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CAS 4242-00-6
(4aS,5S)-5-Hydroxy-4a-methyl-4,4a,5,6,7,8-hexahydronaphthalen-2(3H)-one
登记编号：(II)101438-60-a
应用背景（按来源药适应症）
乳腺癌Paclitaxel/Encequidar mesylate腺癌Paclitaxel/Encequidar mesylate血管肉瘤Paclitaxel/Encequidar mesylate实体瘤Paclitaxel/Encequidar mesylate
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| Paclitaxel/Encequidar mesylatePaclitaxel/Encequidar mesylate | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(S)-(+)-3,4,8,8a-Tetrahydro-8a-methyl-1,6(2H,7H)-naphthalenedione→(4aS,5S)-5-Hydroxy-4a-methyl-4,4a,5,6,7,8-hexahydronaphthalen-2(3H)-one→(4aS,5S)-4a-Methyl-5-[(triethylsilyl)oxy]-4,4a,5,6,7,8-hexahydronaphthalen-2(3H)-one→3-[(1R,6S)-1-Methyl-2-oxo-6-[(triethylsilyl)oxy]cyclohexyl]propanoic acid→N'-[(2S,4aS,8aS)-2-Methoxy-4a-methyloctahydro-5H-1-benzopyran-5-ylidene]-2,4,6-tri(propan-2-yl)benzene-1-sulfonohydrazide→S-Ethyl 3-[(1R,6S)-1-methyl-2-oxo-6-[(triethylsilyl)oxy]cyclohexyl]propanethioate→(2S,4aR,8aS)-2-Hydroxy-4a-methyloctahydro-5H-1-benzopyran-5-one→(2S,4aR,8aS)-2-Methoxy-4a-methyloctahydro-5H-1-benzopyran-5-one→2,4,6-Triisopropylbenzenesulfonohydrazide→5-Methyl-2-(2-methylpent-3-yn-2-yl)-2-[(trimethylsilyl)oxy]hex-4-enal→(1S,2S)-1-[(2S,4aS,8aS)-2-Methoxy-4a-methyl-3,4,4a,7,8,8a-hexahydro-2H-1-benzopyran-5-yl]-5-methyl-2-(2-methylpent-3-yn-2-yl)hex-4-ene-1,2-diol→(4S,5S)-5-[(2S,4aS,8aS)-2-Methoxy-4a-methyl-3,4,4a,7,8,8a-hexahydro-2H-1-benzopyran-5-yl]-4-(3-methylbut-2-en-1-yl)-4-(2-methylpent-3-yn-2-yl)-1,3-dioxolan-2-one→(4S,5S)-5-[(4aS,8aS)-2-Hydroxy-4a-methyl-3,4,4a,7,8,8a-hexahydro-2H-1-benzopyran-5-yl]-4-(3-methylbut-2-en-1-yl)-4-(2-methylpent-3-yn-2-yl)-1,3-dioxolan-2-one→(4S,5S)-5-[(5S,6S)-5-Hydroxy-6-(3-hydroxypropyl)-6-methylcyclohex-1-en-1-yl]-4-(3-methylbut-2-en-1-yl)-4-(2-methylpent-3-yn-2-yl)-1,3-dioxolan-2-one→(4S,5S)-5-[(5S,6S)-5-Hydroxy-6-methyl-6-(prop-2-en-1-yl)cyclohex-1-en-1-yl]-4-(3-methylbut-2-en-1-yl)-4-(2-methylpent-3-yn-2-yl)-1,3-dioxolan-2-one→(4S,5S)-5-[(5S,6S)-5-[(Benzyloxy)methoxy]-6-methyl-6-(prop-2-en-1-yl)cyclohex-1-en-1-yl]-4-(3-methylbut-2-en-1-yl)-4-(2-methylpent-3-yn-2-yl)-1,3-dioxolan-2-one
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