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CAS 2044680-91-1
(1aR,1bS,2aS,3aS,6aS,10S,10aS,11aS)-10-[(Benzyloxy)methoxy]-1b,10a,12,12-tetramethyl-2a,3,8,9,10,10a,11,11a-octahydro-1bH,5H,6aH-1a,3a-methanobenzo[3,4]bisoxireno[6,7:8,9]cyclodeca[1,2-d][1,3]dioxol-5-one
登记编号：(XVIII)101438-60-b
应用背景（按来源药适应症）
乳腺癌Paclitaxel/Encequidar mesylate腺癌Paclitaxel/Encequidar mesylate血管肉瘤Paclitaxel/Encequidar mesylate实体瘤Paclitaxel/Encequidar mesylate
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| Paclitaxel/Encequidar mesylatePaclitaxel/Encequidar mesylate | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
Lithiumbenzene→(4S,5S)-5-[(5S,6S)-5-[(Benzyloxy)methoxy]-6-methyl-6-(prop-2-en-1-yl)cyclohex-1-en-1-yl]-4-(3-methylbut-2-en-1-yl)-4-(2-methylpent-3-yn-2-yl)-1,3-dioxolan-2-one→(3aS,7Z,9aS,10S,13bS)-10-[(Benzyloxy)methoxy]-6,9a,14,14-tetramethyl-9,9a,10,11,12,13b-hexahydro-2H,4H-3a,7-methanobenzo[3,4]cyclodeca[1,2-d][1,3]dioxol-2-one→(1aR,1bS,2aS,3aS,6aS,10S,10aS,11aS)-10-[(Benzyloxy)methoxy]-1b,10a,12,12-tetramethyl-2a,3,8,9,10,10a,11,11a-octahydro-1bH,5H,6aH-1a,3a-methanobenzo[3,4]bisoxireno[6,7:8,9]cyclodeca[1,2-d][1,3]dioxol-5-one→(1aR,2S,3S,5S,6S,10S,10aS,11aS)-10-[(Benzyloxy)methoxy]-5-hydroxy-2,10a,12,12-tetramethyl-3,4,5,6,8,9,10,10a,11,11a-decahydro-2H-2,3-epoxy-1a,5-methanobenzo[4,5]cyclodeca[1,2-b]oxiren-6-yl benzoate→(1S,5S,6S,8S,11S,12aS)-1-[(Benzyloxy)methoxy]-6,8,11-trihydroxy-9,12a,13,13-tetramethyl-1,2,3,5,6,7,8,11,12,12a-decahydro-6,10-methanobenzo[10]annulen-5-yl benzoate→(1S,5S,6S,8S,11S,12aS)-1-[(Benzyloxy)methoxy]-6,8-dihydroxy-9,12a,13,13-tetramethyl-11-[(triethylsilyl)oxy]-1,2,3,5,6,7,8,11,12,12a-decahydro-6,10-methanobenzo[10]annulen-5-yl benzoate
本站可供应的对应中间体
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