CAS 109-94-4

ethyl formate

Codes：CABO-004

Application context (from source-drug indications)

神经内分泌瘤苹果酸卡博替尼胰腺神经内分泌肿瘤苹果酸卡博替尼肾细胞癌苹果酸卡博替尼肝细胞癌苹果酸卡博替尼甲状腺瘤苹果酸卡博替尼神经内分泌癌苹果酸卡博替尼

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
苹果酸卡博替尼Cabozantinib S-malate	Tier B — Position early	2029

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

苹果酸卡博替尼原研路线steps: 7total yield: 3.2 g

1-(3,4-dimethoxyphenyl)ethan-1-one→1-(4,5-dimethoxy-2-nitrophenyl)ethanone→1-(2-amino-4,5-dimethoxyphenyl)ethanone→ethyl formate→6,7-dimethoxyquinolin-4-ol→6,7-dimethoxyquinolin-4-yl trifluoromethanesulfonate→N-(4-fluorophenyl)-N-(4-hydroxyphenyl)cyclopropane-1,1-dicarboxamide→cyclopropane-1,1-dicarboxylic acid→4-fluoroaniline→methyl 1-((4-fluorophenyl)carbamoyl)cyclopropanecarboxylate→4-aminophenol

苹果酸卡博替尼工艺路线steps: 5total yield: 5.0 kg

ethyl formate→6,7-dimethoxyquinolin-4-ol→4-chloro-6,7-dimethoxyquinoline→4-nitrophenol→6,7-dimethoxy-4-(4-nitrophenoxy)quinoline→4-((6,7-dimethoxyquinolin-4-yl)oxy)aniline→1-((4-fluorophenyl)carbamoyl)cyclopropanecarboxylic acid

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications
Unibest Nantong cGMP Site	4-Hydroxy-6,7-dimethoxyqunioline Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	4-((6,7-Dimethoxyquinolin -4-yl)oxy)aniline Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	1-(4-Fluorophenylcarbamoyl)cyclopropanecarboxylic acid Pharmaceutical Intermediates	询价	询价	询价	—

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