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CAS 1612868-97-9

(4S,5S)-5-[(6S)-6-(3-Hydroxypropyl)-6-methylcyclohex-1-en-1-yl]-4-(3-methylbut-2-en-1-yl)-4-(2-methylpent-3-yn-2-yl)-1,3-dioxolan-2-one

登记编号:(XVII)101438-54-a

应用背景(按来源药适应症)

乳腺癌Paclitaxel/Encequidar mesylate腺癌Paclitaxel/Encequidar mesylate血管肉瘤Paclitaxel/Encequidar mesylate实体瘤Paclitaxel/Encequidar mesylate

来源药(使用该中间体的合成路线)

品种梯队到期年
Paclitaxel/Encequidar mesylatePaclitaxel/Encequidar mesylateTier C · 观察 / 贸易-

合成路线中的位置(上下游链)

按路线登记顺序排列,左→右为合成方向;高亮为当前 CAS,其余可点击跳转对应档案。

Paclitaxel/Encequidar mesylate优化路线步数:12总收率:/
2-Methylpropionic acid ethyl ester→2-Propynyl bromide→Ethyl 2,2-dimethylpent-4-ynoate→2,2-Dimethylpent-4-ynoic acid→1-Chloro-3-methyl-2-butene→2,2-Dimethylpent-3-ynoic acid→N-Methoxy-N-methylamine hydrochloride→N-Methoxy-N,2,2-trimethylpent-3-ynamide→chloro(3-methylbut-2-en-1-yl)magnesium→2,6,6-Trimethylnon-2-en-7-yn-5-one→Cyanotrimethylsilane→5-Methyl-2-(2-methylpent-3-yn-2-yl)-2-[(trimethylsilyl)oxy]hex-4-enenitrile→5-Methyl-2-(2-methylpent-3-yn-2-yl)-2-[(trimethylsilyl)oxy]hex-4-enal→(2E)-1-[1,1,1,3,3,3-Hexamethyl-2-(trimethylsilyl)trisilan-2-yl]-2-[(2S)-2-methyl-2-[3-(trityloxy)propyl]cyclohexylidene]hydrazine→(3aS,7Z,9aS,13bS)-6,9a,14,14-Tetramethyl-9,9a,10,11,12,13b-hexahydro-4H-3a,7-methanobenzo[3,4]cyclodeca[1,2-d][1,3]dioxol-2-one→(1S,2S)-5-Methyl-2-(2-methylpent-3-yn-2-yl)-1-[(6S)-6-methyl-6-[3-(trityloxy)propyl]cyclohex-1-en-1-yl]hex-4-ene-1,2-diol→(4S,5S)-4-(3-Methylbut-2-en-1-yl)-4-(2-methylpent-3-yn-2-yl)-5-[(6S)-6-methyl-6-[3-(trityloxy)propyl]cyclohex-1-en-1-yl]-1,3-dioxolan-2-one→(4S,5S)-5-[(6S)-6-(3-Hydroxypropyl)-6-methylcyclohex-1-en-1-yl]-4-(3-methylbut-2-en-1-yl)-4-(2-methylpent-3-yn-2-yl)-1,3-dioxolan-2-one→(4S)-5-[(6S)-6-Allyl-6-methylcyclohex-1-en-1-yl]-4-(3-methylbut-2-en-1-yl)-4-(2-methylpent-3-yn-2-yl)-1,3-dioxolan-2-one

本站可供应的对应中间体

目录暂未收录该靶点的在售中间体 —— 可直接发起询价,需求会进入撮合池。

本页为中间体 CAS 注册档案:同 CAS 的多条路线登记已合并;后续供应商报价与买方需求以该 CAS 为主键撮合。