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CAS 1017234-25-1
3-[(1S)-1-[Methyl[(1S)-1-phenylethyl]amino]ethyl]phenyl ethyl(methyl)carbamate
登记编号：(VII)145089-9-a、(IX)145089-19-a
应用背景（按来源药适应症）
阿尔茨海默病重酒石酸卡巴拉汀痴呆重酒石酸卡巴拉汀帕金森病重酒石酸卡巴拉汀抗胆碱能综合征重酒石酸卡巴拉汀神经行为学表现重酒石酸卡巴拉汀认知障碍重酒石酸卡巴拉汀
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 重酒石酸卡巴拉汀Rivastigmine Tartrate | Tier B · 提前布局 | - |
合成路线中的位置（上下游链）
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(1S)-1-(3-Methoxyphenyl)-N-methyl-N-[(1S)-1-phenylethyl]ethanamine→(1S)-1-(3-Methoxyphenyl)-N-[(1S)-1-phenylethyl]ethanamine→(1S)-1-(3-Methoxyphenyl)-N,N-dimethyl-N-[(1S)-1-phenylethyl]ethanaminium iodide→(1S)-1-(3-Hydroxyphenyl)-N,N-dimethyl-N-[(1S)-1-phenylethyl]ethanaminium iodide→3-[(1S)-1-[Methyl[(1S)-1-phenylethyl]amino]ethyl]phenol→N-Ethyl-N-methylcarbamic chloride→(1S)-1-(3-[[Ethyl(methyl)carbamoyl]oxy]phenyl)-N,N-dimethyl-N-[(1S)-1-phenylethyl]ethanaminium iodide→3-[(1S)-1-[Methyl[(1S)-1-phenylethyl]amino]ethyl]phenyl ethyl(methyl)carbamate→(S)-3-(1-(Dimethylamino)ethyl)phenyl ethyl(methyl)carbamate
1-(3-Methoxyphenyl)ethanone→(S)-(-)-1-Phenylethylamine→(1S)-1-(3-Methoxyphenyl)-N-[(1S)-1-phenylethyl]ethanamine→(1S)-1-(3-Methoxyphenyl)-N-methyl-N-[(1S)-1-phenylethyl]ethanamine→3-[(1S)-1-[Methyl[(1S)-1-phenylethyl]amino]ethyl]phenol→N-Ethyl-N-methylcarbamic chloride→N-Ethyl-N-methylamine→Bis(trichloromethyl) carbonate→3-[(1S)-1-[Methyl[(1S)-1-phenylethyl]amino]ethyl]phenyl ethyl(methyl)carbamate→3-[(1S)-1-(Methylamino)ethyl]phenyl ethyl(methyl)carbamate→3-Acetylphenyl ethyl(methyl)carbamate→Aminomethane→(S)-3-(1-(Dimethylamino)ethyl)phenyl ethyl(methyl)carbamate→3-[(1E)-N-[(1S)-1-Phenylethyl]ethanimidoyl]phenyl ethyl(methyl)carbamate→3-[(1S)-1-[[(1S)-1-Phenylethyl]amino]ethyl]phenyl ethyl(methyl)carbamate
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