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CAS 1231930-33-8
6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole
Codes：ABEM-005
Application context (from source-drug indications)
乳腺癌阿贝西利
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 阿贝西利Abemaciclib | Tier A — Act now | 2029 |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
propan-2-amine→N-isopropylacetamide→4-bromo-2,6-difluoroaniline→(E)-N'-(4-bromo-2,6-difluorophenyl)-N-isopropylacetimidamide→6-bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole→4,4,4',4',5,5,5',5'-octamethyl-2,2'-bi(1,3,2-dioxaborolane)→4-fluoro-1-isopropyl-2-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-benzo[d]imidazole→2,4-dichloro-5-fluoropyrimidine→6-(2-chloro-5-fluoropyrimidin-4-yl)-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole→5-((4-ethylpiperazin-1-yl)methyl)pyridin-2-amine→1-ethylpiperazine→6-bromonicotinaldehyde→1-((6-bromopyridin-3-yl)methyl)-4-ethylpiperazine
Intermediates available on this site
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| Supplier | Product | Price band | MOQ | Lead time | Qualifications |
|---|---|---|---|---|---|
| Qualified Partner — East China API Works | 6-Bromo-4-fluoro-1-isopropyl-2-methyl-1H-benzo[d]imidazole Pharmaceutical Intermediates | 询价 | 询价 | 询价 | — |
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