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CAS 63-91-2
L-phenylalanine
登记编号：RITO-027
应用背景（按来源药适应症）
慢性丙型肝炎帕利普韦/奥比他韦/利托那韦丙型肝炎帕利普韦/奥比他韦/利托那韦失代偿性肝硬化帕利普韦/奥比他韦/利托那韦肾功能不全帕利普韦/奥比他韦/利托那韦纤维化帕利普韦/奥比他韦/利托那韦终末期肾脏病帕利普韦/奥比他韦/利托那韦HIV感染乙醇达芦那韦/利托那韦
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 帕利普韦/奥比他韦/利托那韦Paritaprevir/Ombitasvir/Ritonavir | Tier C · 观察 / 贸易 | - |
| 乙醇达芦那韦/利托那韦Darunavir Ethanolate/Ritonavir | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
4-nitrophenyl (thiazol-5-ylmethyl) carbonate→thiazol-5-ylmethyl ((2S,3S,5S)-5-amino-3-hydroxy-1,6-diphenylhexan-2-yl)carbamate→(S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid→L-phenylalanine→(S)-benzyl 2-(dibenzylamino)-3-phenylpropanoate→benzylmagnesium chloride→(S,E)-5-amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one→(2S,3S,5S)-5-amino-2-(dibenzylamino)-1,6-diphenylhexan-3-ol→tert-butyl ((2S,4S,5S)-5-(dibenzylamino)-4-hydroxy-1,6-diphenylhexan-2-yl)carbamate→tert-butyl ((2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl)carbamate succinate
L-phenylalanine→tert-butyl ((2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl)carbamate succinate→(S)-2-amino-3-phenylpropan-1-ol→(S)-1-chloro-3-phenylpropan-2-amine→(S)-tert-butyl (1-chloro-3-phenylpropan-2-yl)carbamate→(S)-tert-butyl (1-cyano-3-phenylpropan-2-yl)carbamate→(S)-tert-butyl (1-oxo-3-phenylpropan-2-yl)carbamate→(2-nitroethyl)benzene→tert-butyl ((2S,4S,5S)-4-hydroxy-5-nitro-1,6-diphenylhexan-2-yl)carbamate→tert-butyl ((2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl)carbamate
4-nitrophenyl (thiazol-5-ylmethyl) carbonate→thiazol-5-ylmethyl ((2S,3S,5S)-5-amino-3-hydroxy-1,6-diphenylhexan-2-yl)carbamate→(S)-2-(3-((2-isopropylthiazol-4-yl)methyl)-3-methylureido)-3-methylbutanoic acid→L-phenylalanine→(S)-benzyl 2-(dibenzylamino)-3-phenylpropanoate→benzylmagnesium chloride→(S,E)-5-amino-2-(dibenzylamino)-1,6-diphenylhex-4-en-3-one→(2S,3S,5S)-5-amino-2-(dibenzylamino)-1,6-diphenylhexan-3-ol→tert-butyl ((2S,4S,5S)-5-(dibenzylamino)-4-hydroxy-1,6-diphenylhexan-2-yl)carbamate→tert-butyl ((2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl)carbamate succinate
L-phenylalanine→tert-butyl ((2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl)carbamate succinate→(S)-2-amino-3-phenylpropan-1-ol→(S)-1-chloro-3-phenylpropan-2-amine→(S)-tert-butyl (1-chloro-3-phenylpropan-2-yl)carbamate→(S)-tert-butyl (1-cyano-3-phenylpropan-2-yl)carbamate→(S)-tert-butyl (1-oxo-3-phenylpropan-2-yl)carbamate→(2-nitroethyl)benzene→tert-butyl ((2S,4S,5S)-4-hydroxy-5-nitro-1,6-diphenylhexan-2-yl)carbamate→tert-butyl ((2S,4S,5S)-5-amino-4-hydroxy-1,6-diphenylhexan-2-yl)carbamate
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