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CAS 109-86-4
2-methoxyethan-1-ol
登记编号：Conteltinib-014
应用背景（按来源药适应症）
非小细胞肺癌康特替尼实体瘤康特替尼胰腺癌康特替尼
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 右旋糖酐/氯化钙/氯化钾/氯化钠/乳酸钠Dextran/Calcium Chloride/Potassium Chloride/Sodium Chloride/Sodium lactate | Tier C · 观察 / 贸易 | - |
| 康特替尼Conteltinib | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
6-aminopyrimidine-2,4(1H,3H)-dione→2-chloroacetaldehyde→7H-pyrrolo[2,3-d]pyrimidine-2,4-diol→6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-2,4-diol→2,4-dichloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine→2,4-dichloro-7-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine→tert-butyl 4-oxopiperidine-1-carboxylate→1-methylpiperazine→tert-butyl 4-(4-methylpiperazin-1-yl)piperidine-1-carboxylate→1-methyl-4-(piperidin-4-yl)piperazine→4-fluoro-2-methoxy-1-nitrobenzene→1-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine→2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline→2-methoxyethan-1-ol→4-chloro-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)-7-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-2-amine→2-amino-N-isopropylbenzenesulfonamide→N-isopropyl-2-((2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-7-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)benzenesulfonamide
6-aminopyrimidine-2,4(1H,3H)-dione→2-chloroacetaldehyde→7H-pyrrolo[2,3-d]pyrimidine-2,4-diol→6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine-2,4-diol→2,4-dichloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine→2,4-dichloro-7-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine→tert-butyl 4-oxopiperidine-1-carboxylate→1-methylpiperazine→tert-butyl 4-(4-methylpiperazin-1-yl)piperidine-1-carboxylate→1-methyl-4-(piperidin-4-yl)piperazine→4-fluoro-2-methoxy-1-nitrobenzene→1-(1-(3-methoxy-4-nitrophenyl)piperidin-4-yl)-4-methylpiperazine→2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)aniline→2-methoxyethan-1-ol→4-chloro-N-(2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)-7-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-2-amine→2-amino-N-isopropylbenzenesulfonamide→N-isopropyl-2-((2-((2-methoxy-4-(4-(4-methylpiperazin-1-yl)piperidin-1-yl)phenyl)amino)-7-(4-methoxybenzyl)-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidin-4-yl)amino)benzenesulfonamide
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