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CAS 912807-27-3
((1S,2R,3R,4S)-4-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)cyclohexane-1,2-diyl)bis(methylene) bis(propane-1-sulfonate)
登记编号：SERL-009
应用背景（按来源药适应症）
大疱性表皮松解症Serlopitant
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| Serlopitant | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
2-(4-fluorophenyl)acetic acid→2-(4-fluorophenyl)-N-methoxy-N-methylacetamide→1-(4-fluorophenyl)but-3-en-2-one→(Z)-tert-butyl((1-(4-fluorophenyl)buta-1,3-dien-2-yl)oxy)dimethylsilane→diethyl fumarate→(1R,2S,3S)-diethyl 6-((tert-butyldimethylsilyl)oxy)-4'-fluoro-1,2,3,4-tetrahydro-[1,1'-biphenyl]-2,3-dicarboxylate→(1S,2S,3R)-diethyl 3-(4-fluorophenyl)-4-oxocyclohexane-1,2-dicarboxylate→(1S,2S,3R,4S)-diethyl 3-(4-fluorophenyl)-4-hydroxycyclohexane-1,2-dicarboxylate→((1S,2R,3R,4S)-4-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)cyclohexane-1,2-diyl)bis(methylene) bis(propane-1-sulfonate)→(1S,2S,3R,4S)-diethyl 4-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)cyclohexane-1,2-dicarboxylate→((1S,2R,3R,4S)-4-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)cyclohexane-1,2-diyl)dimethanol→((1S,2R,3R,4S)-4-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)cyclohexane-1,2-diyl)bis(methylene) dimethanesulfonate→(3aR,4R,5S,7aS)-2-benzyl-5-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-4-(4-fluorophenyl)octahydro-1H-isoindole→(3aR,4R,5S,7aS)-5-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-4-(4-fluorophenyl)octahydro-1H-isoindole→cyclopentane-1,3-dione
bis((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) fumarate→(1R,2S,3S)-bis((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 4'-fluoro-6-((triethylsilyl)oxy)-1,2,3,4-tetrahydro-[1,1'-biphenyl]-2,3-dicarboxylate→(1S,2S,3R)-bis((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 3-(4-fluorophenyl)-4-oxocyclohexane-1,2-dicarboxylate→(1S,2S,3R,4S)-bis((1R,2S,5R)-2-isopropyl-5-methylcyclohexyl) 3-(4-fluorophenyl)-4-hydroxycyclohexane-1,2-dicarboxylate→((1S,2R,3R,4S)-3-(4-fluorophenyl)-4-hydroxycyclohexane-1,2-diyl)dimethanol→((1S,2R,3R,4S)-3-(4-fluorophenyl)-4-hydroxycyclohexane-1,2-diyl)bis(methylene) bis(propane-1-sulfonate)→((1S,2R,3R,4S)-4-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)cyclohexane-1,2-diyl)bis(methylene) bis(propane-1-sulfonate)→(3aR,4R,5S,7aS)-2-allyl-5-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-4-(4-fluorophenyl)octahydro-1H-isoindole→(3aR,4R,5S,7aS)-5-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-4-(4-fluorophenyl)octahydro-1H-isoindole acetate→2-(4-fluorophenyl)acetic acid→2-(4-fluorophenyl)-N-methoxy-N-methylacetamide→1-(4-fluorophenyl)but-3-en-2-one→((1S,2R,3R,4S)-4-((R)-1-(3,5-bis(trifluoromethyl)phenyl)ethoxy)-3-(4-fluorophenyl)cyclohexane-1,2-diyl)bis(methylene) bis(propane-1-sulfonate)→(Z)-triethyl((1-(4-fluorophenyl)buta-1,3-dien-2-yl)oxy)silane
本站可供应的对应中间体
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