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地文拉法辛
Tier C · 观察 / 贸易Desvenlafaxine
Alembic Ltd
原研
2008
首批上市
-
到期年（公开口径）
无销量数据
峰值销售
化学药
类型
靶点：NET、SERT
商品名：Desvenlafaxine、Khedezla
适应症（已批准）：重度抑郁症
各地区研发/上市状态
美国
批准上市
2013-03-04
欧盟
-
中国
无进展
2007-07-01
日本
临床三期
2020-05-18
合成路线与中间体10 routes
原研路线 × 0优化路线（非专利）× 8工艺路线 × 2
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
优化Route 1步骤 2 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Desvenlafaxine-001 | 93413-69-5 | Venlafaxine |
| Desvenlafaxine-002 | 99300-78-4 | Venlafaxine hydrochloride |
| Desvenlafaxine-003 | 93413-62-8 | Desvenlafaxine(O-Desnethylvenfaxine) |
优化Route 2步骤 5 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Desvenlafaxine-004 | 6547-53-1 | 2-[4-(benzyloxy)phenyl]acetic acid |
| Desvenlafaxine-005 | 39188-62-0 | 2-[4-(benzyloxy)phenyl]acetyl chloride |
| Desvenlafaxine-006 | 919475-15-3 | 2-[4-(benzyloxy)phenyl]-N,N-dimethylacetamide |
| Desvenlafaxine-007 | 108-94-1 | Cyclohexanone |
| Desvenlafaxine-008 | 955365-79-4 | 2-[4-(benzyloxy)phenyl]-2-(1-hydroxycyclohexyl)-N,N-dimethylacetamide |
| Desvenlafaxine-009 | - | 1-{1-[4-(Benzyloxy)phenyl]-2-(dimethylamino)ethyl}cyclohexan-1-ol |
优化Route 3步骤 7 · 总收率 5.8g(Desvenlafaxine (Free))
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Desvenlafaxine-010 | 156-38-7 | 2-(4-Hydroxyphenyl)acetic acid |
| Desvenlafaxine-011 | 37859-23-7 | 2-(4-Hydroxyphenyl)acetyl chloride |
| Desvenlafaxine-012 | 124-40-3在售 | Dimethylamine |
| Desvenlafaxine-013 | 76472-23-6 | 2-(4-Hydroxyphenyl)-N,N-dimethylacetamide |
| Desvenlafaxine-014 | 1004300-70-2 | 2-[4-[tert-Butyl(dimethyl)silyloxy]phenyl]-N,N-dimethylacetamide |
| Desvenlafaxine-007 | 108-94-1 | Cyclohexanone |
| Desvenlafaxine-015 | - | 2-[4-[tert-Butyl(dimethyl)silyloxy]phenyl]-2-(1-hydroxycyclohexyl)-N,N-dimethylacetamide |
| Desvenlafaxine-003 | 93413-62-8 | 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol |
| Desvenlafaxine-016 | 1004300-76-8 | 2-(1-Hydroxycyclohexyl)-2-(4-hydroxyphenyl)-N,N-dimethylacetamide |
优化Route 4步骤 10 · 总收率 82.4g(Desvenlafaxine succinate (API))
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Desvenlafaxine-017 | 14191-95-8 | 2-(4-Hydroxyphenyl)acetonitrile |
| Desvenlafaxine-007 | 108-94-1 | Cyclohexanone |
| Desvenlafaxine-018 | 918344-20-4 | (1-Hydroxycyclohexyl)(4-hydroxyphenyl)acetonitrile |
| Desvenlafaxine-019 | 149289-29-2 | 4-[2-Amino-1-(1-hydroxycyclohexyl)ethyl]phenol |
| Desvenlafaxine-020 | - | 2-[4-(Oxan-2-yloxy)phenyl]acetonitrile |
| Desvenlafaxine-021 | - | [4-(Benzyloxy)phenyl]acetonitrile |
| Desvenlafaxine-022 | - | 2-(1-Hydroxycyclohexyl)-2-[4-(oxan-2-yloxy)phenyl]acetonitrile |
