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CAS 480450-71-3
N-((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide
登记编号：EDOX-013
应用背景（按来源药适应症）
肺栓塞甲苯磺酸艾多沙班静脉血栓栓塞甲苯磺酸艾多沙班中风甲苯磺酸艾多沙班栓塞甲苯磺酸艾多沙班静脉血栓形成甲苯磺酸艾多沙班缺血性卒中甲苯磺酸艾多沙班
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 甲苯磺酸艾多沙班Edoxaban Tosilate Hydrate | Tier B · 提前布局 | 2028 |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
cyclohex-3-ene-1-carboxylic acid→(S)-cyclohex-3-ene-1-carboxylic acid→(1S,4S,5S)-4-iodo-6-oxabicyclo[3.2.1]octan-7-one→ethyl (1S,3S,6R)-7-oxabicyclo[4.1.0]heptane-3-carboxylate→ethyl (1S,3R,4R)-3-azido-4-hydroxycyclohexane-1-carboxylate→ethyl (1S,3R,4R)-3-((tert-butoxycarbonyl)amino)-4-hydroxycyclohexane-1-carboxylate→ethyl (1S,3R,4S)-4-azido-3-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylate→(1S,3R,4S)-4-azido-3-((tert-butoxycarbonyl)amino)cyclohexane-1-carboxylic acid→tert-butyl ((1R,2S,5S)-2-azido-5-(dimethylcarbamoyl)cyclohexyl)carbamate→(1S,3R,4S)-3-amino-4-azido-N,N-dimethylcyclohexane-1-carboxamide→lithium 5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylate→N-((1R,2S,5S)-2-azido-5-(dimethylcarbamoyl)cyclohexyl)-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide→N-((1R,2S,5S)-2-amino-5-(dimethylcarbamoyl)cyclohexyl)-5-methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxamide→sodium 2-((5-chloropyridin-2-yl)amino)-2-oxoacetate
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