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CAS 3272-08-0
4-hydroxy-3-nitrobenzonitrile
登记编号：AFAT-028、FEBU-002
应用背景（按来源药适应症）
非小细胞肺癌马来酸阿法替尼头颈部鳞状细胞癌马来酸阿法替尼头颈癌马来酸阿法替尼脊索瘤马来酸阿法替尼鳞状细胞癌马来酸阿法替尼胆囊癌马来酸阿法替尼高尿酸血症非布司他痛风非布司他颅内出血非布司他溃疡性结肠炎非布司他慢性肾功能不全非布司他疼痛非布司他
来源药（使用该中间体的合成路线）
合成路线中的位置（上下游链）
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3-chloro-4-fluoroaniline→(S)-tetrahydrofuran-3-ol→(E)-4-(dimethylamino)but-2-enoyl chloride→4-hydroxybenzonitrile→4-hydroxy-3-nitrobenzonitrile→(S)-3-nitro-4-((tetrahydrofuran-3-yl)oxy)benzonitrile→(S)-3-amino-4-((tetrahydrofuran-3-yl)oxy)benzonitrile→(S,E)-N-(5-cyano-2-((tetrahydrofuran-3-yl)oxy)phenyl)-4-(dimethylamino)but-2-enamide→(S,E)-N-(5-cyano-4-nitro-2-((tetrahydrofuran-3-yl)oxy)phenyl)-4-(dimethylamino)but-2-enamide→(S,E)-N-(4-amino-5-cyano-2-((tetrahydrofuran-3-yl)oxy)phenyl)-4-(dimethylamino)but-2-enamide→(E)-N-(5-cyano-4-((E)-((dimethylamino)methylene)amino)-2-(((S)-tetrahydrofuran-3-yl)oxy)phenyl)-4-(dimethylamino)but-2-enamide
4-hydroxy-3-nitrobenzaldehyde→4-hydroxy-3-nitrobenzonitrile→4-hydroxy-3-nitrobenzothioamide→ethyl 2-chloro-3-oxobutanoate→ethyl 2-(4-hydroxy-3-nitrophenyl)-4-methylthiazole-5-carboxylate→1-bromo-2-methylpropane→ethyl 2-(4-isobutoxy-3-nitrophenyl)-4-methylthiazole-5-carboxylate→ethyl 2-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-5-carboxylate
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| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 |
|---|---|---|---|---|---|
| Qualified Partner — East China API Works | Ethyl 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | Ethyl 2-(4-hydroxyphenyl)-4-methylthiazole-5-carboxylate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。