| Desvenlafaxine-023 | - | [4-(Benzyloxy)phenyl](1-hydroxycyclohexyl)acetonitrile |
| Desvenlafaxine-024 | 74-88-4在售 | Iodomethane |
| Desvenlafaxine-003 | 93413-62-8 | 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol |
优化Route 6步骤 8 · 总收率 /
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Desvenlafaxine-025 | 16532-79-9 | 4-Bromophenylacetonitrile |
| Desvenlafaxine-026 | 9075-99-4 | Cyclohexanone,homopolymer |
| Desvenlafaxine-027 | - | 2-(4-bromophenyl)-2-(1-hydroxycyclohexyl)acetonitrile |
| Desvenlafaxine-028 | - | 1-(2-amino-1-(4-bromophenyl)ethyl)cyclohexanol |
| Desvenlafaxine-029 | - | 1-(1-(4-bromophenyl)-2-(dimethylamino)ethyl)cyclohexanol |
| Desvenlafaxine-030 | - | (4-(2-(dimethylamino)-1-(1-hydroxycyclohexyl)ethyl)phenyl)boronic acid |
| Desvenlafaxine-031 | - | 1-(1-(4-bromophenyl)-2-(dimethylamino)ethyl)cyclohexyl acetate |
优化Route 7步骤 8 · 总收率 82g(Desvenlafaxine succinate (API))
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Desvenlafaxine-032 | 104-47-2 | 2-(4-Methoxyphenyl)acetonitrile |
| Desvenlafaxine-017 | 14191-95-8 | 2-(4-Hydroxyphenyl)acetonitrile |
| Desvenlafaxine-033 | 160192-83-6 | [4-[(2-Methoxyethoxy)methoxy]phenyl]acetonitrile |
| Desvenlafaxine-007 | 108-94-1 | Cyclohexanone |
| Desvenlafaxine-034 | 1202929-75-6 | (1-Hydroxycyclohexyl)[4-[(2-methoxyethoxy)methoxy]phenyl]acetonitrile |
| Desvenlafaxine-035 | 506-59-2 | Dimethylamine hydrochloride |
| Desvenlafaxine-036 | 1202929-76-7 | - |
| Desvenlafaxine-003 | 93413-62-8 | 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol |
| Desvenlafaxine-018 | 918344-20-4 | (1-Hydroxycyclohexyl)(4-hydroxyphenyl)acetonitrile |
优化Route 8步骤 10 · 总收率 73.72g(Desvenlafaxine succinate (API))
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Desvenlafaxine-032 | 104-47-2 | 2-(4-Methoxyphenyl)acetonitrile |
| Desvenlafaxine-007 | 108-94-1 | Cyclohexanone |
| Desvenlafaxine-021 | 93413-76-4 | 2-(1-Hydroxycyclohexyl)-2-(4-methoxyphenyl)acetonitrile |
| Desvenlafaxine-023 | 93413-77-5 | 1-[2-Amino-1-(4-methoxyphenyl)ethyl]cyclohexanol |
| Desvenlafaxine-022 | 130198-05-9 | 1-[2-Amino-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride |
| Desvenlafaxine-024 | 93413-78-6,99300-78-4 | 1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride |
| Desvenlafaxine-001 | 93413-69-5 | 1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol |
| Desvenlafaxine-003 | 93413-62-8 | 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol |
| Desvenlafaxine-037 | 1000377-24-1 | 1-[2-(Dimethylamino)-1-[4-[(4-methoxybenzyl)oxy]phenyl]ethyl]cyclohexanol |
| Desvenlafaxine-009 | - | 1-{1-[4-(Benzyloxy)phenyl]-2-(dimethylamino)ethyl}cyclohexan-1-ol |
