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CAS 71989-16-7
N2-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-asparagine
登记编号：Atosiban-142
应用背景（按来源药适应症）
产科分娩（早产）阿托西班醋酸盐早产（孕37周前）阿托西班醋酸盐子宫内膜异位症阿托西班醋酸盐
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 阿托西班醋酸盐Atosiban acetate | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
1-[[(9H-Fluoren-9-yl)methoxy]carbonyl]-L-prolyl-N5-(tert-butoxycarbonyl)-L-ornithine→Glycinamide→Resin bound S-(triphenylmethyl)-L-cysteinyl-L-prolyl-L-ornithylglycinamide→1-[[(9H-Fluoren-9-yl)methoxy]carbonyl]-L-prolyl-N5-(tert-butoxycarbonyl)-L-ornithylglycinamide→1-[[(9H-Fluoren-9-yl)methoxy]carbonyl]-L-prolyl-L-ornithylglycinamide→Resin bound L-prolyl-L-ornithylglycinamide→N2-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-asparagine→Resin bound L-asparaginyl-S-(triphenylmethyl)-L-cysteinyl-L-prolyl-L-ornithylglycinamide→N-[[(9H-Fluoren-9-yl)methoxy]carbonyl]-L-threonine→Resin bound L-threonyl-L-asparaginyl-S-(triphenylmethyl)-L-cysteinyl-L-prolyl-L-ornithylglycinamide→N-(9-Fluorenylmethoxycarbonyl)-L-proline<-fgf->1-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-proline→N5-(tert-Butoxycarbonyl)-L-ornithine<-fgf->Nalpha-tert-Butoxycarbonyl-L-ornithine<-fgf->Nalpha-Boc-L-ornithine<-fgf->N2-Boc-L-ornithine<-fgf->(2S)-5-Amino-2-{[(tert-butoxy)carbonyl]amino}pentanoic acid→N-(9-Fluorenylmethoxycarbonyl)-S-trityl-L-cysteine<-fgf->N-[[(9H-Fluoren-9-yl)methoxy]carbonyl]-S-(triphenylmethyl)-L-cysteine
S-(Triphenylmethyl)-L-cysteine→N2-[[(9H-Fluoren-9-yl)methoxy]carbonyl]-L-asparaginyl-S-(triphenylmethyl)-L-cysteine→Resin bound L-prolyl-L-ornithylglycinamide→N2-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-asparagine→Resin bound L-asparaginyl-S-(triphenylmethyl)-L-cysteinyl-L-prolyl-L-ornithylglycinamide
Resin bound 9H-fluoren-9-ylmethyl (2-amino-2-oxoethyl)carbamate→Resin bound Gly-NH→N5-[1-(4,4-Dimethyl-2,6-dioxocyclohexylidene)ethyl]-N2-[[(9H-fluoren-9-yl)methoxy]carbonyl]-L-ornithine→Resin bound S-(triphenylmethyl)-L-cysteinyl-L-prolyl-N5-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]-L-ornithylglycinamide→Resin bound Orn(Dde)-Gly-NH→Resin bound L-prolyl-N5-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]-L-ornithylglycinamide→Resin bound Asn-Cys(Trt)-Pro-Orn(Dde)-Gly-NH→N-alpha-Fmoc-L-threonine<-fgf->N-(9H-Fluoren-9-ylmethoxycarbonyl)-L-threonine→Resin bound Thr-Asn-Cys(Trt)-Pro-Orn(Dde)-Gly→N2-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-asparagine→N-(9-Fluorenylmethoxycarbonyl)-L-proline→N-(9-Fluorenylmethoxycarbonyl)-S-trityl-L-cysteine→N-(9H-Fluoren-9-ylmethoxycarbonyl)glycine
S-(Triphenylmethyl)-L-cysteine→N2-[[(9H-Fluoren-9-yl)methoxy]carbonyl]-L-asparaginyl-S-(triphenylmethyl)-L-cysteine→Resin bound L-prolyl-N5-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]-L-ornithylglycinamide→N2-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-asparagine→Resin bound Asn-Cys(Trt)-Pro-Orn(Dde)-Gly-NH
本站可供应的对应中间体
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