马来酸阿伐曲泊帕
Tier C — Watch / tradeAvatrombopag Maleate · all drugs expiring in 2030 →
Targets：TpoR
Brand：Doptelet、DOPTELET、苏可欣
Indications (approved)：血小板减少、特发性血小板减少性紫癜、肝脏疾病
Regional status
Synthetic routes & intermediates1 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| AVAT-001 | 34730-20-6Available | 1-(4-chlorothiophen-2-yl)ethanone |
| AVAT-002 | 677007-73-7Available | 2-bromo-1-(4-chlorothiophen-2-yl)ethanone |
| AVAT-003 | 62-56-6Available | thiourea |
| AVAT-004 | 570407-10-2Available | 4-(4-chlorothiophen-2-yl)thiazol-2-amine |
| AVAT-005 | 17766-28-8Available | 1-cyclohexylpiperazine |
| AVAT-006 | 570407-42-0Available | 4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine |
| AVAT-007 | 41667-95-2Available | 5,6-dichloronicotinic acid |
| AVAT-008 | 570403-04-2Available | 5,6-dichloro-N-(4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)nicotinamide |
| AVAT-009 | 1126-09-6Available | ethyl piperidine-4-carboxylate |
| AVAT-010 | 570403-14-4Available | ethyl 1-(3-chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylate |
| AVAT-011 | 110-16-7Available | maleic acid |
Frequently asked questions
What are the approved indications of Avatrombopag Maleate?
Approved indications include: 血小板减少, 特发性血小板减少性紫癜, 肝脏疾病.
When does the Avatrombopag Maleate patent expire?
Based on public sources, the Avatrombopag Maleate patent expires in 2030.
How many synthesis routes are recorded for Avatrombopag Maleate?
1 synthesis routes are recorded; the shortest is 7 steps with 20 kg total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Avatrombopag Maleate intermediates?
11 intermediate CAS of Avatrombopag Maleate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.
How do I get a quote for Avatrombopag Maleate intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24