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盐酸伊伐布雷定
Tier C · 观察 / 贸易Ivabradine Hydrochloride
法国施维雅药厂
原研
2005
首批上市
-
到期年（公开口径）
无销量数据
峰值销售
化学药
类型
靶点：HCN channels
商品名：Coralan、Coraxan、Procoralan、Corlentor、Corlanor、可兰特
适应症（已批准）：心脏衰竭、心绞痛
各地区研发/上市状态
美国
撤市
欧盟
批准上市
2005-10-25
中国
批准上市
2015-04-29
日本
批准上市
2019-09-20
合成路线与中间体5 routes
原研路线 × 1优化路线（非专利）× 4工艺路线 × 0
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
原研Route 1步骤 7 · 总收率 0.5 g
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| IVAB-001 | 35202-54-1 | 3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-triene-7-carbonitrile |
| IVAB-002 | 73344-75-9 | (3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methanamine |
| IVAB-003 | 148870-55-7 | 1-(3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)-N-methylmethanamine |
| IVAB-004 | 148870-55-7 | 1-(3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)-N-methylmethanamine |
| IVAB-005 | 866783-12-2 | (S)-1-(3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)-N-methylmethanamine |
| IVAB-006 | 148870-57-9 | 3-(3-iodopropyl)-7,8-dimethoxy-1H-benzo[d]azepin-2(3H)-one |
| IVAB-007 | 1086026-31-4 | (S)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1,3,5-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1,3-dihydro-2H-benzo[d]azepin-2-one |
| IVAB-008 | 155974-00-8 | (S)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one |
优化Route 2步骤 4 · 总收率 0.95 g
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| IVAB-008 | 155974-00-8 | (S)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one |
| IVAB-009 | 73942-87-7 | 7,8-dimethoxy-1H-benzo[d]azepin-2(3H)-one |
| IVAB-010 | 1069115-30-5 | tert-butyl (3-chloropropyl)(methyl)carbamate |
| IVAB-011 | 1069115-32-7 | tert-butyl (3-(7,8-dimethoxy-2-oxo-1H-benzo[d]azepin-3(2H)-yl)propyl)(methyl)carbamate |
| IVAB-012 | 163629-94-5 | 7,8-dimethoxy-3-(3-(methylamino)propyl)-1H-benzo[d]azepin-2(3H)-one |
| IVAB-013 | 1206230-27-4 | 7-(iodomethyl)-3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-triene |
| IVAB-014 | 148870-58-0 | 3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1H-benzo[d]azepin-2(3H)-one |
优化Route 3步骤 5 · 总收率 270 mg
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| IVAB-004 | 148870-55-7 | 1-(3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)-N-methylmethanamine |
| IVAB-008 | 155974-00-8 | (S)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one |
| IVAB-015 | 5460-29-7 | 2-(3-bromopropyl)isoindoline-1,3-dione |
| IVAB-016 | 1393427-01-4 | (S)-2-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)isoindoline-1,3-dione |
| IVAB-017 | 1393427-02-5 | (S)-N1-((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)-N1-methylpropane-1,3-diamine |
| IVAB-018 | 51673-84-8 | 2,2-dimethoxyacetaldehyde |
| IVAB-019 | 1393427-03-6 | (S)-N1-((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)-N3-(2,2-dimethoxyethyl)-N1-methylpropane-1,3-diamine |
| IVAB-020 | 10313-60-7 | 2-(3,4-dimethoxyphenyl)acetyl chloride |
| IVAB-021 | 1393427-04-7 | (S)-N-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-N-(2,2-dimethoxyethyl)-2-(3,4-dimethoxyphenyl)acetamide |
优化Route 4步骤 5 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| IVAB-009 | 73942-87-7 | 7,8-dimethoxy-1H-benzo[d]azepin-2(3H)-one |
| IVAB-022 | 37895-73-1 | 3-bromopropanenitrile |
| IVAB-023 | 2678-54-8 | 3-(7,8-dimethoxy-2-oxo-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)propanenitrile |
| IVAB-024 | 1132079-01-6 | (S)-(3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methanamine hydrochloride |
| IVAB-025 | 1246638-10-7 | (S)-3-(7,8-dimethoxy-2-oxo-4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-N-((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)propanimidamide |
| IVAB-026 | 215935-23-2 | (S)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one |
| IVAB-027 | 1246672-58-1 | (S)-3-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)amino)propyl)-7,8-dimethoxy-4,5-dihydro-1H-benzo[d]azepin-2(3H)-one hydrochloride |
优化Route 5步骤 8 · 总收率 600 mg
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| IVAB-028 | 120-20-7在售 | 2-(3,4-dimethoxyphenyl)ethanamine |
| IVAB-029 | 98062-25-0 | tert-butyl (3,4-dimethoxyphenethyl)carbamate |
| IVAB-030 | 1031767-71-1 | (S)-3-chloro-N-((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)-N-methylpropan-1-amine |
| IVAB-031 | 1325209-22-0 | tert-butyl (S)-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)(3,4-dimethoxyphenethyl)carbamate |
| IVAB-032 | 1325209-23-1 | (S)-N1-((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)-N3-(3,4-dimethoxyphenethyl)-N1-methylpropane-1,3-diamine |
| IVAB-033 | 1325209-25-3 | (S)-2-((3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)(3,4-dimethoxyphenethyl)amino)-2-oxoethyl acetate |
| IVAB-034 | 1325209-24-2 | (S)-N-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-N-(3,4-dimethoxyphenethyl)-2-hydroxyacetamide |
| IVAB-035 | 1325209-26-4 | (S)-N-(3-(((3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-N-(3,4-dimethoxyphenethyl)-2-oxoacetamide |
| IVAB-036 | 1325209-27-5 | 3-(3-((((S)-3,4-dimethoxybicyclo[4.2.0]octa-1(6),2,4-trien-7-yl)methyl)(methyl)amino)propyl)-7,8-dimethoxy-1-(phenylthio)-1,3,4,5-tetrahydro-2H-benzo[d]azepin-2-one |
常见问题（FAQ）
盐酸伊伐布雷定的适应症有哪些？
已批准的适应症包括：心脏衰竭、心绞痛。
盐酸伊伐布雷定的专利什么时候到期？
盐酸伊伐布雷定的专利到期年暂无公开口径，本页会在数据管道核实后更新。
盐酸伊伐布雷定有几条合成路线？
本站收录 5 条合成路线，最短路线 4 步、总收率 0.95 g。每条路线的中间体均带登记编号与 CAS 号。
盐酸伊伐布雷定的关键中间体在哪里可以采购？
盐酸伊伐布雷定的多条路线中间体已挂接 CAS 档案，其中 1 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。
如何获取盐酸伊伐布雷定中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-09-24