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CAS 610785-45-0
(1'R,2R,3a'R,7a'R,9a'S,12a'S,12b'R)-7a',9a'-dimethyl-1',3,4,6',7',7a',9',9a',11',12',12a',12b'-dodecahydro-2'H,5H-spiro[furan-2,10'-[1,3a]methanobenzo[b]indeno[5,4-d]oxepine]-2',5,5'(4'H)-trione
登记编号：EPLE-017
应用背景（按来源药适应症）
高血压依普利酮心脏衰竭依普利酮醛固酮增多症依普利酮心肌梗塞依普利酮慢性肾功能不全依普利酮原发性高血压依普利酮
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 依普利酮Eplerenone | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
methyl (7R,10S,13S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,10,12,13,14,15,16-tetradecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-carboxylate→(10R,13S,17R)-10,13-dimethyl-1,3',4',8,10,12,13,14,15,16-decahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H)-dione→(7R,10S,13S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',6,7,8,10,12,13,14,15,16-tetradecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-7-carboxylic acid→2-methylfuran→(7R,8R,10S,13S,14S,17R)-10,13-dimethyl-7-(5-methylfuran-2-yl)-1,3',4',6,7,8,10,12,13,14,15,16-dodecahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H)-dione→2-methyl-1-(vinyloxy)propane→(7R,8R,10S,13S,14S,17R)-10,13-dimethyl-7-((E)-4-oxopent-2-enoyl)-1,3',4',6,7,8,10,12,13,14,15,16-dodecahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H)-dione→(7R,8R,10S,13S,14S,17R)-7-(2-hydroxy-2-methoxyacetyl)-10,13-dimethyl-1,3',4',6,7,8,10,12,13,14,15,16-dodecahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H)-dione→(1'R,2R,3a'R,7a'R,9a'S,12a'S,12b'R)-7a',9a'-dimethyl-1',3,4,6',7',7a',9',9a',11',12',12a',12b'-dodecahydro-2'H,5H-spiro[furan-2,10'-[1,3a]methanobenzo[b]indeno[5,4-d]oxepine]-2',5,5'(4'H)-trione
(10R,11R,13S,17R)-11-hydroxy-10,13-dimethyl-1,3',4',8,9,10,11,12,13,14,15,16-dodecahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H)-dione→(10R,13S,17R)-10,13-dimethyl-1,3',4',8,10,12,13,14,15,16-decahydro-5'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-3,5'(2H)-dione→(1'R,2R,3a'R,7a'R,9a'S,12a'S,12b'R)-7a',9a'-dimethyl-1',3,4,6',7',7a',9',9a',11',12',12a',12b'-dodecahydro-2'H,5H-spiro[furan-2,10'-[1,3a]methanobenzo[b]indeno[5,4-d]oxepine]-2',5,5'(4'H)-trione→(10R,11R,13S,17R)-10,13-dimethyl-3,5'-dioxo-1,2,3,4',5',8,9,10,11,12,13,14,15,16-tetradecahydro-3'H-spiro[cyclopenta[a]phenanthrene-17,2'-furan]-11-yl methanesulfonate→(1'R,2R,3a'R,7a'R,9a'S)-7a',9a'-dimethyl-1',3,4,6',7',7a',9',9a',11',12',12a',12b'-dodecahydro-2'H,5H-spiro[furan-2,10'-[1,3a]methanobenzo[b]indeno[5,4-d]oxepine]-5,5'(4'H)-dione→3-methyl-3-(trifluoromethyl)dioxirane→(1'R,2R,2'S,3a'R,7a'R,9a'S)-2'-hydroxy-7a',9a'-dimethyl-1',3,4,6',7',7a',9',9a',11',12',12a',12b'-dodecahydro-2'H,5H-spiro[furan-2,10'-[1,3a]methanobenzo[b]indeno[5,4-d]oxepine]-5,5'(4'H)-dione
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