CAS 639863-75-5

1-isobutoxy-4-(isocyanatomethyl)benzene

Codes：PIMAV-006

Application context (from source-drug indications)

妄想酒石酸匹莫范色林幻觉酒石酸匹莫范色林

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
酒石酸匹莫范色林Pimavanserin Tartrate	Tier C — Watch / trade	2029

Position in synthesis routes (up/downstream chain)

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酒石酸匹莫范色林原研路线steps: 6total yield: 8.3 kg

4-hydroxybenzaldehyde→1-bromo-2-methylpropane→4-isobutoxybenzaldehyde→(E)-4-isobutoxybenzaldehyde oxime→(4-isobutoxyphenyl)methanamine→1-isobutoxy-4-(isocyanatomethyl)benzene→N-(4-fluorobenzyl)-1-methylpiperidin-4-amine→1-methylpiperidin-4-one→(4-fluorophenyl)methanamine→sodium triacetoxyhydroborate

酒石酸匹莫范色林优化路线steps: 4total yield: /

1-bromo-2-methylpropane→(4-isobutoxyphenyl)methanamine→1-isobutoxy-4-(isocyanatomethyl)benzene→4-hydroxybenzonitrile→tert-butyl 4-((4-fluorobenzyl)amino)piperidine-1-carboxylate→tert-butyl 4-aminopiperidine-1-carboxylate→4-fluorobenzaldehyde

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