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CAS 1029052-73-0
(6-aminopyridin-3-yl)(5-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)methanol
Codes：PEXI-005
Application context (from source-drug indications)
腱鞘巨细胞瘤吡昔替尼丛状神经纤维瘤吡昔替尼急性淋巴细胞白血病吡昔替尼急性早幼粒细胞白血病吡昔替尼肉瘤吡昔替尼黑色素瘤吡昔替尼
Source drugs (routes using this intermediate)
| Drug | Tier | Expiry |
|---|---|---|
| 吡昔替尼Pexidartinib | Tier C — Watch / trade | - |
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
5-chloro-1H-pyrrolo[2,3-b]pyridine→5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde→5-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde→5-bromopyridin-2-amine→(6-aminopyridin-3-yl)(5-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)methanol→5-((5-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)pyridin-2-amine→6-(trifluoromethyl)nicotinaldehyde→5-((5-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine
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