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CAS 73-32-5
2(S)-Amino-3(S)-methylpentanoic acid(2S,3S)-2-Amino-3-methylpentanoic acid2(S)-Amino-3(S)-methylpentanoic acid<-fgf->(2S,3S)-2-Amino-3-methylpentanoic acid
登记编号：Atosiban-085
应用背景（按来源药适应症）
产科分娩（早产）阿托西班醋酸盐早产（孕37周前）阿托西班醋酸盐子宫内膜异位症阿托西班醋酸盐
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 阿托西班醋酸盐Atosiban acetate | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
2,5-Dioxopyrrolidin-1-yl O-ethyl-N-[3-[(triphenylmethyl)sulfanyl]propanoyl]-D-tyrosyl-L-isoleucyl-O-tert-butyl-L-threoninate→1-([3-[(Triphenylmethyl)sulfanyl]propanoyl]oxy)pyrrolidine-2,5-dione→O-Ethyl-D-tyrosine hydrogen chloride→O-Ethyl-N-[3-[(triphenylmethyl)sulfanyl]propanoyl]-D-tyrosine→2,5-Dioxopyrrolidin-1-yl O-ethyl-N-[3-[(triphenylmethyl)sulfanyl]propanoyl]-D-tyrosinate→2(S)-Amino-3(S)-methylpentanoic acid→O-Ethyl-N-[3-[(triphenylmethyl)sulfanyl]propanoyl]-D-tyrosyl-L-isoleucine→2,5-Dioxopyrrolidin-1-yl O-ethyl-N-[3-[(triphenylmethyl)sulfanyl]propanoyl]-D-tyrosyl-L-isoleucinate→O-tert-Butyl-L-threonine→O-Ethyl-N-[3-[(triphenylmethyl)sulfanyl]propanoyl]-D-tyrosyl-L-isoleucyl-O-tert-butyl-L-threonine→3-(Tritylsulfanyl)propanoic acid
O-Ethyl-N-[[(9H-fluoren-9-yl)methoxy]carbonyl]-D-tyrosyl-L-isoleucine→Resin bound L-threonyl-L-asparaginyl-S-(triphenylmethyl)-L-cysteinyl-L-prolyl-L-ornithylglycinamide→O-Ethyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-tyrosine→Resin bound O-ethyl-D-tyrosyl-L-isoleucyl-L-threonyl-L-asparaginyl-S-(triphenylmethyl)-L-cysteinyl-L-prolyl-L-ornithylglycinamide→(2S,3S)-2-Amino-3-methylpentanoic acid
O-Ethyl-N-[[(9H-fluoren-9-yl)methoxy]carbonyl]-D-tyrosyl-L-isoleucine→Resin bound Thr-Asn-Cys(Trt)-Pro-Orn(Dde)-Gly<-fgf->Resin bound L-threonyl-L-asparaginyl-S-(triphenylmethyl)-L-cysteinyl-L-prolyl-N5-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]-L-ornithylglycinamide→O-Ethyl-N-[(9H-fluoren-9-ylmethoxy)carbonyl]-D-tyrosine→Resin bound O-ethyl-D-tyrosyl-L-isoleucyl-L-threonyl-L-asparaginyl-S-(triphenylmethyl)-L-cysteinyl-L-prolyl-N5-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)ethyl]-L-ornithylglycinamide<-fgf->Resin bound D-Tyr(Et)-Ile-Thr-Asn-Cys(Trt)-Pro-Orn(Dde)-Gly→2(S)-Amino-3(S)-methylpentanoic acid<-fgf->(2S,3S)-2-Amino-3-methylpentanoic acid
本站可供应的对应中间体
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