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CAS 2401852-78-4
N-[(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-23-[(4S,5S)-2-(3,4-Dimethoxyphenyl)-5-(4-hydroxyphenyl)-1,3,2-dioxaborolan-4-yl]-2,11,12,15-tetrahydroxy-6,20-bis[(1R)-1-hydroxyethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl]-3(4)-(pentyloxy)[1(1),2(1):2(4),3(1)-terphenyl]-1(4)-carboxamide
登记编号：(XXVc)796686-1-d
应用背景（按来源药适应症）
侵袭性念珠菌病醋酸瑞扎芬净念珠菌病醋酸瑞扎芬净念珠菌血症醋酸瑞扎芬净卡氏肺囊虫感染醋酸瑞扎芬净侵袭性真菌感染醋酸瑞扎芬净曲霉菌属感染醋酸瑞扎芬净
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 醋酸瑞扎芬净Rezafungin acetate | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-6,20-Bis[(1R)-1-(acetyloxy)ethyl]-9-amino-23-[(1S,2S)-1,2-bis(acetyloxy)-2-[4-(acetyloxy)phenyl]ethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosine-2,11,12,15-tetrayl tetraacetate→4''-(Pentyloxy)-1,1':4',1''-terphenyl-4-carboxylic acid→(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-6,20-Bis[(1R)-1-(acetyloxy)ethyl]-23-[(1S,2S)-1,2-bis(acetyloxy)-2-[4-(acetyloxy)phenyl]ethyl]-16-methyl-5,8,14,19,22,25-hexaoxo-9-[[3(4)-(pentyloxy)[1(1),2(1):2(4),3(1)-terphenyl]-1(4)-carbonyl]amino]tetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosine-2,11,12,15-tetrayl tetraacetate→(11aS,25aS)-N-[9(S)-[1(S),2(S)-Dihydroxy-2-(4-hydroxyphenyl)ethyl]-1(S),13(R),22(R),23(R)-tetrahydroxy-6(S),17(S)-bis[1(R)-hydroxyethyl]-2(S)-methyl-5,8,11,16,19,25-hexaoxoperhydrodipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacycloheneicosin-20(S)-yl]-4''-pentyloxy-p-terphenyl-4-carboxamide→N-[(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-23-[(4S,5S)-2-(3,4-Dimethoxyphenyl)-5-(4-hydroxyphenyl)-1,3,2-dioxaborolan-4-yl]-2,11,12,15-tetrahydroxy-6,20-bis[(1R)-1-hydroxyethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl]-3(4)-(pentyloxy)[1(1),2(1):2(4),3(1)-terphenyl]-1(4)-carboxamide
(11aS,25aS)-N-[9(S)-[1(S),2(S)-Dihydroxy-2-(4-hydroxyphenyl)ethyl]-1(S),13(R),22(R),23(R)-tetrahydroxy-6(S),17(S)-bis[1(R)-hydroxyethyl]-2(S)-methyl-5,8,11,16,19,25-hexaoxoperhydrodipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacycloheneicosin-20(S)-yl]-4''-pentyloxy-p-terphenyl-4-carboxamide→Methyl iodide→3(4)-(Pentyloxy)-N-[(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-2,11,12,15-tetrahydroxy-6,20-bis[(1R)-1-hydroxyethyl]-23-[(4S,5S)-5-(4-hydroxyphenyl)-2-phenyl-1,3,2-dioxaborolan-4-yl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl][1(1),2(1):2(4),3(1)-terphenyl]-1(4)-carboxamide→3(4)-(Pentyloxy)-N-[(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-2,11,12,15-tetrahydroxy-6,20-bis[(1R)-1-hydroxyethyl]-23-[(4S,5S)-5-(4-hydroxyphenyl)-2-[4-(trifluoromethyl)phenyl]-1,3,2-dioxaborolan-4-yl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl][1(1),2(1):2(4),3(1)-terphenyl]-1(4)-carboxamide→N-[(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-23-[(4S,5S)-2-(3,4-Dimethoxyphenyl)-5-(4-hydroxyphenyl)-1,3,2-dioxaborolan-4-yl]-2,11,12,15-tetrahydroxy-6,20-bis[(1R)-1-hydroxyethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl]-3(4)-(pentyloxy)[1(1),2(1):2(4),3(1)-terphenyl]-1(4)-carboxamide→N-[(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-23-[(4S,5S)-2-(2,6-Dimethylphenyl)-5-(4-hydroxyphenyl)-1,3,2-dioxaborolan-4-yl]-2,11,12,15-tetrahydroxy-6,20-bis[(1R)-1-hydroxyethyl]-16-methyl-5,8,14,19,22,25-hexaoxotetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-9-yl]-3(4)-(pentyloxy)[1(1),2(1):2(4),3(1)-terphenyl]-1(4)-carboxamide→2-Hydroxy-N,N,N-trimethylethylammonium chloride→2-[[(2R,6S,9S,11R,12R,14aS,15S,16S,20S,23S,25aS)-23-[(1S,2S)-1,2-Dihydroxy-2-(4-hydroxyphenyl)ethyl]-2,11,15-trihydroxy-6,20-bis[(1R)-1-hydroxyethyl]-16-methyl-5,8,14,19,22,25-hexaoxo-9-[[3(4)-(pentyloxy)[1(1),2(1):2(4),3(1)-terphenyl]-1(4)-carbonyl]amino]tetracosahydro-1H-dipyrrolo[2,1-c:2',1'-l][1,4,7,10,13,16]hexaazacyclohenicosin-12-yl]oxy]-N,N,N-trimethylethan-1-aminium→2-(Dimethylamino)ethanol hydrochloride
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