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CAS 1782938-53-7
(4S,5S,7R)-4-[(1S,2S,3S,6S)-3-(Benzoyloxy)-2-(2-hydroxyethyl)-6-(methoxymethoxy)-2-methylcyclohexyl]-8,10,10-trimethyl-2-oxo-1,3-dioxaspiro[4.5]dec-8-en-7-yl benzoate
登记编号：(XXXII)101438-55-c
应用背景（按来源药适应症）
乳腺癌Paclitaxel/Encequidar mesylate腺癌Paclitaxel/Encequidar mesylate血管肉瘤Paclitaxel/Encequidar mesylate实体瘤Paclitaxel/Encequidar mesylate
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| Paclitaxel/Encequidar mesylatePaclitaxel/Encequidar mesylate | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(1S,2S,3S,4S)-2-(2-[[tert-Butyl(diphenyl)silyl]oxy]ethyl)-4-(methoxymethoxy)-2-methyl-3-[(4S,5S)-6,6,8-trimethyl-2,9-dioxo-1,3-dioxaspiro[4.5]dec-7-en-4-yl]cyclohexyl benzoate→(1S,2S,3S,4S)-2-(2-[[tert-Butyl(diphenyl)silyl]oxy]ethyl)-3-[(4S,5S,9R)-9-hydroxy-6,6,8-trimethyl-2-oxo-1,3-dioxaspiro[4.5]dec-7-en-4-yl]-4-(methoxymethoxy)-2-methylcyclohexyl benzoate→(4S,5S,7R)-4-[(1S,2S,3S,6S)-3-(Benzoyloxy)-2-(2-[[tert-butyl(diphenyl)silyl]oxy]ethyl)-6-(methoxymethoxy)-2-methylcyclohexyl]-8,10,10-trimethyl-2-oxo-1,3-dioxaspiro[4.5]dec-8-en-7-yl benzoate→(4S,5S,7R)-4-[(1S,2S,3S,6S)-3-(Benzoyloxy)-2-(2-hydroxyethyl)-6-(methoxymethoxy)-2-methylcyclohexyl]-8,10,10-trimethyl-2-oxo-1,3-dioxaspiro[4.5]dec-8-en-7-yl benzoate→(4S,5S)-4-[(1S,2S,3S,6S)-3-(Benzoyloxy)-6-(methoxymethoxy)-2-methyl-2-(2-oxoethyl)cyclohexyl]-8,10,10-trimethyl-2-oxo-1,3-dioxaspiro[4.5]dec-8-en-7-yl benzoate→(3aS,7S,8R,9aS,10S,13S,13aS,13bS)-8-Hydroxy-13-(methoxymethoxy)-6,9a,14,14-tetramethyl-2-oxo-7,8,9,9a,10,11,12,13,13a,13b-decahydro-4H-3a,7-methanobenzo[3,4]cyclodeca[1,2-d][1,3]dioxol-10-yl benzoate
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