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CAS 949023-16-9
(4S,5R)-3-Benzoyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid
登记编号：(VII)101438-14-a、(IV)101438-52-a
应用背景（按来源药适应症）
乳腺癌Paclitaxel/Encequidar mesylate腺癌Paclitaxel/Encequidar mesylate血管肉瘤Paclitaxel/Encequidar mesylate实体瘤Paclitaxel/Encequidar mesylate
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| Paclitaxel/Encequidar mesylatePaclitaxel/Encequidar mesylate | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
(3aS)-8,8-Dimethylhexahydro-3a,6-methano-2lambda6-2lambda6,1-benzothiazole-2,2(3H)-dione→2-((4-methoxybenzyl)oxy)acetyl chloride→(1S,5S,7R)-4-{2-[(4-methoxyphenyl)methoxy]acetyl}-10,10-dimethyl-3-thia-4-azatricyclo[5.2.1.0(1,5)]decane-3,3-dione→N-[(1Z)-Phenylmethylidene]benzamide→(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-bis(acetyloxy)-2-(benzoyloxy)-1-hydroxy-10,14,17,17-tetramethyl-11-oxo-9-[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-15-yl (2R,4S,5R)-3-benzoyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylate→N-[(1S,2R)-3-[(1S,5S,7R)-10,10-dimethyl-3,3-dioxo-3-thia-4-azatricyclo[5.2.1.0(1,5)]decan-4-yl]-2-[(4-methoxyphenyl)methoxy]-3-oxo-1-phenylpropyl]benzamide→(1S,5S,7R)-4-{[(4S,5R)-3-benzoyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidin-5-yl]carbonyl}-10,10-dimethyl-3-thia-4-azatricyclo[5.2.1.0(1,5)]decane-3,3-dione→(4S,5R)-3-Benzoyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid→(1S,2S,3R,4S,7R,9S,10S,12R,15S)-4,12-Bis(acetyloxy)-1,15-dihydroxy-10,14,17,17-tetramethyl-11-oxo-9-[(triethylsilyl)oxy]-6-oxatetracyclo[11.3.1.0(3,10).0(4,7)]heptadec-13-en-2-yl benzoate
(2alpha,5beta,7beta,10beta,13alpha)-4-(Acetyloxy)-1,7,10,13-tetrahydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate→(2alpha,5beta,7beta,10beta,13alpha)-4,10-Bis(acetyloxy)-1,7,13-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate→(2alpha,5beta,7beta,10beta,13alpha)-4,10-Diacetoxy-1,13-dihydroxy-9-oxo-7-(2,2,2-trichloroacetoxy)-5,20-epoxytax-11-en-2-yl benzoate→(4S,5R)-3-Benzoyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylic acid→(2alpha,5beta,7beta,10beta,13alpha)-4,10-Diacetoxy-2-(benzoyloxy)-1-hydroxy-9-oxo-7-(2,2,2-trichloroacetoxy)-5,20-epoxytax-11-en-13-yl (4S,5R)-3-benzoyl-2-(4-methoxyphenyl)-4-phenyl-1,3-oxazolidine-5-carboxylate→(2alpha,5beta,7beta,10beta,13alpha)-4,10-Diacetoxy-13-[[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy]-1-hydroxy-9-oxo-7-(2,2,2-trichloroacetoxy)-5,20-epoxytax-11-en-2-yl benzoate
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