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CAS 861841-90-9
1-(3-amino-5-(benzyloxy)-2-hydroxyphenyl)ethanone
登记编号：OLOD-005
应用背景（按来源药适应症）
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来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 盐酸奥达特罗Olodaterol Hydrochloride | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
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1-(2,5-dihydroxyphenyl)ethanone→(bromomethyl)benzene→1-(5-(benzyloxy)-2-hydroxyphenyl)ethanone→1-(5-(benzyloxy)-2-hydroxy-3-nitrophenyl)ethanone→1-(3-amino-5-(benzyloxy)-2-hydroxyphenyl)ethanone→2-chloroacetyl chloride→8-acetyl-6-(benzyloxy)-2H-benzo[b][1,4]oxazin-3(4H)-one→6-(benzyloxy)-8-(2-ethoxy-2-hydroxyacetyl)-2H-benzo[b][1,4]oxazin-3(4H)-one→1-(4-methoxyphenyl)-2-methylpropan-2-amine→6-(benzyloxy)-8-(1-hydroxy-2-((1-(4-methoxyphenyl)-2-methylpropan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one hydrochloride→6-hydroxy-8-(1-hydroxy-2-((1-(4-methoxyphenyl)-2-methylpropan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one hydrochloride
1-(5-(benzyloxy)-2-hydroxyphenyl)ethanone→1-(5-(benzyloxy)-2-hydroxy-3-nitrophenyl)ethanone→1-(3-amino-5-(benzyloxy)-2-hydroxyphenyl)ethanone→2-chloroacetyl chloride→8-acetyl-6-(benzyloxy)-2H-benzo[b][1,4]oxazin-3(4H)-one→1-(4-methoxyphenyl)-2-methylpropan-2-amine→6-(benzyloxy)-8-(2-chloroacetyl)-2H-benzo[b][1,4]oxazin-3(4H)-one→(R)-6-(benzyloxy)-8-(2-chloro-1-hydroxyethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one→(R)-6-(benzyloxy)-8-(oxiran-2-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one→(R)-6-(benzyloxy)-8-(1-hydroxy-2-((1-(4-methoxyphenyl)-2-methylpropan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
1-(2,5-dihydroxyphenyl)ethanone→(bromomethyl)benzene→1-(5-(benzyloxy)-2-hydroxyphenyl)ethanone→1-(5-(benzyloxy)-2-hydroxy-3-nitrophenyl)ethanone→1-(3-amino-5-(benzyloxy)-2-hydroxyphenyl)ethanone→2-chloroacetyl chloride→8-acetyl-6-(benzyloxy)-2H-benzo[b][1,4]oxazin-3(4H)-one→1-(4-methoxyphenyl)-2-methylpropan-2-amine→6-(benzyloxy)-8-(1-hydroxy-2-((1-(4-methoxyphenyl)-2-methylpropan-2-yl)amino)ethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one hydrochloride→(R)-6-(benzyloxy)-8-(oxiran-2-yl)-2H-benzo[b][1,4]oxazin-3(4H)-one→6-(benzyloxy)-8-(2-bromoacetyl)-2H-benzo[b][1,4]oxazin-3(4H)-one→(R)-6-(benzyloxy)-8-(2-bromo-1-hydroxyethyl)-2H-benzo[b][1,4]oxazin-3(4H)-one
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