阿贝西利

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Abemaciclib · all drugs expiring in 2029 →

礼来制药

Originator

2017

First approval

2029

Expiry (public)

$5.72B ▲

Peak sales

化学药

Type

Targets：CDK6、CDK4

Brand：唯择、Verzenios、Verzenio

Indications (approved)：乳腺癌

Regional status

批准上市

2017-09-28

批准上市

2018-09-26

China

批准上市

2020-12-30

Japan

批准上市

2018-09-21

Synthetic routes & intermediates2 routes

Originator routes × 1Optimised (non-patent) × 1Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 9 · Total yield 20.4 g

Code	CAS No.	Intermediate
ABEM-001	75-31-0 Available	propan-2-amine
ABEM-002	1118-69-0 Available	N-isopropylacetamide
ABEM-003	67567-26-4 Available	4-bromo-2,6-difluoroaniline
ABEM-004	1231930-29-2 Available	(E)-N'-(4-bromo-2,6-difluorophenyl)-N-isopropylacetimidamide
ABEM-005	1231930-33-8 Available	6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
ABEM-006	73183-34-3 Available	4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)
ABEM-007	1231930-37-2 Available	4-fluoro-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole
ABEM-008	2927-71-1 Available	2,4-dichloro-5-fluoropyrimidine
ABEM-009	1231930-42-9 Available	6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
ABEM-010	1180132-17-5 Available	5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-amine
ABEM-011	5308-25-8 Available	1-ethylpiperazine
ABEM-012	149806-06-4 Available	6-bromonicotinaldehyde
ABEM-013	1231930-25-8 Available	1-((6-bromopyridin-3-yl)methyl)-4-ethylpiperazine

OptimisedRoute 2Steps 3 · Total yield /

Synthetic routes & intermediates Route 2

Code	CAS No.	Intermediate
ABEM-007	1231930-37-2 Available	4-fluoro-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole
ABEM-008	2927-71-1 Available	2,4-dichloro-5-fluoropyrimidine
ABEM-009	1231930-42-9 Available	6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
ABEM-011	5308-25-8 Available	1-ethylpiperazine
ABEM-014	69879-22-7 Available	6-aminonicotinaldehyde
ABEM-015	1627082-92-1 Available	6-((5-fluoro-4-(4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazol-6-yl)pyrimidin-2-yl)amino)nicotinaldehyde

Frequently asked questions

What are the approved indications of Abemaciclib?

Approved indications include: 乳腺癌.

When does the Abemaciclib patent expire?

Based on public sources, the Abemaciclib patent expires in 2029.

How many synthesis routes are recorded for Abemaciclib?

2 synthesis routes are recorded; the shortest is 3 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Abemaciclib intermediates?

15 intermediate CAS of Abemaciclib are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Abemaciclib intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24