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CAS 87269-85-0
(Methyl 2-(acetylamino)-3-(2-oxocyclopentyl)propanoate)
登记编号：Ramipril-003
应用背景（按来源药适应症）
高胆固醇血症阿托伐他汀钙/雷米普利高血压阿托伐他汀钙/雷米普利
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| 阿托伐他汀钙/雷米普利Atorvastatin Calcium Hydrate/Ramipril | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
1-(1-Cyclopentenyl)pyrrolidine→(+/-)-Methyl 2-(Acetylamino)-3-chloropropionate→(Methyl 2-(acetylamino)-3-(2-oxocyclopentyl)propanoate)→(2S,3aS,6aS)-Octahydrocyclopenta[b]pyrrole-2-carboxylic acid hydrochloride→Benzyl (2S,3aR,6aS)-octahydrocyclopenta[b]pyrrole-2-carboxylic acid hydrochloride→N-[(S)-(+)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanine→(2S,3aS,6aS)-1-[N-[1(S)-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanyl]perhydrocyclopenta[b]pyrrole-2-carboxylic acid→Benzyl (2S,3aS,6aS)-octahydrocyclopenta[b]pyrrole-2-carboxylate hydrochloride→Benzyl (2S,3aS,6aS)-octahydrocyclopenta[b]pyrrole-2-carboxylate sulfate
(Methyl 2-(acetylamino)-3-(2-oxocyclopentyl)propanoate)→Benzyl (2S,3aS,6aS)-octahydrocyclopenta[b]pyrrole-2-carboxylate hydrochloride→N-Acetyl-3-(2-oxocyclopentyl)-L-alanine→(2S)-2,3,3a,4,5,6-Hexahydrocyclopenta[b]pyrrole-2-carboxylic acid hydrochloride→(2S)-2,3,3a,4,5,6-Hexahydrocyclopenta[b]pyrrole-2-carboxylic acid 4-methylbenzenesulfonate→(2S,3aR,6aS)-octahydrocyclopenta[b]pyrrole-2-carboxylic acid hydrochloride→(2S,3aS,6aS)-Octahydrocyclopenta[b]pyrrole-2-carboxylic acid 4-methylbenzenesulfonate
Propyl L-serinate hydrochloride→N-Acetyl-3-chloro-L-alanine propyl ester→1-(1-Cyclopentenyl)pyrrolidine→N-Acetyl-3-(2-oxocyclopentyl)alanine propyl ester→N-Carbamoyl-3-(2-oxocyclopentyl)alanine→(Methyl 2-(acetylamino)-3-(2-oxocyclopentyl)propanoate)→3-(2-Oxocyclopentyl)-L-alanine→(2S,3aS,6aS)-Octahydrocyclopenta[b]pyrrole-2-carboxylic acid→Benzyl (2S,3aS,6aS)-octahydrocyclopenta[b]pyrrole-2-carboxylate 4-methylbenzenesulfonate→Ethyl (2S)-2-[[(2S)-1-chloro-1-oxopropan-2-yl]amino]-4-phenylbutanoate hydrochloride→N-[(S)-(+)-1-(Ethoxycarbonyl)-3-phenylpropyl]-L-alanine
(+/-)-2-Amino-3-hydroxypropionic acid→DL-Serine methyl ester hydrochloride→Ethyl serinate hydrogen chloride→2-Benzamido-3-ethoxy-3-oxopropyl benzoate→2-Benzamido-3-ethoxy-3-oxopropyl benzoate→Ethyl N,O-diacetylserinate→Ethyl 2-benzamidoprop-2-enoate→Ethyl 2-(benzoylamino)acrylate→2-Acetamido-2-propenoic acid methyl ester→1-Morpholinocyclopentene→Cyclopentanone→Ethyl N-benzoyl-3-(2-oxocyclopentyl)alaninate→Ethyl N-benzoyl-3-(2-oxocyclopentyl)alaninate→(Methyl 2-(acetylamino)-3-(2-oxocyclopentyl)propanoate)→Benzyl octahydrocyclopenta[b]pyrrole-2-carboxylate hydrogen chloride→Octahydrocyclopenta[b]pyrrole-2-carboxylic acid hydrogen chloride
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