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CAS 107-22-2
EthanedialGlyoxal
登记编号：Tazobactam Sodium-013、Metronidazole hydrochloride-001
应用背景（按来源药适应症）
腹腔感染他唑巴坦钠/头孢洛生呼吸机相关性肺炎他唑巴坦钠/头孢洛生泌尿系统感染他唑巴坦钠/头孢洛生社区获得性细菌肺炎他唑巴坦钠/头孢洛生肾盂肾炎他唑巴坦钠/头孢洛生医院获得性肺炎他唑巴坦钠/头孢洛生十二指肠溃疡雷贝拉唑钠/甲硝唑/阿莫西林特发性血小板减少性紫癜雷贝拉唑钠/甲硝唑/阿莫西林胃溃疡雷贝拉唑钠/甲硝唑/阿莫西林胃炎雷贝拉唑钠/甲硝唑/阿莫西林幽门螺杆菌感染雷贝拉唑钠/甲硝唑/阿莫西林细菌感染头孢他啶/他唑巴坦钠呼吸道感染头孢他啶/他唑巴坦钠泌尿系统感染头孢他啶/他唑巴坦钠滴虫感染咪康唑/甲硝唑/利多卡因念珠菌病咪康唑/甲硝唑/利多卡因阴道炎咪康唑/甲硝唑/利多卡因
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 他唑巴坦钠/头孢洛生Tazobactam Sodium/Ceftolozane | Tier C · 观察 / 贸易 | - |
| 雷贝拉唑钠/甲硝唑/阿莫西林Rabeprazole Sodium/Metronidazole/Amoxicillin | Tier C · 观察 / 贸易 | - |
| 头孢他啶/他唑巴坦钠Ceftazidime/Tazobactam Sodium | Tier C · 观察 / 贸易 | - |
| 咪康唑/甲硝唑/利多卡因Miconazole/Metronidazole/Lidocaine | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(2S-(2alpha,3beta,5alpha))-3-(Chloromethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid diphenylmethyl ester→Benzhydryl (2S,3S,5R)-3-((1H-1,2,3-triazol-1-yl)methyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide→Ethanedial→Diamine→1,1'-(Ethane-1,2-diylidene)dihydrazine→1H-1,2,3-Triazol-1-amine→3-Amino-1-([(2S,3S,5R)-2-[(diphenylmethoxy)carbonyl]-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-3-yl]methyl)-1H-1,2,3-triazol-3-ium chloride→3-Amino-1-([(2S,3S,5R)-2-[(diphenylmethoxy)carbonyl]-3-methyl-4,4,7-trioxo-4lambda6-thia-1-azabicyclo[3.2.0]heptan-3-yl]methyl)-1H-1,2,3-triazol-3-ium chloride→2-Propynoic acid→(2S,3S,5R)-2-Methyl-2-(1H-1,2,3-triazol-1-ylmethyl)penam-3-carboxylic acid diphenylmethyl ester
Glyoxal→Ethanal→2-Methylglyoxaline→2-Methyl-4(5)-nitroimidazole→Ethylene chlorohydrin→Ethyl nitrile→Methyl ethanimidoate hydrochloride→2,2-Dimethoxyethanamine→N-(2,2-Dimethoxyethyl)ethanimidamide
(2S-(2alpha,3beta,5alpha))-3-(Chloromethyl)-3-methyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic acid diphenylmethyl ester→Benzhydryl (2S,3S,5R)-3-((1H-1,2,3-triazol-1-yl)methyl)-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate 4,4-dioxide→Ethanedial→Diamine→1,1'-(Ethane-1,2-diylidene)dihydrazine→1H-1,2,3-Triazol-1-amine→3-Amino-1-([(2S,3S,5R)-2-[(diphenylmethoxy)carbonyl]-3-methyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-3-yl]methyl)-1H-1,2,3-triazol-3-ium chloride→3-Amino-1-([(2S,3S,5R)-2-[(diphenylmethoxy)carbonyl]-3-methyl-4,4,7-trioxo-4lambda6-thia-1-azabicyclo[3.2.0]heptan-3-yl]methyl)-1H-1,2,3-triazol-3-ium chloride→2-Propynoic acid→(2S,3S,5R)-2-Methyl-2-(1H-1,2,3-triazol-1-ylmethyl)penam-3-carboxylic acid diphenylmethyl ester
Glyoxal→Ethanal→2-Methylglyoxaline→2-Methyl-4(5)-nitroimidazole→Ethylene chlorohydrin→Ethyl nitrile→Methyl ethanimidoate hydrochloride→2,2-Dimethoxyethanamine→N-(2,2-Dimethoxyethyl)ethanimidamide
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