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Pimavanserin Tartrate · all drugs expiring in 2029 →

阿卡迪亚制药公司
Originator
2016
First approval
2029
Expiry (public)
$0.55B ▲
Peak sales
化学药
Type

Targets5-HT2A

BrandNuplazid

Indications (approved)妄想、幻觉

Regional status

US
批准上市
2016-04-29
EU
临床三期
2007-06-01
China
临床三期
2024-09-27
Japan
-

Synthetic routes & intermediates2 routes

Originator routes × 1Optimised (non-patent) × 1Process routes × 0

Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.

OriginatorRoute 1Steps 6 · Total yield 8.3 kg
Synthetic routes & intermediates Route 1
CodeCAS No.Intermediate
PIMAV-001123-08-0Available4-hydroxybenzaldehyde
PIMAV-00278-77-3Available1-bromo-2-methylpropane
PIMAV-00318962-07-7Available4-isobutoxybenzaldehyde
PIMAV-004882035-15-6(E)-4-isobutoxybenzaldehyde oxime
PIMAV-0054734-09-2(4-isobutoxyphenyl)methanamine
PIMAV-006639863-75-51-isobutoxy-4-(isocyanatomethyl)benzene
PIMAV-007359878-47-0N-(4-fluorobenzyl)-1-methylpiperidin-4-amine
PIMAV-0081445-73-41-methylpiperidin-4-one
PIMAV-009140-75-0(4-fluorophenyl)methanamine
PIMAV-01056553-60-7sodium triacetoxyhydroborate
OptimisedRoute 2Steps 4 · Total yield /
Synthetic routes & intermediates Route 2
CodeCAS No.Intermediate
PIMAV-00278-77-3Available1-bromo-2-methylpropane
PIMAV-0054734-09-2(4-isobutoxyphenyl)methanamine
PIMAV-006639863-75-51-isobutoxy-4-(isocyanatomethyl)benzene
PIMAV-011767-00-04-hydroxybenzonitrile
PIMAV-012177948-43-5tert-butyl 4-((4-fluorobenzyl)amino)piperidine-1-carboxylate
PIMAV-01387120-72-7tert-butyl 4-aminopiperidine-1-carboxylate
PIMAV-014459-57-44-fluorobenzaldehyde

Frequently asked questions

What are the approved indications of Pimavanserin Tartrate?

Approved indications include: 妄想, 幻觉.

When does the Pimavanserin Tartrate patent expire?

Based on public sources, the Pimavanserin Tartrate patent expires in 2029.

How many synthesis routes are recorded for Pimavanserin Tartrate?

2 synthesis routes are recorded; the shortest is 4 steps with / total yield. Intermediates in each route carry codes and CAS numbers.

Where can I buy Pimavanserin Tartrate intermediates?

3 intermediate CAS of Pimavanserin Tartrate are available through the Unibest supply network — see the route tables on this page and request a quote per CAS.

How do I get a quote for Pimavanserin Tartrate intermediates?

Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.

Source: cross-verified data (structured fields only) · 2026-09-24