CAS 123-30-8

4-aminophenol

Codes：CABO-011、SORF-004

Application context (from source-drug indications)

神经内分泌瘤苹果酸卡博替尼胰腺神经内分泌肿瘤苹果酸卡博替尼肾细胞癌苹果酸卡博替尼肝细胞癌苹果酸卡博替尼甲状腺瘤苹果酸卡博替尼神经内分泌癌苹果酸卡博替尼甲状腺瘤甲苯磺酸索拉非尼肝细胞癌甲苯磺酸索拉非尼肾细胞癌甲苯磺酸索拉非尼侵袭性纤维瘤病甲苯磺酸索拉非尼肝癌甲苯磺酸索拉非尼骨髓增生性疾病甲苯磺酸索拉非尼

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
苹果酸卡博替尼Cabozantinib S-malate	Tier B — Position early	2029
甲苯磺酸索拉非尼Sorafenib Tosylate	Tier B — Position early	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

苹果酸卡博替尼原研路线steps: 7total yield: 3.2 g

1-(3,4-dimethoxyphenyl)ethan-1-one→1-(4,5-dimethoxy-2-nitrophenyl)ethanone→1-(2-amino-4,5-dimethoxyphenyl)ethanone→ethyl formate→6,7-dimethoxyquinolin-4-ol→6,7-dimethoxyquinolin-4-yl trifluoromethanesulfonate→N-(4-fluorophenyl)-N-(4-hydroxyphenyl)cyclopropane-1,1-dicarboxamide→cyclopropane-1,1-dicarboxylic acid→4-fluoroaniline→methyl 1-((4-fluorophenyl)carbamoyl)cyclopropanecarboxylate→4-aminophenol

苹果酸卡博替尼优化路线steps: 5total yield: 1.2 g

4-fluoroaniline→4-aminophenol→4-chloro-6,7-dimethoxyquinoline→diethyl cyclopropane-1,1-dicarboxylate→1-(ethoxycarbonyl)cyclopropane-1-carboxylic acid→ethyl 1-((4-hydroxyphenyl)carbamoyl)cyclopropane-1-carboxylate→ethyl 1-((4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)carbamoyl)cyclopropane-1-carboxylate→1-((4-((6,7-dimethoxyquinolin-4-yl)oxy)phenyl)carbamoyl)cyclopropane-1-carboxylic acid

甲苯磺酸索拉非尼原研路线steps: 5total yield: 118.19 g

picolinic acid→4-chloropicolinoyl chloride hydrochloride→4-chloropicolinoyl chloride→4-aminophenol→4-(4-aminophenoxy)-N-methylpicolinamide→1-chloro-4-isocyanato-2-(trifluoromethyl)benzene→4-chloro-3-(trifluoromethyl)aniline

甲苯磺酸索拉非尼优化路线steps: 3total yield: 32 g

4-chloropicolinoyl chloride→4-aminophenol→4-chloro-3-(trifluoromethyl)aniline→1-(4-hydroxyphenyl)urea→1-(4-chloro-3-(trifluoromethyl)phenyl)-3-(4-hydroxyphenyl)urea

甲苯磺酸索拉非尼优化路线steps: 3total yield: 3.96 g

picolinic acid→4-chloropicolinoyl chloride→4-aminophenol→4-(4-aminophenoxy)-N-methylpicolinamide→phenyl (4-chloro-3-(trifluoromethyl)phenyl)carbamate

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications
Unibest Nantong cGMP Site	4-Hydroxy-6,7-dimethoxyqunioline Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	4-((6,7-Dimethoxyquinolin -4-yl)oxy)aniline Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid Pharmaceutical Intermediates	询价	询价	询价	—

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