CAS 459-57-4

4-fluorobenzaldehyde

Codes：PIMAV-014、LOBE-006

Application context (from source-drug indications)

妄想酒石酸匹莫范色林幻觉酒石酸匹莫范色林二型糖尿病洛贝格列酮硫酸盐胃肌轻瘫洛贝格列酮硫酸盐肾功能不全洛贝格列酮硫酸盐肝功能异常洛贝格列酮硫酸盐

Source drugs (routes using this intermediate)

Drug	Tier	Expiry
酒石酸匹莫范色林Pimavanserin Tartrate	Tier C — Watch / trade	2029
洛贝格列酮硫酸盐Lobeglitazone Sulfate	Tier C — Watch / trade	-

Position in synthesis routes (up/downstream chain)

Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.

酒石酸匹莫范色林优化路线steps: 4total yield: /

1-bromo-2-methylpropane→(4-isobutoxyphenyl)methanamine→1-isobutoxy-4-(isocyanatomethyl)benzene→4-hydroxybenzonitrile→tert-butyl 4-((4-fluorobenzyl)amino)piperidine-1-carboxylate→tert-butyl 4-aminopiperidine-1-carboxylate→4-fluorobenzaldehyde

洛贝格列酮硫酸盐原研路线steps: 6total yield: 2.03 g

4,6-dichloropyrimidine→4-methoxyphenol→4-chloro-6-(4-methoxyphenoxy)pyrimidine→2-(methylamino)ethan-1-ol→2-((6-(4-methoxyphenoxy)pyrimidin-4-yl)(methyl)amino)ethanol→4-fluorobenzaldehyde→4-(2-((6-(4-methoxyphenoxy)pyrimidin-4-yl)(methyl)amino)ethoxy)benzaldehyde→thiazolidine-2,4-dione→(Z)-5-(4-(2-((6-(4-methoxyphenoxy)pyrimidin-4-yl)(methyl)amino)ethoxy)benzylidene)thiazolidine-2,4-dione

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