoxyethane |
| (VIII)638294-7-a | - | (±)-tert-Butyl [4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carbonyl]carbamate |
| (IX)638294-7-a | - | tert-Butyl [(4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carbonyl]carbamate |
优化Route 16步骤 4 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)638294-8-a | 1050477-43-4在售 | 2-Cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate |
| (II)638294-8-a | - | 2-Cyanoethyl (4S)-4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate |
| (III)638294-8-a | 122-51-0在售 | (Diethoxymethoxy)ethane |
| (IV)638294-8-a | 2640574-73-6在售 | 2-Cyanoethyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (V)638294-8-a | 2640506-74-5在售 | (4S)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid |
| (VI)638294-8-a | 1050477-44-5在售 | 2-Cyanoethyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (VII)638294-8-a | - | 2-Cyanoethyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,6-naphthyridine-3-carboxylate |
优化Route 17步骤 6 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)638294-9-a | 21962-45-8在售 | 2-Methoxy-4-cyanobenzaldehyde |
| (II)638294-9-a | 58547-15-2在售 | 2,2,2-Trichloroethyl 3-oxobutanoate |
| (III)638294-9-a | - | 2,2,2-Trichloroethyl (2Z)-2-[(4-cyano-2-methoxyphenyl)methylidene]-3-oxobutanoate |
| (IV)638294-9-a | - | 2,2,2-Trichloroethyl (2E)-2-[(4-cyano-2-methoxyphenyl)methylidene]-3-oxobutanoate |
| (V)638294-9-a | 95306-64-2在售 | 4-Amino-5-methylpyridin-2(1H)-one |
| (VI)638294-9-a | - | 2,2,2-Trichloroethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate |
| (VII)638294-9-a | 122-51-0在售 | (Diethoxymethoxy)ethane |
| (VIII)638294-9-a | - | 2,2,2-Trichloroethyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (IX)638294-9-a | - | 2,2,2-Trichloroethyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (X)638294-9-a | 2640506-74-5在售 | (4S)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid |
优化Route 18步骤 4 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)638294-10-a | 43192-33-2在售 | 4-Bromo-2-methoxybenzaldehyde |
| (II)638294-10-a,(II)638294-10-b | 105-45-3在售 | 1-Methoxybutane-1,3-dione |
| (III)638294-10-a | - | Methyl (2Z)-2-[(4-bromo-2-methoxyphenyl)methylidene]-3-oxobutanoate |
| (IV)638294-10-a,(IV)638294-10-b | 95306-64-2在售 | 4-Amino-5-methylpyridin-2(1H)-one |
| (V)638294-10-a | - | Methyl 4-(4-bromo-2-methoxyphenyl)-5-hydroxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (VI)638294-10-a,(VI)638294-10-b | 122-51-0在售 | (Diethoxymethoxy)ethane |
| (VII)638294-10-a | - | Methyl 4-(4-bromo-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (VIII)638294-10-a | - | Methyl (4S)-4-(4-bromo-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (IX)638294-10-a,(IX)638294-10-b | - | Methyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (X)638294-10-a | 2640506-74-5在售 | (4S)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid |
优化Route 19步骤 5 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (II)638294-10-a,(II)638294-10-b | 105-45-3在售 | 1-Methoxybutane-1,3-dione |
| (IV)638294-10-a,(IV)638294-10-b | 95306-64-2在售 | 4-Amino-5-methylpyridin-2(1H)-one |
| (VI)638294-10-a,(VI)638294-10-b | 122-51-0在售 | (Diethoxymethoxy)ethane |
| (IX)638294-10-a,(IX)638294-10-b | - | Methyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (XI)638294-10-b | 105942-10-7在售 | 3-Fluoro-4-formylbenzonitrile |
| (XII)638294-10-b | - | Methyl 2-[(4-cyano-2-fluorophenyl)methylidene]-3-oxobutanoate |
| (XIII)638294-10-b | - | Methyl 4-(4-cyano-2-fluorophenyl)-5-hydroxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (XIV)638294-10-b | - | Methyl 4-(4-cyano-2-fluorophenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (XV)638294-10-b | - | Methyl (4S)-4-(4-cyano-2-fluorophenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (XVI)638294-10-b | 124-41-4在售 | Natrium methoxide |