| Desvenlafaxine-038 | - | Butanedioic acid 1-[2-(dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexan-1-ol |
优化Route 9步骤 8 · 总收率 5.13g(Desvenlafaxine succinate (API))
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Desvenlafaxine-039 | 99-93-4 | 1-(4-Hydroxyphenyl)ethanone |
| Desvenlafaxine-040 | 54696-05-8 | 1-[4-(Benzyloxy)phenyl]ethanone |
| Desvenlafaxine-041 | 4254-67-5 | 1-[4-(benzyloxy)phenyl]-2-bromoethan-1-one |
| Desvenlafaxine-012 | 124-40-3在售 | Dimethylamine |
| Desvenlafaxine-042 | 1654001-15-6 | 1-[4-(Benzyloxy)phenyl]-2-(dimethylamino)ethanone hydrobromide |
| Desvenlafaxine-043 | 1654001-05-4 | 1-[4-(Benzyloxy)phenyl]-2-(dimethylamino)ethanol hydrochloride |
| Desvenlafaxine-044 | 1654001-18-9 | 2-[4-(Benzyloxy)phenyl]-2-chloro-N,N-dimethylethanamine hydrochloride |
| Desvenlafaxine-007 | 108-94-1 | Cyclohexanone |
| Desvenlafaxine-009 | - | 1-{1-[4-(Benzyloxy)phenyl]-2-(dimethylamino)ethyl}cyclohexan-1-ol |
| Desvenlafaxine-003 | 93413-62-8 | 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol |
工艺Route 5步骤 8 · 总收率 17.8kg(Desvenlafaxine succinate (API))
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Desvenlafaxine-021 | 93413-76-4 | 2-(1-Hydroxycyclohexyl)-2-(4-methoxyphenyl)acetonitrile |
| Desvenlafaxine-022 | 130198-05-9 | 1-[2-Amino-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride |
| Desvenlafaxine-023 | 93413-77-5 | 1-[2-Amino-1-(4-methoxyphenyl)ethyl]cyclohexanol |
| Desvenlafaxine-019 | 149289-29-2 | 4-[2-Amino-1-(1-hydroxycyclohexyl)ethyl]phenol |
| Desvenlafaxine-003 | 93413-62-8 | 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol |
| Desvenlafaxine-001 | 93413-69-5 | 1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol |
| Desvenlafaxine-024 | 93413-78-6,99300-78-4 | 1-[2-(Dimethylamino)-1-(4-methoxyphenyl)ethyl]cyclohexanol hydrochloride |
工艺Route 10步骤 4 · 总收率 1kg(Desvenlafaxine (Free))
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Desvenlafaxine-045 | 17362-17-3 | 3-(4-Hydroxyphenyl)propanenitrile |
| Desvenlafaxine-007 | 108-94-1 | Cyclohexanone |
| Desvenlafaxine-046 | - | 3-Cyclohexylidene-3-(4-hydroxyphenyl)propanenitrile |
| Desvenlafaxine-047 | - | [2-(4-Hydroxyphenyl)-1-oxaspiro[2.5]octan-2-yl]acetonitrile |
| Desvenlafaxine-019 | 149289-29-2 | 4-[2-Amino-1-(1-hydroxycyclohexyl)ethyl]phenol |
| Desvenlafaxine-003 | 93413-62-8 | 4-[2-(Dimethylamino)-1-(1-hydroxycyclohexyl)ethyl]phenol |
常见问题（FAQ）
地文拉法辛的适应症有哪些？
已批准的适应症包括：重度抑郁症。
地文拉法辛的专利什么时候到期？
地文拉法辛的专利到期年暂无公开口径，本页会在数据管道核实后更新。
地文拉法辛有几条合成路线？
本站收录 10 条合成路线，最短路线 2 步、总收率 /。每条路线的中间体均带登记编号与 CAS 号。
地文拉法辛的关键中间体在哪里可以采购？
地文拉法辛的多条路线中间体已挂接 CAS 档案，其中 2 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。
如何获取地文拉法辛中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-09-24