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CAS 110-16-7
maleic acid
登记编号：AVAT-011、AFAT-018
应用背景（按来源药适应症）
血小板减少马来酸阿伐曲泊帕特发性血小板减少性紫癜马来酸阿伐曲泊帕肝脏疾病马来酸阿伐曲泊帕非小细胞肺癌马来酸阿法替尼头颈部鳞状细胞癌马来酸阿法替尼头颈癌马来酸阿法替尼脊索瘤马来酸阿法替尼鳞状细胞癌马来酸阿法替尼胆囊癌马来酸阿法替尼
来源药（使用该中间体的合成路线）
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
1-(4-chlorothiophen-2-yl)ethanone→2-bromo-1-(4-chlorothiophen-2-yl)ethanone→thiourea→4-(4-chlorothiophen-2-yl)thiazol-2-amine→1-cyclohexylpiperazine→4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine→5,6-dichloronicotinic acid→5,6-dichloro-N-(4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)nicotinamide→ethyl piperidine-4-carboxylate→ethyl 1-(3-chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylate→maleic acid
3-chloro-4-fluoroaniline→(S)-tetrahydrofuran-3-ol→(S)-N-(3-chloro-4-fluorophenyl)-6-nitro-7-((tetrahydrofuran-3-yl)oxy)quinazolin-4-amine→(S)-N4-(3-chloro-4-fluorophenyl)-7-((tetrahydrofuran-3-yl)oxy)quinazoline-4,6-diamine→2-amino-4-chlorobenzoic acid→7-chloroquinazolin-4(3H)-one→7-chloro-6-nitroquinazolin-4(4aH)-one→4,7-dichloro-6-nitroquinazoline→N-(3-chloro-4-fluorophenyl)-6-nitro-7-(phenylsulfonyl)quinazolin-4-amine→2-(diethoxyphosphoryl)acetic acid→(S)-diethyl (2-((4-((3-chloro-4-fluorophenyl)amino)-7-((tetrahydrofuran-3-yl)oxy)quinazolin-6-yl)amino)-2-oxoethyl)phosphonate→2,2-diethoxy-N,N-dimethylethanamine→maleic acid
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 |
|---|---|---|---|---|---|
| Qualified Partner — East China API Works | 4-(4-chloro-2-thienyl)-2-ThiazolaMine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | 4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | 1-Cyclohexylpiperazine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | 5,6-Dichloronicotinic acid Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。