优化Route 20步骤 8 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)638294-11-a | 21962-45-8在售 | 2-Methoxy-4-cyanobenzaldehyde |
| (II)638294-11-a | 22502-03-0在售 | 2-Methoxyethyl 3-oxobutanoate |
| (III)638294-11-a | - | 2-Methoxyethyl 2-[(4-cyano-2-methoxyphenyl)methylidene]-3-oxobutanoate |
| (IV)638294-11-a | 95306-64-2在售 | 4-Amino-5-methylpyridin-2(1H)-one |
| (V)638294-11-a | - | 2-Methoxyethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate |
| (VI)638294-11-a | 122-51-0在售 | (Diethoxymethoxy)ethane |
| (VII)638294-11-a | - | 2-Methoxyethyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (VIII)638294-11-a | 1050477-45-6在售 | 4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid |
| (IX)638294-11-a | - | 4-[5-Ethoxy-3-(1H-imidazole-1-carbonyl)-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-4-yl]-3-methoxybenzonitrile |
| (X)638294-11-a | - | (2S,3S)-2,3-Bis[(4-methylbenzoyl)oxy]butanedioic acid (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid (1/1) |
| (XIa)638294-11-a | 2640506-74-5在售 | (4S)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid |
| (XIb)638294-11-a | - | (2S,3S)-2,3-Bis(benzoyloxy)butanedioic acid (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid |
优化Route 21步骤 8 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)638294-12-a | 56-45-1在售 | (S)-2-Amino-3-hydroxypropanoic acid |
| (II)638294-12-a | 26348-61-8在售 | (S)-Ethyl 2-amino-3-hydroxypropanoate hydrochloride |
| (III)638294-12-a | 70930-18-6在售 | (S)-Ethyl 2-((tert-butoxycarbonyl)amino)-3-hydroxypropanoate |
| (IV)638294-12-a | 5394-63-8在售 | 2,2-Dimethyl-6-methyl-1,3-dioxin-4-one |
| (V)638294-12-a | - | (2S)-2-[(tert-Butoxycarbonyl)amino]-3-ethoxy-3-oxopropyl 3-oxobutanoate |
| (VI)638294-12-a | 21962-45-8在售 | 2-Methoxy-4-cyanobenzaldehyde |
| (VII)638294-12-a | - | (2S)-2-[(tert-Butoxycarbonyl)amino]-3-ethoxy-3-oxopropyl-2-[(4-cyano-2-methoxyphenyl)methylidene]-3-oxobutanoate |
| (VIII)638294-12-a | 95306-64-2在售 | 4-Amino-5-methylpyridin-2(1H)-one |
| (IX)638294-12-a | - | (2S)-2-[(tert-Butoxycarbonyl)amino]-3-ethoxy-3-oxopropyl 4-(4-cyano-2-methoxyphenyl)-5-hydroxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (X)638294-12-a | 122-51-0在售 | (Diethoxymethoxy)ethane |
| (XI)638294-12-a | - | (2S)-2-[(tert-Butoxycarbonyl)amino]-3-ethoxy-3-oxopropyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (XII)638294-12-a | - | (2S)-2-[(tert-Butoxycarbonyl)amino]-3-ethoxy-3-oxopropyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,6-naphthyridine-3-carboxylate |
| (XIII)638294-12-a | - | (2S)-2-[(tert-Butoxycarbonyl)amino]-3-ethoxy-3-oxopropyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
优化Route 22步骤 5 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)638294-13-a | 21962-45-8在售 | 2-Methoxy-4-cyanobenzaldehyde |
| (IIa)638294-13-a | 51719-12-1在售 | N-(4-Methoxybenzyl)acetoacetamide |
| (IIb)638294-13-a | 882-36-0在售 | 3-Oxo-N-(phenylmethyl)butanamide |
| (IIIa)638294-13-a | - | 2-[(4-Cyano-2-methoxyphenyl)methylidene]-N-[(4-methoxyphenyl)methyl]-3-oxobutanamide |
| (IIIb)638294-13-a | - | N-Benzyl-2-[(4-cyano-2-methoxyphenyl)methylidene]-3-oxobutanamide |
| (IV)638294-13-a | 95306-64-2在售 | 4-Amino-5-methylpyridin-2(1H)-one |
| (Va)638294-13-a | - | 4-(4-Cyano-2-methoxyphenyl)-N-[(4-methoxyphenyl)methyl]-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxamide |
| (Vb)638294-13-a | - | N-Benzyl-4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxamide |
| (VI)638294-13-a | 122-51-0在售 | (Diethoxymethoxy)ethane |
| (VIIa)638294-13-a | - | 4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-N-[(4-methoxyphenyl)methyl]-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide |
