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CAS 2730018-03-6
(3aS,8S,9S,9aR,10S,13bS)-10-(Benzyloxy)-9-hydroxy-6,9a,13,14,14-pentamethyl-2-oxo-5,8,9,9a,10,11,12,13b-octahydro-2H,4H-3a,7-methanobenzo[3,4]cyclodeca[1,2-d][1,3]dioxol-8-yl acetate
登记编号：(XVI)101438-71-b
应用背景（按来源药适应症）
乳腺癌Paclitaxel/Encequidar mesylate腺癌Paclitaxel/Encequidar mesylate血管肉瘤Paclitaxel/Encequidar mesylate实体瘤Paclitaxel/Encequidar mesylate
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| Paclitaxel/Encequidar mesylatePaclitaxel/Encequidar mesylate | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(1S,5S,10S,11S,12S,16S)-10-(Benzyloxy)-7,11,14,14,18,21,21-heptamethyl-2,4,13,15-tetraoxapentacyclo[15.3.1.0(1,5).0(6,11).0(12,16)]henicosa-6,17-dien-3-one→(3aS,5S,8R,9aS,10S,13bS)-5-Hydroxy-6,9a,13,14,14-pentamethyl-12-[2-(4-methylbenzene-1-sulfonyl)hydrazinylidene]-2,9-dioxo-10-[(triethylsilyl)oxy]-5,8,9,9a,10,11,12,13b-octahydro-2H,4H-3a,7-methanobenzo[3,4]cyclodeca[1,2-d][1,3]dioxol-8-yl acetate→(3aS,5S,8R,9aS,10S,13bS)-6,9a,13,14,14-Pentamethyl-12-[2-(4-methylbenzene-1-sulfonyl)hydrazinylidene]-2,9-dioxo-10-[(triethylsilyl)oxy]-5-[(trimethylsilyl)oxy]-5,8,9,9a,10,11,12,13b-octahydro-2H,4H-3a,7-methanobenzo[3,4]cyclodeca[1,2-d][1,3]dioxol-8-yl acetate→(3aS,8R,9aS,10S,13bS)-10-(Benzyloxy)-6,9a,13,14,14-pentamethyl-2,9-dioxo-5,8,9,9a,10,11,12,13b-octahydro-2H,4H-3a,7-methanobenzo[3,4]cyclodeca[1,2-d][1,3]dioxol-8-yl acetate→(3aS,8R,9aS,10S,13bS)-6,9a,13,14,14-Pentamethyl-2,5,9,12-tetraoxo-10-[(triethylsilyl)oxy]-5,8,9,9a,10,11,12,13b-octahydro-2H,4H-3a,7-methanobenzo[3,4]cyclodeca[1,2-d][1,3]dioxol-8-yl acetate→(3aS,8R,9aS,10S,13bS)-6,9a,13,14,14-Pentamethyl-2,9-dioxo-10-[(triethylsilyl)oxy]-5,8,9,9a,10,11,12,13b-octahydro-2H,4H-3a,7-methanobenzo[3,4]cyclodeca[1,2-d][1,3]dioxol-8-yl acetate→(3aS,8S,9S,9aR,10S,13bS)-10-(Benzyloxy)-8,9-dihydroxy-6,9a,13,14,14-pentamethyl-5,8,9,9a,10,11,12,13b-octahydro-2H,4H-3a,7-methanobenzo[3,4]cyclodeca[1,2-d][1,3]dioxol-2-one→(3aS,8S,9S,9aR,10S,13bS)-10-(Benzyloxy)-9-hydroxy-6,9a,13,14,14-pentamethyl-2-oxo-5,8,9,9a,10,11,12,13b-octahydro-2H,4H-3a,7-methanobenzo[3,4]cyclodeca[1,2-d][1,3]dioxol-8-yl acetate→4-Methylbenzenesulfonhydrazide→Acetic acid acetic anhydride
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