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CAS 866088-09-7
N-(5-((E)-2-((2S,4R)-4-(benzyloxy)-6-methoxytetrahydro-2H-pyran-2-yl)vinyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide
登记编号：ROSU-021
应用背景（按来源药适应症）
高血压瑞舒伐他汀钙/非马沙坦钾三水合物血脂障碍瑞舒伐他汀钙/非马沙坦钾三水合物高血压瑞舒伐他汀钙/替米沙坦高脂血症瑞舒伐他汀钙/替米沙坦
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 瑞舒伐他汀钙/非马沙坦钾三水合物Fimasartan potassium trihydrate/Rosuvastatin calcium | Tier C · 观察 / 贸易 | - |
| 瑞舒伐他汀钙/替米沙坦Rosuvastatin Calcium/Telmisartan | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(4R,6S)-6-(chloromethyl)tetrahydro-2H-pyran-2,4-diol→(2S,4R)-2-(chloromethyl)-6-methoxytetrahydro-2H-pyran-4-ol→(2S,4R)-4-(benzyloxy)-2-(chloromethyl)-6-methoxytetrahydro-2H-pyran→((2S,4R)-4-(benzyloxy)-6-methoxytetrahydro-2H-pyran-2-yl)methyl acetate→((2S,4R)-4-(benzyloxy)-6-methoxytetrahydro-2H-pyran-2-yl)methanol→(2S,4R)-4-(benzyloxy)-6-methoxytetrahydro-2H-pyran-2-carbaldehyde→N-(5-((diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide→N-(5-((E)-2-((2S,4R)-4-(benzyloxy)-6-methoxytetrahydro-2H-pyran-2-yl)vinyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide→N-(4-(4-fluorophenyl)-5-((E)-2-((2S,4R)-4-hydroxy-6-methoxytetrahydro-2H-pyran-2-yl)vinyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide→N-(5-((E)-2-((2S,4R)-4,6-dihydroxytetrahydro-2H-pyran-2-yl)vinyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide→N-(4-(4-fluorophenyl)-5-((E)-2-((2S,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)vinyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide
(4R,6S)-6-(chloromethyl)tetrahydro-2H-pyran-2,4-diol→(2S,4R)-2-(chloromethyl)-6-methoxytetrahydro-2H-pyran-4-ol→(2S,4R)-4-(benzyloxy)-2-(chloromethyl)-6-methoxytetrahydro-2H-pyran→((2S,4R)-4-(benzyloxy)-6-methoxytetrahydro-2H-pyran-2-yl)methyl acetate→((2S,4R)-4-(benzyloxy)-6-methoxytetrahydro-2H-pyran-2-yl)methanol→(2S,4R)-4-(benzyloxy)-6-methoxytetrahydro-2H-pyran-2-carbaldehyde→N-(5-((diphenylphosphoryl)methyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide→N-(5-((E)-2-((2S,4R)-4-(benzyloxy)-6-methoxytetrahydro-2H-pyran-2-yl)vinyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide→N-(4-(4-fluorophenyl)-5-((E)-2-((2S,4R)-4-hydroxy-6-methoxytetrahydro-2H-pyran-2-yl)vinyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide→N-(5-((E)-2-((2S,4R)-4,6-dihydroxytetrahydro-2H-pyran-2-yl)vinyl)-4-(4-fluorophenyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide→N-(4-(4-fluorophenyl)-5-((E)-2-((2S,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)vinyl)-6-isopropylpyrimidin-2-yl)-N-methylmethanesulfonamide
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