| (VIIb)638294-13-a | - | N-Benzyl-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide |
| (VIII)638294-13-a | 1050477-45-6在售 | 4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid |
| (IX)638294-13-a | 100-46-9在售 | 1-Phenylmethylamine |
| (Xa)638294-13-a | - | (4S)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-N-[(4-methoxyphenyl)methyl]-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide |
| (Xb)638294-13-a | - | (4S)-N-Benzyl-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide |
优化Route 23步骤 6 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)638294-14-a | 43192-33-2在售 | 4-Bromo-2-methoxybenzaldehyde |
| (II)638294-14-a | 5977-14-0在售 | 3-Oxobutanamide |
| (III)638294-14-a | - | (2Z)-2-[(4-Bromo-2-methoxyphenyl)methylidene]-3-oxobutanamide |
| (IV)638294-14-a | 95306-64-2在售 | 4-Amino-5-methylpyridin-2(1H)-one |
| (V)638294-14-a | - | 4-(4-Bromo-2-methoxyphenyl)-2,5-dihydroxy-2,8-dimethyl-1,2,3,4-tetrahydro-1,6-naphthyridine-3-carboxamide |
| (VI)638294-14-a | - | 4-(4-Bromo-2-methoxyphenyl)-5-hydroxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide |
| (VII)638294-14-a | 75-03-6在售 | 1-Iodoethane |
| (VIII)638294-14-a | - | 4-(4-Bromo-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide |
| (IX)638294-14-a | - | (4S)-4-(4-Bromo-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide |
优化Route 24步骤 5 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)638294-15-a | 21962-45-8在售 | 2-Methoxy-4-cyanobenzaldehyde |
| (II)638294-15-a | 29816-98-6在售 | 2,2,2-Trifluoroethyl 3-oxobutanoate |
| (III)638294-15-a | - | 2,2,2-Trifluoroethyl 2-[(4-cyano-2-methoxyphenyl)methylene]-3-oxo-butanoate |
| (IV)638294-15-a | 95306-64-2在售 | 4-Amino-5-methylpyridin-2(1H)-one |
| (V)638294-15-a | - | 2,2,2-Trifluoroethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate |
| (VI)638294-15-a | 122-51-0在售 | (Diethoxymethoxy)ethane |
| (VII)638294-15-a | - | 2,2,2-Trifluoroethyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (VIII)638294-15-a | 1050477-27-4在售 | (±)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide |
优化Route 25步骤 4 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)638294-16-a | 165336-55-0在售 | 1-[(4S)-4-Benzyl-2-oxo-1,3-oxazolidin-3-yl]butane-1,3-dione |
| (II)638294-16-a | 21962-45-8在售 | 2-Methoxy-4-cyanobenzaldehyde |
| (III)638294-16-a | 95306-64-2在售 | 4-Amino-5-methylpyridin-2(1H)-one |
| (IV)638294-16-a | - | 4-[(4S)-3-[(4S)-4-Benzyl-2-oxo-1,3-oxazolidine-3-carbonyl]-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridin-4-yl]-3-methoxybenzonitrile |
| (Va)638294-16-a | 122-51-0在售 | (Diethoxymethoxy)ethane |
| (Vb)638294-16-a | 78-39-7在售 | 1,1,1-Triethoxyethane |
| (VI)638294-16-a | - | 4-[(4S)-3-[(4S)-4-Benzyl-2-oxo-1,3-oxazolidine-3-carbonyl]-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-4-yl]-3-methoxybenzonitrile |
| (VII)638294-16-a | 2640506-74-5在售 | (4S)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid |
优化Route 26步骤 5 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)638294-17-a | 65193-87-5在售 | 2-Cyanoethyl 3-oxobutanoate |
| (II)638294-17-a | 21962-45-8在售 | 2-Methoxy-4-cyanobenzaldehyde |
| (III)638294-17-a | 1870824-80-8在售 | 2-Cyanoethyl (2Z)-2-[(4-cyano-2-methoxyphenyl)methylene]-3-oxobutanoate |
| (IV)638294-17-a | 95306-64-2在售 | 4-Amino-5-methylpyridin-2(1H)-one |
| (V)638294-17-a | 1050477-43-4在售 | 2-Cyanoethyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate |
| (VI)638294-17-a | - | 2-Cyanoethyl 4-(4-cyano-2-methoxyphenyl)-5-hydroxy-2,8-dimethyl-1,6-naphthyridine-3-carboxylate |
| (VII)638294-17-a | - | 2-Cyanoethyl (4S)-4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate |
