CAS 1118-69-0

N-isopropylacetamide

Codes：ABEM-002

Application context (from source-drug indications)

乳腺癌阿贝西利

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
阿贝西利Abemaciclib	Tier A — Act now	2029

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

阿贝西利原研路线steps: 9total yield: 20.4 g

propan-2-amine→N-isopropylacetamide→4-bromo-2,6-difluoroaniline→(E)-N'-(4-bromo-2,6-difluorophenyl)-N-isopropylacetimidamide→6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→4-fluoro-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole→2,4-dichloro-5-fluoropyrimidine→6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole→5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-amine→1-ethylpiperazine→6-bromonicotinaldehyde→1-((6-bromopyridin-3-yl)methyl)-4-ethylpiperazine

Intermediates available on this site

Side-by-side comparison of all listed offers on this CAS; price bands are list-price ranges, final price subject to RFQ confirmation.

Supplier	Product	Price band	MOQ	Lead time	Qualifications
Unibest Nantong cGMP Site	5-((4-Ethylpiperazin-1-yl)methyl)pyridin-2-amine Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Taizhou GMP-like Site	1H-BenziMidazole, 6-(2-chloro-5-fluoro-4-pyriMidinyl)-4-fluoro-2-Methyl-1-(1-Methylethyl)- Pharmaceutical Intermediates	询价	询价	询价	—
Qualified Partner — East China API Works	6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole Pharmaceutical Intermediates	询价	询价	询价	—
Unibest Nantong cGMP Site	2,4-Dichloro-5-fluoropyrimidine Pharmaceutical Intermediates	询价	询价	询价	—

This is a CAS-level registry record: registrations across routes are merged. Supplier offers and buyer demands will be matched on this CAS as the primary key.