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CAS 1072-97-5
5-bromopyridin-2-amine
Codes：PERAM-001、PEXI-004、VEMF-010
Application context (from source-drug indications)
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Source drugs (routes using this intermediate)
Position in synthesis routes (up/downstream chain)
Ordered by route registration; left → right is the synthesis direction. The highlighted node is the current CAS; others link to their own profiles.
5-bromopyridin-2-amine→5-bromo-3-iodopyridin-2-amine→5-bromo-3-iodopyridin-2(1H)-one→phenylboronic acid→5-bromo-3-iodo-1-phenylpyridin-2(1H)-one→2-(1,3,2-dioxaborinan-2-yl)benzonitrile→2-(5-bromo-2-oxo-1-phenyl-1,2-dihydropyridin-3-yl)benzonitrile→2-(2-oxo-1-phenyl-5-(tributylstannyl)-1,2-dihydropyridin-3-yl)benzonitrile→2-chloropyridine
5-chloro-1H-pyrrolo[2,3-b]pyridine→5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde→5-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridine-3-carbaldehyde→5-bromopyridin-2-amine→(6-aminopyridin-3-yl)(5-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)methanol→5-((5-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)pyridin-2-amine→6-(trifluoromethyl)nicotinaldehyde→5-((5-chloro-1-(phenylsulfonyl)-1H-pyrrolo[2,3-b]pyridin-3-yl)methyl)-N-((6-(trifluoromethyl)pyridin-3-yl)methyl)pyridin-2-amine
2,6-difluoro-3-(propylsulfonamido)benzoic acid→(4-chlorophenyl)boronic acid→5-bromopyridin-2-amine→5-(4-chlorophenyl)pyridin-2-amine→5-(4-chlorophenyl)-3-iodopyridin-2-amine→(E)-2-(2-ethoxyvinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane→5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine→3-bromo-5-(4-chlorophenyl)pyridin-2-amine→ethynyltrimethylsilane→5-(4-chlorophenyl)-3-((trimethylsilyl)ethynyl)pyridin-2-amine
2,6-difluoro-3-(propylsulfonamido)benzoic acid→5-bromo-1H-pyrrolo[2,3-b]pyridine→N-(3-(5-bromo-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide→(4-chlorophenyl)boronic acid→5-bromopyridin-2-amine→(E)-2-(2-ethoxyvinyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane→5-bromo-3-iodopyridin-2-amine→2,6-dichlorobenzoyl chloride→N-(3-(5-bromo-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide→N-(3-(5-(4-chlorophenyl)-1-(2,6-dichlorobenzoyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
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