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CAS 132201-33-3
(2R,3S)-2-Hydroxy-3-phenyl-3-(phenylformamido)propanoic acid
登记编号：101438-23-a、(V)101438-37-a、(IV)101438-42-a、(VIII)101438-50-a、(IX)101438-66-a
应用背景（按来源药适应症）
乳腺癌Paclitaxel/Encequidar mesylate腺癌Paclitaxel/Encequidar mesylate血管肉瘤Paclitaxel/Encequidar mesylate实体瘤Paclitaxel/Encequidar mesylate
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| Paclitaxel/Encequidar mesylatePaclitaxel/Encequidar mesylate | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
methyl (2R,3R)-3-phenyloxirane-2-carboxylate→methyl 3-azido-2-hydroxy-3-phenylpropanoate→methyl 3-azido-2-oxo-3-phenylpropanoate→methyl (2R)-3-azido-2-hydroxy-3-phenylpropanoate→methyl (2R,3S)-3-azido-2-hydroxy-3-phenylpropanoate→(2R,3S)-2-Hydroxy-3-phenyl-3-(phenylformamido)propanoic acid
3-Phenyl-2-propenoic acid ethyl ester→ethyl (2R,3S)-2,3-dihydroxy-3-phenylpropanoate→ethyl (4S,5R)-3-benzoyl-2-oxo-4-phenyl-1,3-oxazolidine-5-carboxylate→(2R,3S)-3-Amino-2-hydroxy-3-phenylpropanoic acid→(2R,3S)-2-Hydroxy-3-phenyl-3-(phenylformamido)propanoic acid
methyl (2S,3R)-2,3-dihydroxy-3-phenylpropanoate→Benzonitrile→methyl (4S,5R)-2,4-diphenyl-4,5-dihydro-1,3-oxazole-5-carboxylate→(2R,3S)-2-Hydroxy-3-phenyl-3-(phenylformamido)propanoic acid
(±)-alpha-Aminophenylacetic acid→alpha-Chlorobenzaldehyde→2-Phenyl-2-(phenylformamido)acetic acid→1-(Chlorocarbonyl)formic acid ethyl ester→(1E)-3-Ethoxy-3-oxo-1-phenyl-1-[(phenylcarbonyl)amino]prop-1-en-2-yl ethyl ethanedioate→Ethyl 2-oxo-3-phenyl-3-[(phenylcarbonyl)amino]propanoate→(±)-Ethyl (2R,3S)-2-hydroxy-3-phenyl-3-[(phenylcarbonyl)amino]propanoate→(2R,3S)-2-Hydroxy-3-phenyl-3-(phenylformamido)propanoic acid
(1S,2S)-3-[[tert-Butyl(dimethyl)silyl]oxy]-1-phenylpropane-1,2-diol→2,2,2-Trichloroacetonitrile→(1S,2S)-3-[[tert-Butyl(dimethyl)silyl]oxy]-1-phenylpropane-1,2-diyl bis(2,2,2-trichloroethanimidate)→(4S,5R)-5-([[tert-Butyl(dimethyl)silyl]oxy]methyl)-4-phenyl-2-(trichloromethyl)-4,5-dihydro-1,3-oxazole→(2R,3S)-2-Hydroxy-3-phenyl-3-(phenylformamido)propanoic acid→N-((1S,2R)-3-TBDMSoxy-2-hydroxy-1-phenylpropyl)-2,2,2-trichloroacetamide→(2R,3S)-3-Amino-3-phenylpropane-1,2-diol→alpha-Chlorobenzaldehyde→N-[(1S,2R)-2,3-Dihydroxy-1-phenylpropyl]benzamide→(2R,3S)-3-Amino-2-hydroxy-3-phenylpropanoic acid→(2R,3S)-3-[(tert-Butoxycarbonyl)amino]-2-hydroxy-3-phenylpropanoic acid
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