吡昔替尼
Tier C — Watch / tradePexidartinib
Targets：KIT、CSF1R、FLT3
Brand：Turalio
Indications (approved)：腱鞘巨细胞瘤
Regional status
Synthetic routes & intermediates1 routes
Routes are ordered originator first, then optimised / process (non-patent) routes; each lists steps, overall yield and the intermediate table (code / CAS / name) — ready for supplier sourcing and RFQ. Rendered by this site from structured data; no third-party route graphics used.
| Code | CAS No. | Intermediate |
|---|---|---|
| PEXI-001 | 866546-07-8 | 5-chloro-1H-pyrrolo[2,3-b]pyridine |
| PEXI-002 | 954112-61-9 | 5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde |
| PEXI-003 | 1029052-72-9 | 5-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde |
| PEXI-004 | 1072-97-5 | 5-bromopyridin-2-amine |
| PEXI-005 | 1029052-73-0 | (6-aminopyridin-3-yl)(5-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)methanol |
| PEXI-006 | 1029052-74-1 | 5-((5-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)pyridin-2-amine |
| PEXI-007 | 386704-12-7 | 6-(trifluoromethyl)nicotinaldehyde |
| PEXI-008 | - | 5-((5-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine |
Frequently asked questions
What are the approved indications of Pexidartinib?
Approved indications include: 腱鞘巨细胞瘤.
When does the Pexidartinib patent expire?
No public expiry year is available for Pexidartinib yet; this page updates once verified.
How many synthesis routes are recorded for Pexidartinib?
1 synthesis routes are recorded; the shortest is 6 steps with 13.50 mg total yield. Intermediates in each route carry codes and CAS numbers.
Where can I buy Pexidartinib intermediates?
All intermediates in Pexidartinib routes have CAS profiles — you can submit an RFQ per CAS and it enters the Unibest matching pool.
How do I get a quote for Pexidartinib intermediates?
Open the CAS profile of the target intermediate from this page, or submit an RFQ directly — the CAS enters the matching flow automatically and the supply network responds with quotes.
Source: cross-verified data (structured fields only) · 2026-09-24