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CAS 677007-73-7
2-bromo-1-(4-chlorothiophen-2-yl)ethanone
Codes：AVAT-002
Application context (from source-drug indications)
血小板减少马来酸阿伐曲泊帕特发性血小板减少性紫癜马来酸阿伐曲泊帕肝脏疾病马来酸阿伐曲泊帕
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 马来酸阿伐曲泊帕Avatrombopag Maleate | Tier C — Watch / trade | 2030 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
1-(4-chlorothiophen-2-yl)ethanone→2-bromo-1-(4-chlorothiophen-2-yl)ethanone→thiourea→4-(4-chlorothiophen-2-yl)thiazol-2-amine→1-cyclohexylpiperazine→4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine→5,6-dichloronicotinic acid→5,6-dichloro-N-(4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)nicotinamide→ethyl piperidine-4-carboxylate→ethyl 1-(3-chloro-5-((4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-yl)carbamoyl)pyridin-2-yl)piperidine-4-carboxylate→maleic acid
Intermediates available on this site
Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.
| Supplier | Product | Price band | MOQ | Lead time | Qualifications |
|---|---|---|---|---|---|
| Qualified Partner — East China API Works | 4-(4-chloro-2-thienyl)-2-ThiazolaMine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Nantong cGMP Site | 4-(4-chlorothiophen-2-yl)-5-(4-cyclohexylpiperazin-1-yl)thiazol-2-amine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Unibest Taizhou GMP-like Site | 1-Cyclohexylpiperazine Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
| Qualified Partner — East China API Works | 5,6-Dichloronicotinic acid Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.