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CAS 192704-54-4
(2R,5'S,7'R,10'R,11'R,13'S)-11'-hydroxy-10',13'-dimethyl-3',5,18'-trioxohexadecahydro-3H-spiro[furan-2,17'-[4,7]methanocyclopenta[a]phenanthrene]-5'(2'H)-carbonitrile
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应用背景（按来源药适应症）
高血压依普利酮心脏衰竭依普利酮醛固酮增多症依普利酮心肌梗塞依普利酮慢性肾功能不全依普利酮原发性高血压依普利酮
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 依普利酮Eplerenone | Tier C · 观察 / 贸易 | - |
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按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(10R,11R,13S,17R)-11-hydroxy-10,13-dimethyl-1,3',4',8,9,10,11,12,13,14,15,16-dodecahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H)-dione→2-hydroxy-2-methylpropanenitrile→(2R,5'R,7'R,10'R,11'R,13'S)-18'-amino-11'-hydroxy-10',13'-dimethyl-3',5-dioxo-1',2',3',4,5,6',7',8',9',10',11',12',13',14',15',16'-hexadecahydro-3H,5'H-spiro[furan-2,17'-[4,7](metheno)cyclopenta[a]phenanthrene]-5'-carbonitrile→(2R,5'S,7'R,10'R,11'R,13'S)-11'-hydroxy-10',13'-dimethyl-3',5,18'-trioxohexadecahydro-3H-spiro[furan-2,17'-[4,7]methanocyclopenta[a]phenanthrene]-5'(2'H)-carbonitrile→methyl (7R,10R,11R,13S,17R)-11-hydroxy-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-carboxylate→methyl (7R,10R,11R,13S,17R)-10,13-dimethyl-11-((methylsulfonyl)oxy)-3,5'-dioxo-1,2,3,4',5',6,7,8,9,10,11,12,13,14,15,16-hexadecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-carboxylate→methyl (7R,10S,13S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,10,12,13,14,15,16-tetradecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-carboxylate
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