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CAS 95-25-0
5-chlorobenzo[d]oxazol-2(3H)-one
登记编号：AZD-7986-002
应用背景（按来源药适应症）
支气管扩张症Brensocatib肺疾病Brensocatib鼻窦炎Brensocatib囊性纤维化Brensocatib肝功能衰退Brensocatib肾功能不全Brensocatib
来源药（使用该中间体的合成路线）
| 品种 | 梯队 | 到期年 |
|---|---|---|
| Brensocatib | Tier C · 观察 / 贸易 | - |
合成路线中的位置（上下游链）
按路线登记顺序排列，左→右为合成方向；高亮为当前 CAS，其余可点击跳转对应档案。
AZD-7986→2-amino-4-chlorophenol→5-chlorobenzo[d]oxazol-2(3H)-one→5-chloro-3-methylbenzo[d]oxazol-2(3H)-one→3-methyl-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[d]oxazol-2(3H)-one→tert-butyl (S)-(1-amino-3-(4-iodophenyl)-1-oxopropan-2-yl)carbamate→tert-butyl (S)-(1-amino-3-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)-1-oxopropan-2-yl)carbamate→(S)-2-amino-3-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)propanamide→(S)-4-(tert-butoxycarbonyl)-1,4-oxazepane-2-carboxylic acid→tert-butyl (S)-2-(((S)-1-cyano-2-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)ethyl)carbamoyl)-1,4-oxazepane-4-carboxylate→(S)-methyl oxirane-2-carboxylate→methyl (S)-3-(dibenzylamino)-2-hydroxypropanoate→methyl propiolate→methyl (S,E)-3-((3-(dibenzylamino)-1-methoxy-1-oxopropan-2-yl)oxy)acrylate→methyl (S)-3-amino-2-(3-methoxy-3-oxopropoxy)propanoate→methyl (S)-5-oxo-1,4-oxazepane-2-carboxylate→4-(tert-butyl) 2-methyl (S)-5-oxo-1,4-oxazepane-2,4-dicarboxylate→4-(tert-butyl) 2-methyl (S)-1,4-oxazepane-2,4-dicarboxylate
AZD-7986→5-chlorobenzo[d]oxazol-2(3H)-one→5-chloro-3-methylbenzo[d]oxazol-2(3H)-one→tert-butyl (S)-(1-amino-3-(4-iodophenyl)-1-oxopropan-2-yl)carbamate→(S)-4-(tert-butoxycarbonyl)-1,4-oxazepane-2-carboxylic acid→tert-butyl (S)-2-(((S)-1-cyano-2-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)ethyl)carbamoyl)-1,4-oxazepane-4-carboxylate→methyl (chlorosulfonyl)carbamate→tert-butyl (S)-(1-cyano-2-(4-iodophenyl)ethyl)carbamate→5-(5,5-dimethyl-1,3,2-dioxaborinan-2-yl)-3-methylbenzo[d]oxazol-2(3H)-one→tert-butyl (S)-(1-cyano-2-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)ethyl)carbamate→(S)-2-amino-3-(4-(3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazol-5-yl)phenyl)propanenitrile→3-(benzylamino)propan-1-ol→(S)-2-((benzyloxy)methyl)oxirane→(S)-3-(benzyl(3-(benzyloxy)-2-hydroxypropyl)amino)propan-1-ol→(S)-4-benzyl-2-((benzyloxy)methyl)-1,4-oxazepane→tert-butyl (S)-2-(hydroxymethyl)-1,4-oxazepane-4-carboxylate→5,5,5',5'-tetramethyl-2,2'-bi(1,3,2-dioxaborinane)
本站可供应的对应中间体
同 CAS 多家在售供应横向对比；价格区间为供应方挂牌口径，实价以询价确认为准。
| 供应商 | 产品 | 价格区间 | 最小起订 | 货期 | 资质 | 操作 |
|---|---|---|---|---|---|---|
| Unibest Nantong cGMP Site | 3-Methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-3H-benzooxazol-2-one Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | (S)-4-(tert-butoxycarbonyl)-1,4-oxazepane-2-carboxylicacid Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Qualified Partner — East China API Works | tert-butyl (S)-(1-cyano-2-(4-iodophenyl)ethyl)carbamate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Nantong cGMP Site | 5-(5,5-Dimethyl-1,3,2-dioxaborinan-2-yl)-3-methyl-1,3-benzoxazol-2(3H)-one Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — | |
| Unibest Taizhou GMP-like Site | tert-butyl (S)-(1-amino-3-(4-iodophenyl)-1-oxopropan-2-yl)carbamate Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
本页为中间体 CAS 注册档案：同 CAS 的多条路线登记已合并；后续供应商报价与买方需求以该 CAS 为主键撮合。