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CAS 74936-72-4
(+/-)-5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic acid
登记编号：Lercanidipine Hydrochloride-007
应用背景（按来源药适应症）
原发性高血压缬沙坦/盐酸乐卡地平
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 缬沙坦/盐酸乐卡地平Valsartan/Lercanidipine Hydrochloride | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
4-Methylene-2-oxetanone→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl 3-oxobutanoate→(3-Nitrophenyl)methanone→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl (2Z)-2-[(3-nitrophenyl)methylidene]-3-oxobutanoate→3-Amino-2-butenoic acid methyl ester→(+/-)-5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic acid
1-Methoxybutane-1,3-dione→1-Chloro-2-methyl-2-propanol→1-Chloro-2-methylpropan-2-yl 3-oxobutanoate→(3-Nitrophenyl)methanone→1-Chloro-2-methylpropan-2-yl (2Z)-2-[(3-nitrophenyl)methylidene]-3-oxobutanoate→3-Amino-2-butenoic acid methyl ester→3-(1-Chloro-2-methylpropan-2-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate→3-(1-Bromo-2-methylpropan-2-yl) 5-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate→(+/-)-5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic acid→5-(Chlorocarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid methyl ester→1-Bromo-2-methylpropan-2-ol→(3,3-Diphenylpropyl)(methyl)amine
(3,3-Diphenylpropyl)(methyl)amine→1-Chloro-2-methyl-2-propanol→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol→(2-chloro-2-methylpropyl)(3,3-diphenylpropyl)methylamine→(+/-)-5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic acid
(+/-)-5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic acid→5-(Chlorocarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid methyl ester→2-Methyl-1-(methylamino)propan-2-ol p-toluenesulfonate→2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 1,1-dimethyl-2-(methylamino)ethyl methyl ester→3,3-Diphenylpropan-1-ol→4-Methylbenzenesulfonic acid 3,3-diphenylpropyl ester→1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid 2-[N-(3,3-diphenylpropyl)-N-methylamino]-1,1-dimethylethyl methyl diester oxalate
3-Phenyl-2(E)-propenoic acid→(2E)-3-phenylprop-2-enoyl chloride→Methylamine→N-Methyl-3-phenylacrylamide→Benzene→N-Methyl-3,3-diphenylpropanamide→(3,3-Diphenylpropyl)(methyl)amine→1-Chloro-2-methyl-2-propanol→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol→Methyl 5-[[(diethoxyphosphoryl)oxy]carbonyl]-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylate→(+/-)-5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic acid
4-Methylene-2-oxetanone→1-Cyano-2-hydroxyethane→2-Cyanoethyl 3-oxobutanoate→(3-Nitrophenyl)methanone→3-Amino-2-butenoic acid methyl ester→1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid 3-(2-cyanoethyl)5-methyl ester→(+/-)-5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic acid→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol
(3-Nitrophenyl)methanone→1-Methoxybutane-1,3-dione→(Z)-Methyl 3-aminobut-2-enoate→Dimethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate→(+/-)-5-(Methoxycarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydro-3-pyridinecarboxylic acid→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-ol→1-[(3,3-Diphenylpropyl)(methyl)amino]-2-methylpropan-2-yl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate→5-(Chlorocarbonyl)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid methyl ester→(3,3-Diphenylpropyl)(methyl)amine→1-Chloro-2-methyl-2-propanol
本站可供应的对应中间体
目录暂未收录该靶点的在售中间体 —— 可直接发起询价，需求会进入撮合池。
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。