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CAS 4318-56-3
6-chloro-3-methylpyrimidine-2,4(1H,3H)-dione
登记编号：TREL-004、ALOG-021
应用背景（按来源药适应症）
二型糖尿病琥珀酸曲格列汀糖尿病琥珀酸曲格列汀二型糖尿病苯甲酸阿格列汀糖尿病苯甲酸阿格列汀急性冠脉综合征苯甲酸阿格列汀
来源药（使用该中间体的合成路线）
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
1-bromo-4-fluoro-2-methylbenzene→4-fluoro-2-methylbenzonitrile→2-(bromomethyl)-4-fluorobenzonitrile→6-chloro-3-methylpyrimidine-2,4(1H,3H)-dione→2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile→(R)-piperidin-3-amine→succinic acid→(R)-2,5-diaminopentanoic acid hydrochloride→(R)-methyl 2,5-diaminopentanoate→(R)-3-aminopiperidin-2-one hydrochloride→(R)-piperidin-3-amine
2-(bromomethyl)-4-fluorobenzonitrile→6-chloro-3-methylpyrimidine-2,4(1H,3H)-dione→2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile→(R)-piperidin-3-amine→(R)-2-(piperidin-3-yl)isoindoline-1,3-dione→(R)-2-((6-(3-(1,3-dioxoisoindolin-2-yl)piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)-4-fluorobenzonitrile→isobenzofuran-1,3-dione
6-chloro-3-methylpyrimidine-2,4(1H,3H)-dione→(R)-tert-butyl (1-(3,5-dimethyl-2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-7-yl)piperidin-3-yl)carbamate→2-((6-chloro-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile→(R)-2-(piperidin-3-yl)isoindoline-1,3-dione→(R)-2-((6-(3-(1,3-dioxoisoindolin-2-yl)piperidin-1-yl)-3-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile→(R)-piperidin-3-amine dihydrochloride→isobenzofuran-1,3-dione
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| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 |
|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 6-Chloro-3-methyluracil Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。