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利福平
Tier C · 观察 / 贸易Rifampicin
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原研
1971
首批上市
-
到期年（公开口径）
无销量数据
峰值销售
化学药
类型
靶点：RNAP
商品名：Rifadin、Rimactane、Rifa、Rifadine、Rimactan、Rifamsolin
适应症（已批准）：结核分枝杆菌感染、麻风分枝杆菌感染、肺结核、脑膜炎球菌性脑膜炎
各地区研发/上市状态
美国
批准上市
1971-05-21
欧盟
临床三期
2021-04-29
中国
批准上市
1981-01-01
日本
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生产该 API 的工厂3
口径：平台供应网络（富通询价明细 + 产品主档）中登记生产该品种的工厂（在产口径），按报价活跃度排序；快照不含成本与客户信息。
已收录 3 家在产工厂名单，登录后可见（工厂信息不对未登录访客展示）。
登录查看工厂名单 →合成路线与中间体5 routes
原研路线 × 0优化路线（非专利）× 5工艺路线 × 0
路线按「原研路线 → 优化路线 / 工艺路线（非专利）」排序。每条路线附本站自绘的路线流程图（中间体 → 原料药）与中间体表（编号 / CAS / 英文名），可直接用于供应商开发与询价。流程图由本站依据已授权的结构化数据自行渲染，未使用任何第三方路线图。
优化Route 1步骤 4 · 总收率 572g([11C]rifampicin (FREE))
Rifampicin-001110-85-0Rifampicin-0025632-47-3Rifampicin-00330651-60-6Rifampicin-00413292-22-3Rifampicin-00554245-42-0Rifampicin-006145577-00-0Rifampicin-0071001315-05-4Rifampicin-008—API · 利福平
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Rifampicin-001 | 110-85-0在售 | Piperazine |
| Rifampicin-002 | 5632-47-3 | 1-Nitrosopiperazine |
| Rifampicin-003 | 30651-60-6 | 1-Aminopiperazine |
| Rifampicin-004 | 13292-22-3 | 3-Formylrifamycin |
| Rifampicin-005 | 54245-42-0 | Iodo[11C]methane |
| Rifampicin-006 | 145577-00-0 | Trifluoromethanesulfonic acid [11C]methyl ester |
| Rifampicin-007 | 1001315-05-4 | Acetic acid (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-8-(piperazin-1-yliminomethyl)-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl ester |
| Rifampicin-008 | - | 3-(4-[11C]Methylpiperazin-1-yliminomethyl)rifamycin |
优化Route 2步骤 4 · 总收率 9.5g(Rifampicin (FREE))
Rifampicin-0096998-60-3,14897-39-3Rifampicin-01013553-79-2Rifampicin-01155686-22-1Rifampicin-013—Rifampicin-00413292-22-3Rifampicin-0126928-85-4API · 利福平
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Rifampicin-009 | 6998-60-3,14897-39-3 | (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-21-Acetoxy-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-1,11-dione |
| Rifampicin-010 | 13553-79-2 | (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17-Trihydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23,27,29-tetraoxo-8,30-dioxa-24-azatetracyclo[23.3.1.1(4,7).0(5,28)]triaconta-1(28),2,4,9,19,21,25-heptaen-13-yl acetate |
| Rifampicin-011 | 55686-22-1 | N,N-Dihydroxymethyl-t-butylamine |
| Rifampicin-013 | - | (10S,13E,15S,16R,17S,18R,19R,20R,21S,22S,23E,25Z)-17-(Acetyloxy)-3-tert-butyl-7,19,21-trihydroxy-15-methoxy-8,10,16,18,20,22,26-heptamethyl-11,27-dioxo-10,11-dihydro-2H-10,5-(epoxypentadeca[1,11,13]trienoimino)furo[2',3':7,8]naphtho[2,1-e][1,3]oxazin-3-ium-6-olate |
| Rifampicin-004 | 13292-22-3 | Acetic acid (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-formyl-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl ester |
| Rifampicin-012 | 6928-85-4 | 4-Methylpiperazin-1-amine |
优化Route 3步骤 2 · 总收率 /
Rifampicin-01013553-79-2Rifampicin-00413292-22-3Rifampicin-01450-00-0Rifampicin-0154075-42-7Rifampicin-0164267-47-4Rifampicin-0174075-43-8Rifampicin-0186695-52-9Rifampicin-0194075-48-3Rifampicin-0204075-44-9Rifampicin-0214075-41-6Rifampicin-0224135-85-7API · 利福平
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Rifampicin-010 | 13553-79-2 | (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17-Trihydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23,27,29-tetraoxo-8,30-dioxa-24-azatetracyclo[23.3.1.1(4,7).0(5,28)]triaconta-1(28),2,4,9,19,21,25-heptaen-13-yl acetate |
| Rifampicin-004 | 13292-22-3 | Acetic acid (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-formyl-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl ester |
| Rifampicin-014 | 50-00-0在售 | Formaldehyde |
| Rifampicin-015 | 4075-42-7 | (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,6,9,17,19-Pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-8-[(pyrrolidin-1-yl)methyl]-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate |
| Rifampicin-016 | 4267-47-4 | (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,6,9,17,19-Pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-8-[(piperidin-1-yl)methyl]-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate |
