苹果酸卡博替尼

Tier B — Position early

Cabozantinib S-malate · all drugs expiring in 2029 →

Exelixis Inc

Originator

2012

First approval

2029

Expiry (public)

$1.03B ▲

Peak sales

化学药

Type

Targets：VEGFR1、VEGFR2、VEGFR3、KIT、Trk-B、TYRO3、ROS、AXL、RET、TIE2、c-Met、FLT3、MerTK

Brand：Cometriq、Cabometyx

Indications (approved)：神经内分泌瘤、胰腺神经内分泌肿瘤、肾细胞癌、肝细胞癌、甲状腺瘤、神经内分泌癌

Regional status

批准上市

2012-11-29

批准上市

2014-03-21

China

申请上市

2020-09-28

Japan

批准上市

2020-03-25

Synthetic routes & intermediates3 routes

Originator routes × 1Optimised (non-patent) × 1Process routes × 1

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 7 · Total yield 3.2 g

Code	CAS No.	Intermediate
CABO-001	1131-62-0 Available	1-(3,4-dimethoxyphenyl)ethan-1-one
CABO-002	4101-32-0 Available	1-(4,5-dimethoxy-2-nitrophenyl)ethanone
CABO-003	4101-30-8 Available	1-(2-amino-4,5-dimethoxyphenyl)ethanone
CABO-004	109-94-4 Available	ethyl formate
CABO-005	13425-93-9 Available	6,7-dimethoxyquinolin-4-ol
CABO-006	849217-54-5 Available	6,7-dimethoxyquinolin-4-yl trifluoromethanesulfonate
CABO-007	849217-60-3 Available	N-(4-fluorophenyl)-N-(4-hydroxyphenyl)cyclopropane-1,1-dicarboxamide
CABO-008	598-10-7 Available	cyclopropane-1,1-dicarboxylic acid
CABO-009	371-40-4 Available	4-fluoroaniline
CABO-010	849217-48-7 Available	methyl 1-((4-fluorophenyl)carbamoyl)cyclopropanecarboxylate
CABO-011	123-30-8 Available	4-aminophenol

OptimisedRoute 3Steps 5 · Total yield 1.2 g

Synthetic routes & intermediates Route 3

Code	CAS No.	Intermediate
CABO-009	371-40-4 Available	4-fluoroaniline
CABO-011	123-30-8 Available	4-aminophenol
CABO-012	35654-56-9 Available	4-chloro-6,7-dimethoxyquinoline
CABO-017	1559-02-0 Available	diethyl cyclopropane-1,1-dicarboxylate
CABO-018	3697-66-3 Available	1-(ethoxycarbonyl)cyclopropane-1-carboxylic acid
CABO-019	1584696-72-9 Available	ethyl 1-((4-hydroxyphenyl)carbamoyl)cyclopropane-1-carboxylate
CABO-020	1584696-80-9 Available	ethyl 1-((4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)carbamoyl)cyclopropane-1-carboxylate
CABO-021	849217-77-2 Available	1-((4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)carbamoyl)cyclopropane-1-carboxylic acid

ProcessRoute 2Steps 5 · Total yield 5.0 kg

Synthetic routes & intermediates Route 2

Code	CAS No.	Intermediate
CABO-004	109-94-4 Available	ethyl formate
CABO-005	13425-93-9 Available	6,7-dimethoxyquinolin-4-ol
CABO-012	35654-56-9 Available	4-chloro-6,7-dimethoxyquinoline
CABO-013	100-02-7 Available	4-nitrophenol
CABO-014	190728-24-6 Available	6,7-dimethoxy-4-(4-nitrophenoxy)quinoline
CABO-015	190728-25-7 Available	4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline
CABO-016	1219937-98-0 Available	1-((4-fluorophenyl)carbamoyl)cyclopropanecarboxylic acid

Frequently asked questions

What are the approved indications of Cabozantinib S-malate?

Approved indications include: 神经内分泌瘤, 胰腺神经内分泌肿瘤, 肾细胞癌, 肝细胞癌, 甲状腺瘤, 神经内分泌癌.

When does the Cabozantinib S-malate patent expire?

Based on public sources, the Cabozantinib S-malate patent expires in 2029.

How many synthesis routes are recorded for Cabozantinib S-malate?

3 synthesis routes are recorded; the shortest is 5 steps with 5.0 kg total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Cabozantinib S-malate intermediates?

21 intermediate CAS of Cabozantinib S-malate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Cabozantinib S-malate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24