| (VIIIa)638294-17-a | 122-51-0在售 | (Diethoxymethoxy)ethane |
| (VIIIb)638294-17-a | 78-39-7在售 | 1,1,1-Triethoxyethane |
| (IX)638294-17-a,(IX)638294-17-b | 2640574-73-6在售 | 2-Cyanoethyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
优化Route 27步骤 2 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (IX)638294-17-a,(IX)638294-17-b | 2640574-73-6在售 | 2-Cyanoethyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (X)638294-17-b | 2640506-74-5在售 | (4S)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid |
优化Route 28步骤 7 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)638294-18-a | 5394-63-8在售 | 2,2-Dimethyl-6-methyl-1,3-dioxin-4-one |
| (IIa)638294-18-a | 61312-84-3在售 | (4-Nitrophenyl)methyl 3-oxobutanoate |
| (IIb)638294-18-a | 61312-35-4在售 | (4-Methoxyphenyl)methyl 3-oxobutanoate |
| (III)638294-18-a | 21962-45-8在售 | 2-Methoxy-4-cyanobenzaldehyde |
| (IVa)638294-18-a | - | (4-Nitrophenyl)methyl (2E)-2-[(4-cyano-2-methoxyphenyl)methylidene]-3-oxobutanoate |
| (IVb)638294-18-a | - | (4-Methoxyphenyl)methyl (2E)-2-[(4-cyano-2-methoxyphenyl)methylidene]-3-oxobutanoate |
| (V)638294-18-a | 95306-64-2在售 | 4-Amino-5-methylpyridin-2(1H)-one |
| (VIa)638294-18-a | - | (4-Nitrophenyl)methyl 4-(4-cyano-2-methoxyphenyl)-5-hydroxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (VIb)638294-18-a | - | (4-Methoxyphenyl)methyl 4-(4-cyano-2-methoxyphenyl)-5-hydroxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (VII)638294-18-a | - | (4-Nitrophenyl)methyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-hydroxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (VIIIa)638294-18-a | 78-39-7在售 | 1,1,1-Triethoxyethane |
| (VIIIb)638294-18-a | 122-51-0在售 | (Diethoxymethoxy)ethane |
| (IXa)638294-18-a | - | (4-Nitrophenyl)methyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (IXb)638294-18-a | - | (4-Methoxyphenyl)methyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (Xa)638294-18-a | - | (4-Nitrophenyl)methyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (Xb)638294-18-a | - | (4-Methoxyphenyl)methyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (XI)638294-18-a | 2640506-74-5在售 | (4S)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid |
优化Route 29步骤 3 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)638294-19-a | 1050477-27-4在售 | (±)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide |
| (II)638294-19-a | 5470-11-1在售 | Amino alcohol hydrochloride |
| (III)638294-19-a | - | 5-Ethoxy-4-[4-[(hydroxyimino)methyl]-2-methoxyphenyl]-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide |
| (IV)638294-19-a | - | (4S)-5-Ethoxy-4-[4-[(hydroxyimino)methyl]-2-methoxyphenyl]-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide |
优化Route 30步骤 4 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)638294-20-a | 1050477-45-6在售 | 4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid |
| (II)638294-20-a | - | 4-[5-Ethoxy-3-(1H-imidazole-1-carbonyl)-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-4-yl]-3-methoxybenzonitrile |
| (III)638294-20-a | - | 4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-N-[(1S)-1-phenylethyl]-1,4-dihydro-1,6-naphthyridine-3-carboxamide |
| (IV)638294-20-a | - | (4S)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-N-[(1S)-1-phenylethyl]-1,4-dihydro-1,6-naphthyridine-3-carboxamide |
优化Route 31步骤 6 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)638294-21-a | 102029-44-7在售 | (R)-4-(Phenylmethyl)-2-oxazolidinone |
| (II)638294-21-a | 674-82-8在售 | 3-Hydroxy 3-butenoic acid beta-lactone |
| (III)638294-21-a | - | 1-[(4R)-4-Benzyl-2-oxo-1,3-oxazolidin-3-yl]butane-1,3-dione |
| (IV)638294-21-a | 21962-45-8在售 | 2-Methoxy-4-cyanobenzaldehyde |