| Rifampicin-017 | 4075-43-8 | (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,6,9,17,19-Pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-[(morpholin-4-yl)methyl]-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate |
| Rifampicin-018 | 6695-52-9 | 1-[[(2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-21-(Acetyloxy)-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-8-yl]methyl]piperidine-4-carboxylic acid |
| Rifampicin-019 | 4075-48-3 | (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-[(2,6-Dimethylpiperidin-1-yl)methyl]-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate |
| Rifampicin-020 | 4075-44-9 | (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-5,6,9,17,19-Pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-8-[(4-methylpiperazin-1-yl)methyl]-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate |
| Rifampicin-021 | 4075-41-6 | (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-[(Diethylamino)methyl]-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate |
| Rifampicin-022 | 4135-85-7 | (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-8-[(Dimethylamino)methyl]-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,11-dioxo-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-21-yl acetate |
优化Route 4步骤 4 · 总收率 14.02g(Rifampicin (FREE))
Rifampicin-01013553-79-2Rifampicin-01155686-22-1Rifampicin-02375-64-9Rifampicin-02494169-00-3Rifampicin-027—Rifampicin-025—Rifampicin-026—Rifampicin-0126928-85-4Rifampicin-028109-01-3API · 利福平
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Rifampicin-010 | 13553-79-2 | (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17-Trihydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23,27,29-tetraoxo-8,30-dioxa-24-azatetracyclo[23.3.1.1(4,7).0(5,28)]triaconta-1(28),2,4,9,19,21,25-heptaen-13-yl acetate |
| Rifampicin-011 | 55686-22-1 | N,N-Dihydroxymethyl-t-butylamine |
| Rifampicin-023 | 75-64-9在售 | 2-Methylpropan-2-amine |
| Rifampicin-024 | 94169-00-3 | (10S,13E,15S,16R,17S,18R,19R,20R,21S,22S,23E,25Z)-3-tert-Butyl-6,7,19,21-tetrahydroxy-15-methoxy-8,10,16,18,20,22,26-heptamethyl-11,27-dioxo-3,4,10,11-tetrahydro-2H-10,5-(epoxypentadeca[1,11,13]trienoimino)furo[2',3':7,8]naphtho[2,1-e][1,3]oxazin-17-yl acetate |
| Rifampicin-027 | - | (10S,13E,15S,16R,17S,18R,19R,20R,21S,22S,23E,25Z)-6,7,19,21-Tetrahydroxy-15-methoxy-3,8,10,16,18,20,22,26-octamethyl-11,27-dioxo-3,4,10,11-tetrahydro-2H-10,5-(epoxypentadeca[1,11,13]trienoimino)furo[2',3':7,8]naphtho[2,1-e][1,3]oxazin-17-yl acetate |
| Rifampicin-025 | - | (10S,13E,15S,16R,17S,18R,19R,20R,21S,22S,23E,25Z)-6,7,19,21-Tetrahydroxy-15-methoxy-8,10,16,18,20,22,26-heptamethyl-3-[2-(morpholin-4-yl)ethyl]-11,27-dioxo-3,4,10,11-tetrahydro-2H-10,5-(epoxypentadeca[1,11,13]trienoimino)furo[2',3':7,8]naphtho[2,1-e][1,3]oxazin-17-yl acetate |
| Rifampicin-026 | - | (10S,13E,15S,16R,17S,18R,19R,20R,21S,22S,23E,25Z)-3-(1-Ethylpiperidin-3-yl)-6,7,19,21-tetrahydroxy-15-methoxy-8,10,16,18,20,22,26-heptamethyl-11,27-dioxo-3,4,10,11-tetrahydro-2H-10,5-(epoxypentadeca[1,11,13]trienoimino)furo[2',3':7,8]naphtho[2,1-e][1,3]oxazin-17-yl acetate |
| Rifampicin-012 | 6928-85-4 | 4-Methylpiperazin-1-amine |
| Rifampicin-028 | 109-01-3在售 | N-Methylpiperazine |
优化Route 5步骤 2 · 总收率 /
Rifampicin-0296998-60-3,14897-39-3Rifampicin-01013553-79-2Rifampicin-03057375-25-4API · 利福平
| 编号 | CAS 号 | 中间体名称 |
|---|---|---|
| Rifampicin-029 | 6998-60-3,14897-39-3 | (2S,12Z,14E,16S,17S,18R,19R,20R,21S,22R,23S,24E)-21-Acetoxy-5,6,9,17,19-pentahydroxy-23-methoxy-2,4,12,16,18,20,22-heptamethyl-1,2-dihydro-2,7-(epoxypentadeca[1,11,13]trienoimino)naphtho[2,1-b]furan-1,11-dione |
| Rifampicin-010 | 13553-79-2 | (7S,9E,11S,12R,13S,14R,15R,16R,17S,18S,19E,21Z)-2,15,17-Trihydroxy-11-methoxy-3,7,12,14,16,18,22-heptamethyl-6,23,27,29-tetraoxo-8,30-dioxa-24-azatetracyclo[23.3.1.1(4,7).0(5,28)]triaconta-1(28),2,4,9,19,21,25-heptaen-13-yl acetate |
| Rifampicin-030 | 57375-25-4 | 3-Bromorifamycin S |
常见问题（FAQ）
利福平的适应症有哪些？
已批准的适应症包括：结核分枝杆菌感染、麻风分枝杆菌感染、肺结核、脑膜炎球菌性脑膜炎。
利福平的专利什么时候到期？
利福平的专利到期年暂无公开口径，本页会在数据管道核实后更新。
利福平有几条合成路线？
本站收录 5 条合成路线，最短路线 2 步、总收率 /。每条路线的中间体均带登记编号与 CAS 号。
利福平的关键中间体在哪里可以采购？
利福平的多条路线中间体已挂接 CAS 档案，其中 4 个 CAS 已有优贝德（Unibest）供应网络在售报价，可在本页路线表中直接查看并询价。
如何获取利福平中间体的报价？
在本页选择目标中间体的 CAS 进入档案页，或在询价页直接提交需求；CAS 会自动带入供需撮合流程，由供应网络反馈报价。
数据来源：多源数据交叉核实（仅结构化字段） · 2026-09-27