| (V)638294-21-a | - | 4-[2-[(4R)-4-Benzyl-2-oxo-1,3-oxazolidine-3-carbonyl]-3-oxobut-1-en-1-yl]-3-methoxybenzonitrile |
| (VI)638294-21-a | 95306-64-2在售 | 4-Amino-5-methylpyridin-2(1H)-one |
| (VII)638294-21-a | - | 4-[3-[(4R)-4-Benzyl-2-oxo-1,3-oxazolidine-3-carbonyl]-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridin-4-yl]-3-methoxybenzonitrile |
| (VIII)638294-21-a | - | 4-[(4S)-3-[(4R)-4-Benzyl-2-oxo-1,3-oxazolidine-3-carbonyl]-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridin-4-yl]-3-methoxybenzonitrile |
| (IX)638294-21-a | 78-39-7在售 | 1,1,1-Triethoxyethane |
| (X)638294-21-a | - | 4-[(4S)-3-[(4R)-4-Benzyl-2-oxo-1,3-oxazolidine-3-carbonyl]-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-4-yl]-3-methoxybenzonitrile |
优化Route 32步骤 6 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)638294-22-a | 21962-45-8在售 | 2-Methoxy-4-cyanobenzaldehyde |
| (IIa)638294-22-a | - | 3-Ethoxy-3-oxopropyl 3-oxobutanoate |
| (IIb)638294-22-a | - | 4-Ethoxy-4-oxobutan-2-yl 3-oxobutanoate |
| (IIc)638294-22-a | - | (2R)-4-Ethoxy-4-oxobutan-2-yl 3-oxobutanoate |
| (IIIa)638294-22-a | - | 3-Ethoxy-3-oxopropyl 2-[(4-cyano-2-methoxyphenyl)methylidene]-3-oxobutanoate |
| (IIIb)638294-22-a | - | 4-Ethoxy-4-oxobutan-2-yl 2-[(4-cyano-2-methoxyphenyl)methylidene]-3-oxobutanoate |
| (IIIc)638294-22-a | - | (2R)-4-Ethoxy-4-oxobutan-2-yl 2-[(4-cyano-2-methoxyphenyl)methylidene]-3-oxobutanoate |
| (IV)638294-22-a | 95306-64-2在售 | 4-Amino-5-methylpyridin-2(1H)-one |
| (Va)638294-22-a | - | 3-Ethoxy-3-oxopropyl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate |
| (Vb)638294-22-a | - | 4-Ethoxy-4-oxobutan-2-yl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate |
| (Vc)638294-22-a | - | (2R)-4-Ethoxy-4-oxobutan-2-yl 4-(4-cyano-2-methoxyphenyl)-2,8-dimethyl-5-oxo-1,4,5,6-tetrahydro-1,6-naphthyridine-3-carboxylate |
| (VI)638294-22-a | 122-51-0在售 | (Diethoxymethoxy)ethane |
| (VIIa)638294-22-a | - | 3-Ethoxy-3-oxopropyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (VIIb)638294-22-a | - | 4-Ethoxy-4-oxobutan-2-yl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (VIIc)638294-22-a | - | (2R)-4-Ethoxy-4-oxobutan-2-yl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (VIIIa)638294-22-a | - | 3-Ethoxy-3-oxopropyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (VIIIb)638294-22-a | - | 4-Ethoxy-4-oxobutan-2-yl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (VIIIc)638294-22-a | - | (2R)-4-Ethoxy-4-oxobutan-2-yl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (IX)638294-22-a | 2640506-74-5在售 | (4S)-4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid |
优化Route 33步骤 3 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)638294-23-a | 1050477-45-6在售 | 4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid |
| (II)638294-23-a | - | 2,5-Dioxopyrrolidin-1-yl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (III)638294-23-a | - | 2,5-Dioxopyrrolidin-1-yl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
优化Route 34步骤 1 · 总收率 /
优化Route 35步骤 3 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| (I)638294-24-a | 1050477-45-6在售 | 4-(4-Cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid |
| (II)638294-24-a | - | Pentafluorophenyl 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
| (III)638294-24-a | - | Pentafluorophenyl (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylate |
常见问题（FAQ）
非奈利酮的适应症有哪些？
已批准的适应症包括：收缩性心力衰竭、舒张期心力衰竭、心脏衰竭、慢性肾功能不全、糖尿病肾病、二型糖尿病、心肌梗塞、心脏性猝死。
非奈利酮的专利什么时候到期？
按公开口径，非奈利酮的专利到期年为 2030 年。
非奈利酮有几条合成路线？
本站收录 35 条合成路线，最短路线 1 步、总收率 /。每条路线的中间体均带登记编号与 CAS 号。
非奈利酮的关键中间体在哪里可以采购？
非奈利酮的多条路线中间体已挂接 CAS 档案，其中 96 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。
如何获取非奈利酮中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-09-24